O-GlcNAcylated p53 in the liver modulates hepatic glucose production
p53 regulates signalling pathways involved in metabolic homeostasis. Here the authors show that O-GlcNAcylation of p53 in the liver plays a key role in the physiological regulation of glucose homeostasis, potentially via controlling the expression of the gluconeogenic enzyme phosphoenolpyruvate carb...
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Nature Portfolio
2021
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oai:doaj.org-article:9769f87dfa1c4d5b90bfa5688f97fb4c2021-12-02T18:01:12ZO-GlcNAcylated p53 in the liver modulates hepatic glucose production10.1038/s41467-021-25390-02041-1723https://doaj.org/article/9769f87dfa1c4d5b90bfa5688f97fb4c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25390-0https://doaj.org/toc/2041-1723p53 regulates signalling pathways involved in metabolic homeostasis. Here the authors show that O-GlcNAcylation of p53 in the liver plays a key role in the physiological regulation of glucose homeostasis, potentially via controlling the expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase.Maria J. Gonzalez-RellanMarcos F. FondevilaUxia FernandezAmaia RodríguezMarta Varela-ReyChristelle Veyrat-DurebexSamuel SeoaneGaneko BernardoFernando Lopitz-OtsoaDavid Fernández-RamosJon BilbaoCristina IglesiasEva NovoaCristina AmeneiroAna SenraDaniel BeiroaJuan CuñarroMaria DP Chantada-VazquezMaria Garcia-VenceSusana B. BravoNatalia Da Silva LimaBegoña PorteiroCarmen CarneiroAnxo VidalSulay TovarTimo D. MüllerJohan FernoDiana GuallarMiguel FidalgoGuadalupe SabioStephan HerzigWon Ho YangJin Won ChoMaria Luz Martinez-ChantarRoman Perez-FernandezMiguel LópezCarlos DieguezJose M. MatoOscar MilletRoberto CoppariAshwin WoodhooGema FruhbeckRuben NogueirasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Maria J. Gonzalez-Rellan Marcos F. Fondevila Uxia Fernandez Amaia Rodríguez Marta Varela-Rey Christelle Veyrat-Durebex Samuel Seoane Ganeko Bernardo Fernando Lopitz-Otsoa David Fernández-Ramos Jon Bilbao Cristina Iglesias Eva Novoa Cristina Ameneiro Ana Senra Daniel Beiroa Juan Cuñarro Maria DP Chantada-Vazquez Maria Garcia-Vence Susana B. Bravo Natalia Da Silva Lima Begoña Porteiro Carmen Carneiro Anxo Vidal Sulay Tovar Timo D. Müller Johan Ferno Diana Guallar Miguel Fidalgo Guadalupe Sabio Stephan Herzig Won Ho Yang Jin Won Cho Maria Luz Martinez-Chantar Roman Perez-Fernandez Miguel López Carlos Dieguez Jose M. Mato Oscar Millet Roberto Coppari Ashwin Woodhoo Gema Fruhbeck Ruben Nogueiras O-GlcNAcylated p53 in the liver modulates hepatic glucose production |
| description |
p53 regulates signalling pathways involved in metabolic homeostasis. Here the authors show that O-GlcNAcylation of p53 in the liver plays a key role in the physiological regulation of glucose homeostasis, potentially via controlling the expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase. |
| format |
article |
| author |
Maria J. Gonzalez-Rellan Marcos F. Fondevila Uxia Fernandez Amaia Rodríguez Marta Varela-Rey Christelle Veyrat-Durebex Samuel Seoane Ganeko Bernardo Fernando Lopitz-Otsoa David Fernández-Ramos Jon Bilbao Cristina Iglesias Eva Novoa Cristina Ameneiro Ana Senra Daniel Beiroa Juan Cuñarro Maria DP Chantada-Vazquez Maria Garcia-Vence Susana B. Bravo Natalia Da Silva Lima Begoña Porteiro Carmen Carneiro Anxo Vidal Sulay Tovar Timo D. Müller Johan Ferno Diana Guallar Miguel Fidalgo Guadalupe Sabio Stephan Herzig Won Ho Yang Jin Won Cho Maria Luz Martinez-Chantar Roman Perez-Fernandez Miguel López Carlos Dieguez Jose M. Mato Oscar Millet Roberto Coppari Ashwin Woodhoo Gema Fruhbeck Ruben Nogueiras |
| author_facet |
Maria J. Gonzalez-Rellan Marcos F. Fondevila Uxia Fernandez Amaia Rodríguez Marta Varela-Rey Christelle Veyrat-Durebex Samuel Seoane Ganeko Bernardo Fernando Lopitz-Otsoa David Fernández-Ramos Jon Bilbao Cristina Iglesias Eva Novoa Cristina Ameneiro Ana Senra Daniel Beiroa Juan Cuñarro Maria DP Chantada-Vazquez Maria Garcia-Vence Susana B. Bravo Natalia Da Silva Lima Begoña Porteiro Carmen Carneiro Anxo Vidal Sulay Tovar Timo D. Müller Johan Ferno Diana Guallar Miguel Fidalgo Guadalupe Sabio Stephan Herzig Won Ho Yang Jin Won Cho Maria Luz Martinez-Chantar Roman Perez-Fernandez Miguel López Carlos Dieguez Jose M. Mato Oscar Millet Roberto Coppari Ashwin Woodhoo Gema Fruhbeck Ruben Nogueiras |
| author_sort |
Maria J. Gonzalez-Rellan |
| title |
O-GlcNAcylated p53 in the liver modulates hepatic glucose production |
| title_short |
O-GlcNAcylated p53 in the liver modulates hepatic glucose production |
| title_full |
O-GlcNAcylated p53 in the liver modulates hepatic glucose production |
| title_fullStr |
O-GlcNAcylated p53 in the liver modulates hepatic glucose production |
| title_full_unstemmed |
O-GlcNAcylated p53 in the liver modulates hepatic glucose production |
| title_sort |
o-glcnacylated p53 in the liver modulates hepatic glucose production |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/9769f87dfa1c4d5b90bfa5688f97fb4c |
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