Comparison of familial and sporadic multiple sclerosis in Iraqi patients

Background: Multiple sclerosis (MS) is one of the increasing prevalent neurologic disorders. Epidemiologic and family studies implicate genetic and environmental factors in determining susceptibility to MS. The exact effect of the former is intended for investigation in our study. Objectives: The o...

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Autores principales:	Hasan A. Al-hamadani, Hazim A. Marah, Farah Al-Saffar
Formato:	article
Lenguaje:	EN
Publicado:	Faculty of Medicine University of Baghdad 2021
Materias:	Multiple sclerosis and familial Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9757fba4a06c49b8812c84b3afc0c4da
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spelling	oai:doaj.org-article:9757fba4a06c49b8812c84b3afc0c4da2021-11-25T14:09:23ZComparison of familial and sporadic multiple sclerosis in Iraqi patients0041-94192410-8057https://doaj.org/article/9757fba4a06c49b8812c84b3afc0c4da2021-11-01T00:00:00Zhttps://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/760https://doaj.org/toc/0041-9419https://doaj.org/toc/2410-8057 Background: Multiple sclerosis (MS) is one of the increasing prevalent neurologic disorders. Epidemiologic and family studies implicate genetic and environmental factors in determining susceptibility to MS. The exact effect of the former is intended for investigation in our study. Objectives: The objective of the study is to compare the demographic features, clinical presenting features, and clinical course between familial and sporadic cases of MS. Materials and Methods: this is a retrospective cohort study conducted in Multiple Sclerosis Center in the Medical City in Baghdad. The records of the MS center in Baghdad Teaching Hospital were surveyed, and data from 13 patients with positive family history of MS, and 13 patients with out family history of MS was analyzed. Results: Regarding the clinical presentation, for those with family history of MS the common presenting symptoms were sensory symptoms and transverse myelitis, and those without family history of MS was pyramidal, for those with family history of MS 11 patients had initial course of relapsing remitting MS ( 84.6%) ,of them 4 patients progressed into secondary progressive MS (36.4%); 2 patients had primary progressive MS as initial course, for those with negative family history of MS 12 patients had initial course of relapsing remitting MS, of them 5 patients progressed into Secondary progressive MS (41.6%); 1 patients had primary progressive MS as initial course (7.7 %.). No significant difference was found in the investigated parameters, except for the inverse relation between age of onset and lag time to diagnosis. Conclusion: Familial MS do not significantly differ from sporadic MS in terms of the demographic patterns and clinical course and presentation. This is not the case for the relationship between the age of disease onset and lag time to diagnosis. Hasan A. Al-hamadaniHazim A. MarahFarah Al-SaffarFaculty of Medicine University of BaghdadarticleMultiple sclerosis and familialMedicineRMedicine (General)R5-920ENمجلة كلية الطب, Vol 54, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multiple sclerosis and familial Medicine R Medicine (General) R5-920
spellingShingle	Multiple sclerosis and familial Medicine R Medicine (General) R5-920 Hasan A. Al-hamadani Hazim A. Marah Farah Al-Saffar Comparison of familial and sporadic multiple sclerosis in Iraqi patients
description	Background: Multiple sclerosis (MS) is one of the increasing prevalent neurologic disorders. Epidemiologic and family studies implicate genetic and environmental factors in determining susceptibility to MS. The exact effect of the former is intended for investigation in our study. Objectives: The objective of the study is to compare the demographic features, clinical presenting features, and clinical course between familial and sporadic cases of MS. Materials and Methods: this is a retrospective cohort study conducted in Multiple Sclerosis Center in the Medical City in Baghdad. The records of the MS center in Baghdad Teaching Hospital were surveyed, and data from 13 patients with positive family history of MS, and 13 patients with out family history of MS was analyzed. Results: Regarding the clinical presentation, for those with family history of MS the common presenting symptoms were sensory symptoms and transverse myelitis, and those without family history of MS was pyramidal, for those with family history of MS 11 patients had initial course of relapsing remitting MS ( 84.6%) ,of them 4 patients progressed into secondary progressive MS (36.4%); 2 patients had primary progressive MS as initial course, for those with negative family history of MS 12 patients had initial course of relapsing remitting MS, of them 5 patients progressed into Secondary progressive MS (41.6%); 1 patients had primary progressive MS as initial course (7.7 %.). No significant difference was found in the investigated parameters, except for the inverse relation between age of onset and lag time to diagnosis. Conclusion: Familial MS do not significantly differ from sporadic MS in terms of the demographic patterns and clinical course and presentation. This is not the case for the relationship between the age of disease onset and lag time to diagnosis.
format	article
author	Hasan A. Al-hamadani Hazim A. Marah Farah Al-Saffar
author_facet	Hasan A. Al-hamadani Hazim A. Marah Farah Al-Saffar
author_sort	Hasan A. Al-hamadani
title	Comparison of familial and sporadic multiple sclerosis in Iraqi patients
title_short	Comparison of familial and sporadic multiple sclerosis in Iraqi patients
title_full	Comparison of familial and sporadic multiple sclerosis in Iraqi patients
title_fullStr	Comparison of familial and sporadic multiple sclerosis in Iraqi patients
title_full_unstemmed	Comparison of familial and sporadic multiple sclerosis in Iraqi patients
title_sort	comparison of familial and sporadic multiple sclerosis in iraqi patients
publisher	Faculty of Medicine University of Baghdad
publishDate	2021
url	https://doaj.org/article/9757fba4a06c49b8812c84b3afc0c4da
work_keys_str_mv	AT hasanaalhamadani comparisonoffamilialandsporadicmultiplesclerosisiniraqipatients AT hazimamarah comparisonoffamilialandsporadicmultiplesclerosisiniraqipatients AT farahalsaffar comparisonoffamilialandsporadicmultiplesclerosisiniraqipatients
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Comparison of familial and sporadic multiple sclerosis in Iraqi patients

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