Acute Psychosis Due to Anti-N-Methyl D-Aspartate Receptor Encephalitis Following COVID-19 Vaccination: A Case Report

Anti-N-methyl D-aspartate (NMDA) receptor (anti-NMDAR) encephalitis has been reported after SARS-CoV-2 infection, but not after SARS-CoV-2 vaccination. We report the first known case of anti-NMDAR encephalitis after SARS-CoV-2 immunization in a young female presenting with acute psychosis, highlight...

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Autores principales:	Patrick Flannery, Ingrid Yang, Madjid Keyvani, George Sakoulas
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 vaccine NMDA-receptor encephalitis psychosis Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/975cc603cd7e4ce38dc2a638260992ed
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spelling	oai:doaj.org-article:975cc603cd7e4ce38dc2a638260992ed2021-11-04T06:17:03ZAcute Psychosis Due to Anti-N-Methyl D-Aspartate Receptor Encephalitis Following COVID-19 Vaccination: A Case Report1664-229510.3389/fneur.2021.764197https://doaj.org/article/975cc603cd7e4ce38dc2a638260992ed2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.764197/fullhttps://doaj.org/toc/1664-2295Anti-N-methyl D-aspartate (NMDA) receptor (anti-NMDAR) encephalitis has been reported after SARS-CoV-2 infection, but not after SARS-CoV-2 vaccination. We report the first known case of anti-NMDAR encephalitis after SARS-CoV-2 immunization in a young female presenting with acute psychosis, highlighting a rare potential immunological complication of vaccination against SARS-CoV-2 that is currently being distributed worldwide. The patient presented initially with anxiety and hypochondriacal delusions which progressed to psychosis and catatonia but returned to baseline with aggressive immunomodulatory therapy consisting of intravenous immunoglobulin, high-dose glucocorticoids, and rituximab. This study highlights that the workup of acute psychosis should include establishing a history of recent vaccination followed by a thorough neurological assessment, including for anti-NMDAR antibodies in blood and cerebrospinal fluid.Patrick FlanneryIngrid YangMadjid KeyvaniGeorge SakoulasGeorge SakoulasFrontiers Media S.A.articleCOVID-19vaccineNMDA-receptorencephalitispsychosisNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 vaccine NMDA-receptor encephalitis psychosis Neurology. Diseases of the nervous system RC346-429
spellingShingle	COVID-19 vaccine NMDA-receptor encephalitis psychosis Neurology. Diseases of the nervous system RC346-429 Patrick Flannery Ingrid Yang Madjid Keyvani George Sakoulas George Sakoulas Acute Psychosis Due to Anti-N-Methyl D-Aspartate Receptor Encephalitis Following COVID-19 Vaccination: A Case Report
description	Anti-N-methyl D-aspartate (NMDA) receptor (anti-NMDAR) encephalitis has been reported after SARS-CoV-2 infection, but not after SARS-CoV-2 vaccination. We report the first known case of anti-NMDAR encephalitis after SARS-CoV-2 immunization in a young female presenting with acute psychosis, highlighting a rare potential immunological complication of vaccination against SARS-CoV-2 that is currently being distributed worldwide. The patient presented initially with anxiety and hypochondriacal delusions which progressed to psychosis and catatonia but returned to baseline with aggressive immunomodulatory therapy consisting of intravenous immunoglobulin, high-dose glucocorticoids, and rituximab. This study highlights that the workup of acute psychosis should include establishing a history of recent vaccination followed by a thorough neurological assessment, including for anti-NMDAR antibodies in blood and cerebrospinal fluid.
format	article
author	Patrick Flannery Ingrid Yang Madjid Keyvani George Sakoulas George Sakoulas
author_facet	Patrick Flannery Ingrid Yang Madjid Keyvani George Sakoulas George Sakoulas
author_sort	Patrick Flannery
title	Acute Psychosis Due to Anti-N-Methyl D-Aspartate Receptor Encephalitis Following COVID-19 Vaccination: A Case Report
title_short	Acute Psychosis Due to Anti-N-Methyl D-Aspartate Receptor Encephalitis Following COVID-19 Vaccination: A Case Report
title_full	Acute Psychosis Due to Anti-N-Methyl D-Aspartate Receptor Encephalitis Following COVID-19 Vaccination: A Case Report
title_fullStr	Acute Psychosis Due to Anti-N-Methyl D-Aspartate Receptor Encephalitis Following COVID-19 Vaccination: A Case Report
title_full_unstemmed	Acute Psychosis Due to Anti-N-Methyl D-Aspartate Receptor Encephalitis Following COVID-19 Vaccination: A Case Report
title_sort	acute psychosis due to anti-n-methyl d-aspartate receptor encephalitis following covid-19 vaccination: a case report
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/975cc603cd7e4ce38dc2a638260992ed
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Acute Psychosis Due to Anti-N-Methyl D-Aspartate Receptor Encephalitis Following COVID-19 Vaccination: A Case Report

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