Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015.

<h4>Objectives</h4>Low-normal thyroid function is associated with numerous metabolic risk factors including insulin resistance (IR). Triglyceride-glucose (TyG) index is a new surrogate marker of IR calculated by fasting triglyceride and glucose levels. Here, we investigated the associati...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wonsuk Choi, Ji Yong Park, A Ram Hong, Jee Hee Yoon, Hee Kyung Kim, Ho-Cheol Kang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97613c376c2742edabf2ab2f201da2d4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:97613c376c2742edabf2ab2f201da2d4
record_format	dspace
spelling	oai:doaj.org-article:97613c376c2742edabf2ab2f201da2d42021-12-02T20:09:12ZAssociation between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015.1932-620310.1371/journal.pone.0254630https://doaj.org/article/97613c376c2742edabf2ab2f201da2d42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254630https://doaj.org/toc/1932-6203<h4>Objectives</h4>Low-normal thyroid function is associated with numerous metabolic risk factors including insulin resistance (IR). Triglyceride-glucose (TyG) index is a new surrogate marker of IR calculated by fasting triglyceride and glucose levels. Here, we investigated the association between thyroid function and TyG index in non-diabetic euthyroid adults.<h4>Methods</h4>This cross-sectional study was based on data from the Korean National Health and Nutritional Examination Survey 2015 including 1482 individuals (741 men and 741 women). Serum thyrotropin (TSH) and free thyroxine (fT4) levels were measured.<h4>Results</h4>After adjusting for confounders, there was an inverse relationship of TyG index with fT4 in men (β = -0.094, P = 0.009) and a positive relationship of TyG index with TSH in women (β = 0.078, P = 0.018). The lowest fT4 tertile in men (P = 0.001) and the highest TSH tertile in women (P = 0.010) exhibited increased TyG index after adjusting for confounders. The lowest fT4 tertile also showed increased homeostatic model assessment for IR (HOMA-IR) only in men (P = 0.006). Odds ratios (ORs) for the high TyG index, which was defined as the highest TyG quartile decreased in the highest and second highest tertile of fT4 in men (OR = 0.41 and OR = 0.45, respectively; P < 0.001) and increased in highest tertile of TSH in women (OR = 1.81, P = 0.031) after adjusting for confounders. The OR for high HOMA-IR defined as the highest HOMA-IR quartile was also lower in the highest and second highest fT4 tertiles in men (both OR = 0.47; P = 0.003).<h4>Conclusions</h4>This is the first study to suggest that TyG index is a good surrogate marker of IR in evaluating its relationship with thyroid function.Wonsuk ChoiJi Yong ParkA Ram HongJee Hee YoonHee Kyung KimHo-Cheol KangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254630 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wonsuk Choi Ji Yong Park A Ram Hong Jee Hee Yoon Hee Kyung Kim Ho-Cheol Kang Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015.
description	<h4>Objectives</h4>Low-normal thyroid function is associated with numerous metabolic risk factors including insulin resistance (IR). Triglyceride-glucose (TyG) index is a new surrogate marker of IR calculated by fasting triglyceride and glucose levels. Here, we investigated the association between thyroid function and TyG index in non-diabetic euthyroid adults.<h4>Methods</h4>This cross-sectional study was based on data from the Korean National Health and Nutritional Examination Survey 2015 including 1482 individuals (741 men and 741 women). Serum thyrotropin (TSH) and free thyroxine (fT4) levels were measured.<h4>Results</h4>After adjusting for confounders, there was an inverse relationship of TyG index with fT4 in men (β = -0.094, P = 0.009) and a positive relationship of TyG index with TSH in women (β = 0.078, P = 0.018). The lowest fT4 tertile in men (P = 0.001) and the highest TSH tertile in women (P = 0.010) exhibited increased TyG index after adjusting for confounders. The lowest fT4 tertile also showed increased homeostatic model assessment for IR (HOMA-IR) only in men (P = 0.006). Odds ratios (ORs) for the high TyG index, which was defined as the highest TyG quartile decreased in the highest and second highest tertile of fT4 in men (OR = 0.41 and OR = 0.45, respectively; P < 0.001) and increased in highest tertile of TSH in women (OR = 1.81, P = 0.031) after adjusting for confounders. The OR for high HOMA-IR defined as the highest HOMA-IR quartile was also lower in the highest and second highest fT4 tertiles in men (both OR = 0.47; P = 0.003).<h4>Conclusions</h4>This is the first study to suggest that TyG index is a good surrogate marker of IR in evaluating its relationship with thyroid function.
format	article
author	Wonsuk Choi Ji Yong Park A Ram Hong Jee Hee Yoon Hee Kyung Kim Ho-Cheol Kang
author_facet	Wonsuk Choi Ji Yong Park A Ram Hong Jee Hee Yoon Hee Kyung Kim Ho-Cheol Kang
author_sort	Wonsuk Choi
title	Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015.
title_short	Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015.
title_full	Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015.
title_fullStr	Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015.
title_full_unstemmed	Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015.
title_sort	association between triglyceride-glucose index and thyroid function in euthyroid adults: the korea national health and nutritional examination survey 2015.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/97613c376c2742edabf2ab2f201da2d4
work_keys_str_mv	AT wonsukchoi associationbetweentriglycerideglucoseindexandthyroidfunctionineuthyroidadultsthekoreanationalhealthandnutritionalexaminationsurvey2015 AT jiyongpark associationbetweentriglycerideglucoseindexandthyroidfunctionineuthyroidadultsthekoreanationalhealthandnutritionalexaminationsurvey2015 AT aramhong associationbetweentriglycerideglucoseindexandthyroidfunctionineuthyroidadultsthekoreanationalhealthandnutritionalexaminationsurvey2015 AT jeeheeyoon associationbetweentriglycerideglucoseindexandthyroidfunctionineuthyroidadultsthekoreanationalhealthandnutritionalexaminationsurvey2015 AT heekyungkim associationbetweentriglycerideglucoseindexandthyroidfunctionineuthyroidadultsthekoreanationalhealthandnutritionalexaminationsurvey2015 AT hocheolkang associationbetweentriglycerideglucoseindexandthyroidfunctionineuthyroidadultsthekoreanationalhealthandnutritionalexaminationsurvey2015
_version_	1718375137997225984

Association between triglyceride-glucose index and thyroid function in euthyroid adults: The Korea National Health and Nutritional Examination Survey 2015.

Ejemplares similares