The Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a highly lethal type of malignancies that possesses great loss of life safety to human beings worldwide. However, few effective means of curing HCC exist and its specific molecular basis is still far from being fully elucidated. Activation of nuclear factor kappa B...

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Autores principales:	Yina Zhang, Jiajia Shao, Shuangshuang Li, Yanning Liu, Min Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	nuclear factor kappa B hepatocellular carcinoma microRNA long non-coding RNA chemoresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/97606ecd982a4403bda4241ce7b81d24
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spelling	oai:doaj.org-article:97606ecd982a4403bda4241ce7b81d242021-11-05T05:32:53ZThe Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma2234-943X10.3389/fonc.2021.775250https://doaj.org/article/97606ecd982a4403bda4241ce7b81d242021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.775250/fullhttps://doaj.org/toc/2234-943XHepatocellular carcinoma (HCC) is a highly lethal type of malignancies that possesses great loss of life safety to human beings worldwide. However, few effective means of curing HCC exist and its specific molecular basis is still far from being fully elucidated. Activation of nuclear factor kappa B (NF-κB), which is often observed in HCC, is considered to play a significant part in hepatocarcinogenesis and development. The emergence of regulatory non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), is a defining advance in cancer biology, and related research in this branch has yielded many diagnostic and therapeutic opportunities. Recent studies have suggested that regulatory ncRNAs act as inhibitors or activators in the initiation and progression of HCC by targeting components of NF-κB signaling or regulating NF-κB activity. In this review, we attach importance to the role and function of regulatory ncRNAs in NF-κB signaling of HCC and NF-κB-associated chemoresistance in HCC, then propose future research directions and challenges of regulatory ncRNAs mediated-regulation of NF-κB pathway in HCC.Yina ZhangJiajia ShaoShuangshuang LiYanning LiuMin ZhengFrontiers Media S.A.articlenuclear factor kappa Bhepatocellular carcinomamicroRNAlong non-coding RNAchemoresistanceNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nuclear factor kappa B hepatocellular carcinoma microRNA long non-coding RNA chemoresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	nuclear factor kappa B hepatocellular carcinoma microRNA long non-coding RNA chemoresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yina Zhang Jiajia Shao Shuangshuang Li Yanning Liu Min Zheng The Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma
description	Hepatocellular carcinoma (HCC) is a highly lethal type of malignancies that possesses great loss of life safety to human beings worldwide. However, few effective means of curing HCC exist and its specific molecular basis is still far from being fully elucidated. Activation of nuclear factor kappa B (NF-κB), which is often observed in HCC, is considered to play a significant part in hepatocarcinogenesis and development. The emergence of regulatory non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), is a defining advance in cancer biology, and related research in this branch has yielded many diagnostic and therapeutic opportunities. Recent studies have suggested that regulatory ncRNAs act as inhibitors or activators in the initiation and progression of HCC by targeting components of NF-κB signaling or regulating NF-κB activity. In this review, we attach importance to the role and function of regulatory ncRNAs in NF-κB signaling of HCC and NF-κB-associated chemoresistance in HCC, then propose future research directions and challenges of regulatory ncRNAs mediated-regulation of NF-κB pathway in HCC.
format	article
author	Yina Zhang Jiajia Shao Shuangshuang Li Yanning Liu Min Zheng
author_facet	Yina Zhang Jiajia Shao Shuangshuang Li Yanning Liu Min Zheng
author_sort	Yina Zhang
title	The Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma
title_short	The Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma
title_full	The Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma
title_fullStr	The Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma
title_full_unstemmed	The Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma
title_sort	crosstalk between regulatory non-coding rnas and nuclear factor kappa b in hepatocellular carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/97606ecd982a4403bda4241ce7b81d24
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The Crosstalk Between Regulatory Non-Coding RNAs and Nuclear Factor Kappa B in Hepatocellular Carcinoma

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