A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction
Here, Ejemel et al. report the identification and characterization of a cross-neutralizing human IgA monoclonal antibody, named MAb362, that binds the receptor-binding domain of SARS-CoV-2 Spike, blocking its interaction with the ACE2 host receptor.
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/97644dca295e44a19fa5676282d05155 |
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oai:doaj.org-article:97644dca295e44a19fa5676282d051552021-12-02T15:10:51ZA cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction10.1038/s41467-020-18058-82041-1723https://doaj.org/article/97644dca295e44a19fa5676282d051552020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18058-8https://doaj.org/toc/2041-1723Here, Ejemel et al. report the identification and characterization of a cross-neutralizing human IgA monoclonal antibody, named MAb362, that binds the receptor-binding domain of SARS-CoV-2 Spike, blocking its interaction with the ACE2 host receptor.Monir EjemelQi LiShurong HouZachary A. SchillerJulia A. TreeAaron WallaceAlla AmcheslavskyNese Kurt YilmazKaren R. ButtigiegMichael J. ElmoreKerry GodwinNaomi CoombesJacqueline R. ToomeyRyan SchneiderAnudeep S. RamchettyBrianna J. CloseDa-Yuan ChenHasahn L. ConwayMohsan SaeedChandrashekar GanesaMiles W. CarrollLisa A. CavaciniMark S. KlempnerCelia A. SchifferYang WangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Monir Ejemel Qi Li Shurong Hou Zachary A. Schiller Julia A. Tree Aaron Wallace Alla Amcheslavsky Nese Kurt Yilmaz Karen R. Buttigieg Michael J. Elmore Kerry Godwin Naomi Coombes Jacqueline R. Toomey Ryan Schneider Anudeep S. Ramchetty Brianna J. Close Da-Yuan Chen Hasahn L. Conway Mohsan Saeed Chandrashekar Ganesa Miles W. Carroll Lisa A. Cavacini Mark S. Klempner Celia A. Schiffer Yang Wang A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction |
| description |
Here, Ejemel et al. report the identification and characterization of a cross-neutralizing human IgA monoclonal antibody, named MAb362, that binds the receptor-binding domain of SARS-CoV-2 Spike, blocking its interaction with the ACE2 host receptor. |
| format |
article |
| author |
Monir Ejemel Qi Li Shurong Hou Zachary A. Schiller Julia A. Tree Aaron Wallace Alla Amcheslavsky Nese Kurt Yilmaz Karen R. Buttigieg Michael J. Elmore Kerry Godwin Naomi Coombes Jacqueline R. Toomey Ryan Schneider Anudeep S. Ramchetty Brianna J. Close Da-Yuan Chen Hasahn L. Conway Mohsan Saeed Chandrashekar Ganesa Miles W. Carroll Lisa A. Cavacini Mark S. Klempner Celia A. Schiffer Yang Wang |
| author_facet |
Monir Ejemel Qi Li Shurong Hou Zachary A. Schiller Julia A. Tree Aaron Wallace Alla Amcheslavsky Nese Kurt Yilmaz Karen R. Buttigieg Michael J. Elmore Kerry Godwin Naomi Coombes Jacqueline R. Toomey Ryan Schneider Anudeep S. Ramchetty Brianna J. Close Da-Yuan Chen Hasahn L. Conway Mohsan Saeed Chandrashekar Ganesa Miles W. Carroll Lisa A. Cavacini Mark S. Klempner Celia A. Schiffer Yang Wang |
| author_sort |
Monir Ejemel |
| title |
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction |
| title_short |
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction |
| title_full |
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction |
| title_fullStr |
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction |
| title_full_unstemmed |
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction |
| title_sort |
cross-reactive human iga monoclonal antibody blocks sars-cov-2 spike-ace2 interaction |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/97644dca295e44a19fa5676282d05155 |
| work_keys_str_mv |
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