LSD1 protects against hippocampal and cortical neurodegeneration

“LSD1 is a histone demethylase that plays many roles during development. Here, the authors provide evidence that loss of LSD1 in adult mice leads to paralysis and neurodegeneration in the hippocampus and cortex and suggest a potential link between LSD1 and human neurodegenerative disease.

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Autores principales:	Michael A. Christopher, Dexter A. Myrick, Benjamin G. Barwick, Amanda K. Engstrom, Kirsten A. Porter-Stransky, Jeremy M. Boss, David Weinshenker, Allan I. Levey, David J. Katz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/975c9ba119ac4b22972a6cb8a6b32326
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spelling	oai:doaj.org-article:975c9ba119ac4b22972a6cb8a6b323262021-12-02T17:06:01ZLSD1 protects against hippocampal and cortical neurodegeneration10.1038/s41467-017-00922-92041-1723https://doaj.org/article/975c9ba119ac4b22972a6cb8a6b323262017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00922-9https://doaj.org/toc/2041-1723“LSD1 is a histone demethylase that plays many roles during development. Here, the authors provide evidence that loss of LSD1 in adult mice leads to paralysis and neurodegeneration in the hippocampus and cortex and suggest a potential link between LSD1 and human neurodegenerative disease.Michael A. ChristopherDexter A. MyrickBenjamin G. BarwickAmanda K. EngstromKirsten A. Porter-StranskyJeremy M. BossDavid WeinshenkerAllan I. LeveyDavid J. KatzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael A. Christopher Dexter A. Myrick Benjamin G. Barwick Amanda K. Engstrom Kirsten A. Porter-Stransky Jeremy M. Boss David Weinshenker Allan I. Levey David J. Katz LSD1 protects against hippocampal and cortical neurodegeneration
description	“LSD1 is a histone demethylase that plays many roles during development. Here, the authors provide evidence that loss of LSD1 in adult mice leads to paralysis and neurodegeneration in the hippocampus and cortex and suggest a potential link between LSD1 and human neurodegenerative disease.
format	article
author	Michael A. Christopher Dexter A. Myrick Benjamin G. Barwick Amanda K. Engstrom Kirsten A. Porter-Stransky Jeremy M. Boss David Weinshenker Allan I. Levey David J. Katz
author_facet	Michael A. Christopher Dexter A. Myrick Benjamin G. Barwick Amanda K. Engstrom Kirsten A. Porter-Stransky Jeremy M. Boss David Weinshenker Allan I. Levey David J. Katz
author_sort	Michael A. Christopher
title	LSD1 protects against hippocampal and cortical neurodegeneration
title_short	LSD1 protects against hippocampal and cortical neurodegeneration
title_full	LSD1 protects against hippocampal and cortical neurodegeneration
title_fullStr	LSD1 protects against hippocampal and cortical neurodegeneration
title_full_unstemmed	LSD1 protects against hippocampal and cortical neurodegeneration
title_sort	lsd1 protects against hippocampal and cortical neurodegeneration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/975c9ba119ac4b22972a6cb8a6b32326
work_keys_str_mv	AT michaelachristopher lsd1protectsagainsthippocampalandcorticalneurodegeneration AT dexteramyrick lsd1protectsagainsthippocampalandcorticalneurodegeneration AT benjamingbarwick lsd1protectsagainsthippocampalandcorticalneurodegeneration AT amandakengstrom lsd1protectsagainsthippocampalandcorticalneurodegeneration AT kirstenaporterstransky lsd1protectsagainsthippocampalandcorticalneurodegeneration AT jeremymboss lsd1protectsagainsthippocampalandcorticalneurodegeneration AT davidweinshenker lsd1protectsagainsthippocampalandcorticalneurodegeneration AT allanilevey lsd1protectsagainsthippocampalandcorticalneurodegeneration AT davidjkatz lsd1protectsagainsthippocampalandcorticalneurodegeneration
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LSD1 protects against hippocampal and cortical neurodegeneration

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