Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma

Tissue context can dictate why a gene can have seemingly opposing functions in different settings. ELF3 is tumor suppressive in many cancers of epithelial origin but in lung cancer, the authors describe an oncogenic role in the adenocarcinoma histology of non-small cell lung cancer.

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Autores principales:	Katey S. S. Enfield, Erin A. Marshall, Christine Anderson, Kevin W. Ng, Sara Rahmati, Zhaolin Xu, Megan Fuller, Katy Milne, Daniel Lu, Rocky Shi, David A. Rowbotham, Daiana D. Becker-Santos, Fraser D. Johnson, John C. English, Calum E. MacAulay, Stephen Lam, William W. Lockwood, Raj Chari, Aly Karsan, Igor Jurisica, Wan L. Lam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97564470fd144a769823f07282f004b8
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spelling	oai:doaj.org-article:97564470fd144a769823f07282f004b82021-12-02T15:35:53ZEpithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma10.1038/s41467-019-13295-y2041-1723https://doaj.org/article/97564470fd144a769823f07282f004b82019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13295-yhttps://doaj.org/toc/2041-1723Tissue context can dictate why a gene can have seemingly opposing functions in different settings. ELF3 is tumor suppressive in many cancers of epithelial origin but in lung cancer, the authors describe an oncogenic role in the adenocarcinoma histology of non-small cell lung cancer.Katey S. S. EnfieldErin A. MarshallChristine AndersonKevin W. NgSara RahmatiZhaolin XuMegan FullerKaty MilneDaniel LuRocky ShiDavid A. RowbothamDaiana D. Becker-SantosFraser D. JohnsonJohn C. EnglishCalum E. MacAulayStephen LamWilliam W. LockwoodRaj ChariAly KarsanIgor JurisicaWan L. LamNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katey S. S. Enfield Erin A. Marshall Christine Anderson Kevin W. Ng Sara Rahmati Zhaolin Xu Megan Fuller Katy Milne Daniel Lu Rocky Shi David A. Rowbotham Daiana D. Becker-Santos Fraser D. Johnson John C. English Calum E. MacAulay Stephen Lam William W. Lockwood Raj Chari Aly Karsan Igor Jurisica Wan L. Lam Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma
description	Tissue context can dictate why a gene can have seemingly opposing functions in different settings. ELF3 is tumor suppressive in many cancers of epithelial origin but in lung cancer, the authors describe an oncogenic role in the adenocarcinoma histology of non-small cell lung cancer.
format	article
author	Katey S. S. Enfield Erin A. Marshall Christine Anderson Kevin W. Ng Sara Rahmati Zhaolin Xu Megan Fuller Katy Milne Daniel Lu Rocky Shi David A. Rowbotham Daiana D. Becker-Santos Fraser D. Johnson John C. English Calum E. MacAulay Stephen Lam William W. Lockwood Raj Chari Aly Karsan Igor Jurisica Wan L. Lam
author_facet	Katey S. S. Enfield Erin A. Marshall Christine Anderson Kevin W. Ng Sara Rahmati Zhaolin Xu Megan Fuller Katy Milne Daniel Lu Rocky Shi David A. Rowbotham Daiana D. Becker-Santos Fraser D. Johnson John C. English Calum E. MacAulay Stephen Lam William W. Lockwood Raj Chari Aly Karsan Igor Jurisica Wan L. Lam
author_sort	Katey S. S. Enfield
title	Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma
title_short	Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma
title_full	Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma
title_fullStr	Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma
title_full_unstemmed	Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma
title_sort	epithelial tumor suppressor elf3 is a lineage-specific amplified oncogene in lung adenocarcinoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/97564470fd144a769823f07282f004b8
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Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma

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