High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome

Abstract Plasma osteoprotegerin (OPG) and vascular smooth muscle cell (VSMC) derived extracellular vesicles (EVs) are important regulators in the process of vascular calcification (VC). In population studies, high levels of OPG are associated with events. In animal studies, however, high OPG levels...

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Autores principales:	Mirthe Dekker, Farahnaz Waissi, Max J. M. Silvis, Joelle V. Bennekom, Arjan H. Schoneveld, Robbert J. de Winter, Ivana Isgum, Nikolas Lessmann, Birgitta K. Velthuis, Gerard Pasterkamp, Arend Mosterd, Leo Timmers, Dominique P. V. de Kleijn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9765ad5d9fff425aa1f3521772d3c650
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spelling	oai:doaj.org-article:9765ad5d9fff425aa1f3521772d3c6502021-12-02T17:27:03ZHigh levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome10.1038/s41598-021-98177-42045-2322https://doaj.org/article/9765ad5d9fff425aa1f3521772d3c6502021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98177-4https://doaj.org/toc/2045-2322Abstract Plasma osteoprotegerin (OPG) and vascular smooth muscle cell (VSMC) derived extracellular vesicles (EVs) are important regulators in the process of vascular calcification (VC). In population studies, high levels of OPG are associated with events. In animal studies, however, high OPG levels result in reduction of VC. VSMC-derived EVs are assumed to be responsible for OPG transport and VC but this role has not been studied. For this, we investigated the association between OPG in plasma and circulating EVs with coronary artery calcium (CAC) as surrogate for VC in symptomatic patients. We retrospectively assessed 742 patients undergoing myocardial perfusion imaging (MPI). CAC scores were determined on the MPI-CT images using a previously developed automated algorithm. Levels of OPG were quantified in plasma and two EV-subpopulations (LDL and TEX), using an electrochemiluminescence immunoassay. Circulating levels of OPG were independently associated with CAC scores in plasma; OR 1.39 (95% CI 1.17–1.65), and both EV populations; EV-LDL; OR 1.51 (95% CI 1.27–1.80) and EV-TEX; OR 1.21 (95% CI 1.02–1.42). High levels of OPG in plasma were independently associated with CAC scores in this symptomatic patient cohort. High levels of EV-derived OPG showed the same positive association with CAC scores, suggesting that EV-derived OPG mirrors the same pathophysiological process as plasma OPG.Mirthe DekkerFarahnaz WaissiMax J. M. SilvisJoelle V. BennekomArjan H. SchoneveldRobbert J. de WinterIvana IsgumNikolas LessmannBirgitta K. VelthuisGerard PasterkampArend MosterdLeo TimmersDominique P. V. de KleijnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mirthe Dekker Farahnaz Waissi Max J. M. Silvis Joelle V. Bennekom Arjan H. Schoneveld Robbert J. de Winter Ivana Isgum Nikolas Lessmann Birgitta K. Velthuis Gerard Pasterkamp Arend Mosterd Leo Timmers Dominique P. V. de Kleijn High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome
description	Abstract Plasma osteoprotegerin (OPG) and vascular smooth muscle cell (VSMC) derived extracellular vesicles (EVs) are important regulators in the process of vascular calcification (VC). In population studies, high levels of OPG are associated with events. In animal studies, however, high OPG levels result in reduction of VC. VSMC-derived EVs are assumed to be responsible for OPG transport and VC but this role has not been studied. For this, we investigated the association between OPG in plasma and circulating EVs with coronary artery calcium (CAC) as surrogate for VC in symptomatic patients. We retrospectively assessed 742 patients undergoing myocardial perfusion imaging (MPI). CAC scores were determined on the MPI-CT images using a previously developed automated algorithm. Levels of OPG were quantified in plasma and two EV-subpopulations (LDL and TEX), using an electrochemiluminescence immunoassay. Circulating levels of OPG were independently associated with CAC scores in plasma; OR 1.39 (95% CI 1.17–1.65), and both EV populations; EV-LDL; OR 1.51 (95% CI 1.27–1.80) and EV-TEX; OR 1.21 (95% CI 1.02–1.42). High levels of OPG in plasma were independently associated with CAC scores in this symptomatic patient cohort. High levels of EV-derived OPG showed the same positive association with CAC scores, suggesting that EV-derived OPG mirrors the same pathophysiological process as plasma OPG.
format	article
author	Mirthe Dekker Farahnaz Waissi Max J. M. Silvis Joelle V. Bennekom Arjan H. Schoneveld Robbert J. de Winter Ivana Isgum Nikolas Lessmann Birgitta K. Velthuis Gerard Pasterkamp Arend Mosterd Leo Timmers Dominique P. V. de Kleijn
author_facet	Mirthe Dekker Farahnaz Waissi Max J. M. Silvis Joelle V. Bennekom Arjan H. Schoneveld Robbert J. de Winter Ivana Isgum Nikolas Lessmann Birgitta K. Velthuis Gerard Pasterkamp Arend Mosterd Leo Timmers Dominique P. V. de Kleijn
author_sort	Mirthe Dekker
title	High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome
title_short	High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome
title_full	High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome
title_fullStr	High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome
title_full_unstemmed	High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome
title_sort	high levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9765ad5d9fff425aa1f3521772d3c650
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High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome

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