A single donor is sufficient to produce a highly functional in vitro antibody library

Here, the authors construct and validate an in vitro antibody library from a single, healthy donor. They demonstrate the functionality of the library using several therapeutically relevant targets and were able to obtain many different antibodies with the desired biophysical properties.

Guardado en:

Detalles Bibliográficos
Autores principales:	M. Frank Erasmus, Sara D’Angelo, Fortunato Ferrara, Leslie Naranjo, André A. Teixeira, Rebecca Buonpane, Shaun M. Stewart, Horacio G. Nastri, Andrew R. M. Bradbury
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/97589959248d40069c6d04e7cbd5a7d0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:97589959248d40069c6d04e7cbd5a7d0
record_format	dspace
spelling	oai:doaj.org-article:97589959248d40069c6d04e7cbd5a7d02021-12-02T13:17:41ZA single donor is sufficient to produce a highly functional in vitro antibody library10.1038/s42003-021-01881-02399-3642https://doaj.org/article/97589959248d40069c6d04e7cbd5a7d02021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01881-0https://doaj.org/toc/2399-3642Here, the authors construct and validate an in vitro antibody library from a single, healthy donor. They demonstrate the functionality of the library using several therapeutically relevant targets and were able to obtain many different antibodies with the desired biophysical properties.M. Frank ErasmusSara D’AngeloFortunato FerraraLeslie NaranjoAndré A. TeixeiraRebecca BuonpaneShaun M. StewartHoracio G. NastriAndrew R. M. BradburyNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 M. Frank Erasmus Sara D’Angelo Fortunato Ferrara Leslie Naranjo André A. Teixeira Rebecca Buonpane Shaun M. Stewart Horacio G. Nastri Andrew R. M. Bradbury A single donor is sufficient to produce a highly functional in vitro antibody library
description	Here, the authors construct and validate an in vitro antibody library from a single, healthy donor. They demonstrate the functionality of the library using several therapeutically relevant targets and were able to obtain many different antibodies with the desired biophysical properties.
format	article
author	M. Frank Erasmus Sara D’Angelo Fortunato Ferrara Leslie Naranjo André A. Teixeira Rebecca Buonpane Shaun M. Stewart Horacio G. Nastri Andrew R. M. Bradbury
author_facet	M. Frank Erasmus Sara D’Angelo Fortunato Ferrara Leslie Naranjo André A. Teixeira Rebecca Buonpane Shaun M. Stewart Horacio G. Nastri Andrew R. M. Bradbury
author_sort	M. Frank Erasmus
title	A single donor is sufficient to produce a highly functional in vitro antibody library
title_short	A single donor is sufficient to produce a highly functional in vitro antibody library
title_full	A single donor is sufficient to produce a highly functional in vitro antibody library
title_fullStr	A single donor is sufficient to produce a highly functional in vitro antibody library
title_full_unstemmed	A single donor is sufficient to produce a highly functional in vitro antibody library
title_sort	single donor is sufficient to produce a highly functional in vitro antibody library
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97589959248d40069c6d04e7cbd5a7d0
work_keys_str_mv	AT mfrankerasmus asingledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT saradangelo asingledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT fortunatoferrara asingledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT leslienaranjo asingledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT andreateixeira asingledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT rebeccabuonpane asingledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT shaunmstewart asingledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT horaciognastri asingledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT andrewrmbradbury asingledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT mfrankerasmus singledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT saradangelo singledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT fortunatoferrara singledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT leslienaranjo singledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT andreateixeira singledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT rebeccabuonpane singledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT shaunmstewart singledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT horaciognastri singledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary AT andrewrmbradbury singledonorissufficienttoproduceahighlyfunctionalinvitroantibodylibrary
_version_	1718393345764491264

A single donor is sufficient to produce a highly functional in vitro antibody library

Ejemplares similares