An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

Neuroblastoma (NB) is often driven by MYCN amplification. Here, the authors show that the most frequent genetic lesion, gain of 17q21-ter in NB leads to overexpression of ALYREF, which forms a complex with MYCN, regulating MYCN stability via the deubiquitinating enzyme, USP3.

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Autores principales:	Zsuzsanna Nagy, Janith A. Seneviratne, Maxwell Kanikevich, William Chang, Chelsea Mayoh, Pooja Venkat, Yanhua Du, Cizhong Jiang, Alice Salib, Jessica Koach, Daniel R. Carter, Rituparna Mittra, Tao Liu, Michael W. Parker, Belamy B. Cheung, Glenn M. Marshall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9758c1cb40dc42078fa4de67f4245a4d
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spelling	oai:doaj.org-article:9758c1cb40dc42078fa4de67f4245a4d2021-12-02T13:24:12ZAn ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability10.1038/s41467-021-22143-x2041-1723https://doaj.org/article/9758c1cb40dc42078fa4de67f4245a4d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22143-xhttps://doaj.org/toc/2041-1723Neuroblastoma (NB) is often driven by MYCN amplification. Here, the authors show that the most frequent genetic lesion, gain of 17q21-ter in NB leads to overexpression of ALYREF, which forms a complex with MYCN, regulating MYCN stability via the deubiquitinating enzyme, USP3.Zsuzsanna NagyJanith A. SeneviratneMaxwell KanikevichWilliam ChangChelsea MayohPooja VenkatYanhua DuCizhong JiangAlice SalibJessica KoachDaniel R. CarterRituparna MittraTao LiuMichael W. ParkerBelamy B. CheungGlenn M. MarshallNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zsuzsanna Nagy Janith A. Seneviratne Maxwell Kanikevich William Chang Chelsea Mayoh Pooja Venkat Yanhua Du Cizhong Jiang Alice Salib Jessica Koach Daniel R. Carter Rituparna Mittra Tao Liu Michael W. Parker Belamy B. Cheung Glenn M. Marshall An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability
description	Neuroblastoma (NB) is often driven by MYCN amplification. Here, the authors show that the most frequent genetic lesion, gain of 17q21-ter in NB leads to overexpression of ALYREF, which forms a complex with MYCN, regulating MYCN stability via the deubiquitinating enzyme, USP3.
format	article
author	Zsuzsanna Nagy Janith A. Seneviratne Maxwell Kanikevich William Chang Chelsea Mayoh Pooja Venkat Yanhua Du Cizhong Jiang Alice Salib Jessica Koach Daniel R. Carter Rituparna Mittra Tao Liu Michael W. Parker Belamy B. Cheung Glenn M. Marshall
author_facet	Zsuzsanna Nagy Janith A. Seneviratne Maxwell Kanikevich William Chang Chelsea Mayoh Pooja Venkat Yanhua Du Cizhong Jiang Alice Salib Jessica Koach Daniel R. Carter Rituparna Mittra Tao Liu Michael W. Parker Belamy B. Cheung Glenn M. Marshall
author_sort	Zsuzsanna Nagy
title	An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability
title_short	An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability
title_full	An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability
title_fullStr	An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability
title_full_unstemmed	An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability
title_sort	alyref-mycn coactivator complex drives neuroblastoma tumorigenesis through effects on usp3 and mycn stability
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9758c1cb40dc42078fa4de67f4245a4d
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An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

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