A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma

Canine oral melanoma (COM) is a highly aggressive tumour associated with poor prognosis due to metastasis and resistance to conventional anti-cancer therapies. As with human mucosal melanoma, the mutational landscape is predominated by copy number aberrations and chromosomal structural variants, but...

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Autor principal:	Laura Hardwick
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	canine genetics melanoma malignant oral pathogenesis Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/976bf3f7af064a1a80c96dff4119402e
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spelling	oai:doaj.org-article:976bf3f7af064a1a80c96dff4119402e2021-11-25T19:12:12ZA Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma10.3390/vetsci81102862306-7381https://doaj.org/article/976bf3f7af064a1a80c96dff4119402e2021-11-01T00:00:00Zhttps://www.mdpi.com/2306-7381/8/11/286https://doaj.org/toc/2306-7381Canine oral melanoma (COM) is a highly aggressive tumour associated with poor prognosis due to metastasis and resistance to conventional anti-cancer therapies. As with human mucosal melanoma, the mutational landscape is predominated by copy number aberrations and chromosomal structural variants, but differences in study cohorts and/or tumour heterogeneity can lead to discordant results regarding the nature of specific genes affected. This review discusses somatic molecular alterations in COM that result from single nucleotide variations, copy number changes, chromosomal rearrangements, and/or dysregulation of small non-coding RNAs. A cross-species comparison highlights notable recurrent aberrations, and functionally grouping dysregulated proteins reveals unifying biological pathways that may be critical for oncogenesis and metastasis. Finally, potential therapeutic strategies are considered to target these pathways in canine patients, and the benefits of collaboration between science, medical, and veterinary communities are emphasised.Laura HardwickMDPI AGarticlecaninegeneticsmelanomamalignantoralpathogenesisVeterinary medicineSF600-1100ENVeterinary Sciences, Vol 8, Iss 286, p 286 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	canine genetics melanoma malignant oral pathogenesis Veterinary medicine SF600-1100
spellingShingle	canine genetics melanoma malignant oral pathogenesis Veterinary medicine SF600-1100 Laura Hardwick A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma
description	Canine oral melanoma (COM) is a highly aggressive tumour associated with poor prognosis due to metastasis and resistance to conventional anti-cancer therapies. As with human mucosal melanoma, the mutational landscape is predominated by copy number aberrations and chromosomal structural variants, but differences in study cohorts and/or tumour heterogeneity can lead to discordant results regarding the nature of specific genes affected. This review discusses somatic molecular alterations in COM that result from single nucleotide variations, copy number changes, chromosomal rearrangements, and/or dysregulation of small non-coding RNAs. A cross-species comparison highlights notable recurrent aberrations, and functionally grouping dysregulated proteins reveals unifying biological pathways that may be critical for oncogenesis and metastasis. Finally, potential therapeutic strategies are considered to target these pathways in canine patients, and the benefits of collaboration between science, medical, and veterinary communities are emphasised.
format	article
author	Laura Hardwick
author_facet	Laura Hardwick
author_sort	Laura Hardwick
title	A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma
title_short	A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma
title_full	A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma
title_fullStr	A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma
title_full_unstemmed	A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma
title_sort	comparative view on molecular alterations and potential therapeutic strategies for canine oral melanoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/976bf3f7af064a1a80c96dff4119402e
work_keys_str_mv	AT laurahardwick acomparativeviewonmolecularalterationsandpotentialtherapeuticstrategiesforcanineoralmelanoma AT laurahardwick comparativeviewonmolecularalterationsandpotentialtherapeuticstrategiesforcanineoralmelanoma
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A Comparative View on Molecular Alterations and Potential Therapeutic Strategies for Canine Oral Melanoma

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