Cellular connectomes as arbiters of local circuit models in the cerebral cortex

Large-scale connectomes from the mammalian brain are becoming available, but it remains unclear how informative these are for the distinction of circuit models. Here, the authors use connectome statistics to test competing models of local cortical circuits with approximate Bayesian computation.

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Detalles Bibliográficos
Autores principales: Emmanuel Klinger, Alessandro Motta, Carsten Marr, Fabian J. Theis, Moritz Helmstaedter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/976449bebfec47c3a21f9ec50a671ef2
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Descripción
Sumario:Large-scale connectomes from the mammalian brain are becoming available, but it remains unclear how informative these are for the distinction of circuit models. Here, the authors use connectome statistics to test competing models of local cortical circuits with approximate Bayesian computation.