Prevalence of migraine in adults with celiac disease: A case control cross-sectional study.

<h4>Aim</h4>Celiac disease (CD) is an immune-mediated disorder with various manifestations. The aim of this study was to evaluate the prevalence of gastrointestinal (GI) and extra-intestinal symptoms of celiac patients, especially migraine, and compare it with healthy individuals.<h4&...

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Autores principales:	Mohammad M Fanaeian, Nazanin Alibeik, Azita Ganji, Hafez Fakheri, Golnaz Ekhlasi, Bijan Shahbazkhani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9752be87a3d84184a937728fdb842c7c
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spelling	oai:doaj.org-article:9752be87a3d84184a937728fdb842c7c2021-12-02T20:12:57ZPrevalence of migraine in adults with celiac disease: A case control cross-sectional study.1932-620310.1371/journal.pone.0259502https://doaj.org/article/9752be87a3d84184a937728fdb842c7c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259502https://doaj.org/toc/1932-6203<h4>Aim</h4>Celiac disease (CD) is an immune-mediated disorder with various manifestations. The aim of this study was to evaluate the prevalence of gastrointestinal (GI) and extra-intestinal symptoms of celiac patients, especially migraine, and compare it with healthy individuals.<h4>Methods</h4>We compared 1000 celiac subjects (CS) registered at our celiac center with the control group for headache-based on International Classification of Headache Disorders, third edition criteria and their GI symptoms. Besides, CS with migraine and non-migrainous headache were compared in terms of GI symptoms and accompanied conditions.<h4>Results</h4>Headache was more common in CS than controls (34% vs 27% respectively, P value<0.001) and more prevalent in females (71.9% in females vs 28% in males, P value = 0.004). Moreover, the prevalence of migraine in CS was higher than controls (20.7 vs 11.9% respectively, P value<0.001). Furthermore, migraine was more prevalent in females with CD (80% in females vs 19% in males, P value = 0.033), and often without aura (76%). Abdominal pain (76.9%, P value = 0.025), diarrhea (54.9%, P value = 0.002), and constipation (42.9%, P value = 0.011) were the most common GI symptoms in CS with headache and more prevalent in CS with migraine. Conversely, type 1 diabetes mellitus was less common in CS with migraine than in CS with non-migrainous headache. (P value = 0.001). On multivariate logistic regression analysis, female sex (OR 1.50, 95%CI 1.22-1.83, P value < 0.001), and CD (OR 1.36, 95%CI 1.12-1.65, P value = 0.002) were independent predictors of headache, whereas age more than 60 years (OR 0.70, 95%CI 0.50-0.97, P value = 0.032) had a protective effect.<h4>Conclusion</h4>Headache especially migraine is more prevalent in CS than healthy controls. In addition, abdominal pain, diarrhea, and constipation are more common in CS with migraine than in CS with non-migrainous headaches. Therefore, evaluation of CD in patients with migraine and these simultaneous GI symptoms seems reasonable.Mohammad M FanaeianNazanin AlibeikAzita GanjiHafez FakheriGolnaz EkhlasiBijan ShahbazkhaniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259502 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad M Fanaeian Nazanin Alibeik Azita Ganji Hafez Fakheri Golnaz Ekhlasi Bijan Shahbazkhani Prevalence of migraine in adults with celiac disease: A case control cross-sectional study.
description	<h4>Aim</h4>Celiac disease (CD) is an immune-mediated disorder with various manifestations. The aim of this study was to evaluate the prevalence of gastrointestinal (GI) and extra-intestinal symptoms of celiac patients, especially migraine, and compare it with healthy individuals.<h4>Methods</h4>We compared 1000 celiac subjects (CS) registered at our celiac center with the control group for headache-based on International Classification of Headache Disorders, third edition criteria and their GI symptoms. Besides, CS with migraine and non-migrainous headache were compared in terms of GI symptoms and accompanied conditions.<h4>Results</h4>Headache was more common in CS than controls (34% vs 27% respectively, P value<0.001) and more prevalent in females (71.9% in females vs 28% in males, P value = 0.004). Moreover, the prevalence of migraine in CS was higher than controls (20.7 vs 11.9% respectively, P value<0.001). Furthermore, migraine was more prevalent in females with CD (80% in females vs 19% in males, P value = 0.033), and often without aura (76%). Abdominal pain (76.9%, P value = 0.025), diarrhea (54.9%, P value = 0.002), and constipation (42.9%, P value = 0.011) were the most common GI symptoms in CS with headache and more prevalent in CS with migraine. Conversely, type 1 diabetes mellitus was less common in CS with migraine than in CS with non-migrainous headache. (P value = 0.001). On multivariate logistic regression analysis, female sex (OR 1.50, 95%CI 1.22-1.83, P value < 0.001), and CD (OR 1.36, 95%CI 1.12-1.65, P value = 0.002) were independent predictors of headache, whereas age more than 60 years (OR 0.70, 95%CI 0.50-0.97, P value = 0.032) had a protective effect.<h4>Conclusion</h4>Headache especially migraine is more prevalent in CS than healthy controls. In addition, abdominal pain, diarrhea, and constipation are more common in CS with migraine than in CS with non-migrainous headaches. Therefore, evaluation of CD in patients with migraine and these simultaneous GI symptoms seems reasonable.
format	article
author	Mohammad M Fanaeian Nazanin Alibeik Azita Ganji Hafez Fakheri Golnaz Ekhlasi Bijan Shahbazkhani
author_facet	Mohammad M Fanaeian Nazanin Alibeik Azita Ganji Hafez Fakheri Golnaz Ekhlasi Bijan Shahbazkhani
author_sort	Mohammad M Fanaeian
title	Prevalence of migraine in adults with celiac disease: A case control cross-sectional study.
title_short	Prevalence of migraine in adults with celiac disease: A case control cross-sectional study.
title_full	Prevalence of migraine in adults with celiac disease: A case control cross-sectional study.
title_fullStr	Prevalence of migraine in adults with celiac disease: A case control cross-sectional study.
title_full_unstemmed	Prevalence of migraine in adults with celiac disease: A case control cross-sectional study.
title_sort	prevalence of migraine in adults with celiac disease: a case control cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9752be87a3d84184a937728fdb842c7c
work_keys_str_mv	AT mohammadmfanaeian prevalenceofmigraineinadultswithceliacdiseaseacasecontrolcrosssectionalstudy AT nazaninalibeik prevalenceofmigraineinadultswithceliacdiseaseacasecontrolcrosssectionalstudy AT azitaganji prevalenceofmigraineinadultswithceliacdiseaseacasecontrolcrosssectionalstudy AT hafezfakheri prevalenceofmigraineinadultswithceliacdiseaseacasecontrolcrosssectionalstudy AT golnazekhlasi prevalenceofmigraineinadultswithceliacdiseaseacasecontrolcrosssectionalstudy AT bijanshahbazkhani prevalenceofmigraineinadultswithceliacdiseaseacasecontrolcrosssectionalstudy
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Prevalence of migraine in adults with celiac disease: A case control cross-sectional study.

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