TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Diabetes mellitus remains one of the most pressing problems in the 21st century. The research objective was to study the level of glycotoxins and oxidation-reduction potential of a serum/cell at the complicated and uncomplicated course of diabetes mellitus type 2 was and find the ways to correct the...

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Autores principales:	N. A. Shemyakina, E. V. Namokonov, M. A. Darenskaya
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	glyoxal methylglyoxal malondialdehyde diabetes complications of diabetes cysteine glutathione antioxidant system Science Q
Acceso en línea:	https://doaj.org/article/975c2325529a48d7b18ada06a3f5f2e0
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spelling	oai:doaj.org-article:975c2325529a48d7b18ada06a3f5f2e02021-11-23T06:14:39ZTO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS2541-94202587-959610.12737/article_5a0a8ee3048e76.65175111https://doaj.org/article/975c2325529a48d7b18ada06a3f5f2e02017-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/491https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Diabetes mellitus remains one of the most pressing problems in the 21st century. The research objective was to study the level of glycotoxins and oxidation-reduction potential of a serum/cell at the complicated and uncomplicated course of diabetes mellitus type 2 was and find the ways to correct the disorder. Materials and methods. There were three groups of patients aged from 55 up to 70 years, a total of 80 people. The main group (group No. 3) was presented by 40 men suffering from a diabetes mellitus type 2 with a macrovascular disease of the lower extremities. Depending on the chosen remedy and the carried-out therapy, patients of the first group were sectioned into subgroups on 20 people, in the 2nd subgroup additionally N-acetylcysteine solution was introduced in a daily dose of 600 mg once, intravenously, within 7 days. Definition of the studied indicators was made by HPLS methods, prior to therapy, for the third and seventh day. Results. Obtained data confirm activation of polyol pathway of glucose disintegration. Antioxidant potential of the serum and cells decreases. Using N-acetylcysteini in complex therapy reduces implications of carbonyl and oxidative stresses, due to multiple decrease of the final products of glycation. Conclusions. When identifying the presented indicators in patients with diabetic macroangiopathy of the lower extremities, the administration of N-acetylcysteine, intravenously in a daily dose of 600 mg (7 days course) is recommended.N. A. ShemyakinaE. V. NamokonovM. A. DarenskayaScientific Сentre for Family Health and Human Reproduction Problemsarticleglyoxalmethylglyoxalmalondialdehydediabetescomplications of diabetescysteineglutathioneantioxidant systemScienceQRUActa Biomedica Scientifica, Vol 2, Iss 6, Pp 167-171 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	glyoxal methylglyoxal malondialdehyde diabetes complications of diabetes cysteine glutathione antioxidant system Science Q
spellingShingle	glyoxal methylglyoxal malondialdehyde diabetes complications of diabetes cysteine glutathione antioxidant system Science Q N. A. Shemyakina E. V. Namokonov M. A. Darenskaya TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
description	Diabetes mellitus remains one of the most pressing problems in the 21st century. The research objective was to study the level of glycotoxins and oxidation-reduction potential of a serum/cell at the complicated and uncomplicated course of diabetes mellitus type 2 was and find the ways to correct the disorder. Materials and methods. There were three groups of patients aged from 55 up to 70 years, a total of 80 people. The main group (group No. 3) was presented by 40 men suffering from a diabetes mellitus type 2 with a macrovascular disease of the lower extremities. Depending on the chosen remedy and the carried-out therapy, patients of the first group were sectioned into subgroups on 20 people, in the 2nd subgroup additionally N-acetylcysteine solution was introduced in a daily dose of 600 mg once, intravenously, within 7 days. Definition of the studied indicators was made by HPLS methods, prior to therapy, for the third and seventh day. Results. Obtained data confirm activation of polyol pathway of glucose disintegration. Antioxidant potential of the serum and cells decreases. Using N-acetylcysteini in complex therapy reduces implications of carbonyl and oxidative stresses, due to multiple decrease of the final products of glycation. Conclusions. When identifying the presented indicators in patients with diabetic macroangiopathy of the lower extremities, the administration of N-acetylcysteine, intravenously in a daily dose of 600 mg (7 days course) is recommended.
format	article
author	N. A. Shemyakina E. V. Namokonov M. A. Darenskaya
author_facet	N. A. Shemyakina E. V. Namokonov M. A. Darenskaya
author_sort	N. A. Shemyakina
title	TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
title_short	TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
title_full	TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
title_fullStr	TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
title_full_unstemmed	TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
title_sort	to the question of diagnostics and ways of correction of the diabetic macrovascular disease of the lower extremities in patients with type 2 diabetes mellitus
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/975c2325529a48d7b18ada06a3f5f2e0
work_keys_str_mv	AT nashemyakina tothequestionofdiagnosticsandwaysofcorrectionofthediabeticmacrovasculardiseaseofthelowerextremitiesinpatientswithtype2diabetesmellitus AT evnamokonov tothequestionofdiagnosticsandwaysofcorrectionofthediabeticmacrovasculardiseaseofthelowerextremitiesinpatientswithtype2diabetesmellitus AT madarenskaya tothequestionofdiagnosticsandwaysofcorrectionofthediabeticmacrovasculardiseaseofthelowerextremitiesinpatientswithtype2diabetesmellitus
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TO THE QUESTION OF DIAGNOSTICS AND WAYS OF CORRECTION OF THE DIABETIC MACROVASCULAR DISEASE OF THE LOWER EXTREMITIES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

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