The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study
Thierry Hamel,1,2 Justine Rheault,1,2 David Simonyan,3 Serge Bourgault,1,2,* Patrick J Rochette1,2,4,* 1Département d’ophtalmologie et d’ORL-CCF, Faculté de médecine, Université Laval, Québec, QC, Canada; 2Centre Universitair...
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Dove Medical Press
2021
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oai:doaj.org-article:976cfb77ee104f869fc9ba01d5c551b42021-12-02T14:39:27ZThe Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study1177-5483https://doaj.org/article/976cfb77ee104f869fc9ba01d5c551b42021-06-01T00:00:00Zhttps://www.dovepress.com/the-influence-of-blue-filtering-intraocular-lenses-implant-on-exudativ-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Thierry Hamel,1,2 Justine Rheault,1,2 David Simonyan,3 Serge Bourgault,1,2,* Patrick J Rochette1,2,4,* 1Département d’ophtalmologie et d’ORL-CCF, Faculté de médecine, Université Laval, Québec, QC, Canada; 2Centre Universitaire d’Ophtalmologie (CUO), Hôpital du Saint-Sacrement, CHU de Québec – Université Laval, Québec, QC, Canada; 3Clinical and Evaluative Research Platform, CHU de Québec-Université Laval Research Centre, Québec, QC, Canada; 4Centre de Recherche du CHU de Québec – Université Laval, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Québec, QC, Canada*These authors contributed equally to this workCorrespondence: Patrick J RochetteCentre de recherche du CHU de Québec – Université Laval, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Bureau H2-10, 1050 Chemin Sainte-Foy, Québec, QC, G1S 4L8, CanadaTel +1 418 682-7568Email Patrick-J.Rochette@crchudequebec.ulaval.caPurpose: To determine whether the use of a blue light-filtering intraocular lens (IOL) prevents the onset of wet age-related macular degeneration (AMD). More precisely, we examined the proportion of blue light-filtering IOL in a wet AMD patients’ sample and compared it with a general North American pseudophakic population sample.Design: Retrospective case–control study.Methods: Case patients were diagnosed and treated for wet AMD and had prior IOL implantation at least 3 years before the diagnosis of wet AMD. Control patients were randomly selected among patients who had cataract surgery at our institution. They were exempt of AMD and paired for the year of surgery, sex and age at cataract surgery. A total of 196 patients were included in each study group.Results: Among patients with wet AMD, 62.8% had a blue light-filtering IOL compared with 63.3% among control patients (p = 0.92). Mean time between implantation and injection of anti-VEGF in AMD patients was 6.62 years (95% confidence interval (CI): 6.04– 7.19) in non-blue light-filtering IOL group and 5.76 years (95% CI: 5.41– 6.11) in blue light-filtering IOL group (p = 0.0120).Conclusion: No correlations could be established between the presence of a blue light filter in the IOL and the occurrence of wet AMD. AMD patients without blue light-filtering IOL were injected significantly later than patients with an IOL filtering blue light, which contradict the potential clinical benefit of the blue light filter.Keywords: blue-light filter, intraocular lens, cataract surgery, age-related macular degeneration, anti-VEGF injectionHamel TRheault JSimonyan DBourgault SRochette PJDove Medical Pressarticleblue-light filterintraocular lenscataract surgeryage-related macular degenerationanti-vegf injectionOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2287-2292 (2021) |
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DOAJ |
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DOAJ |
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EN |
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blue-light filter intraocular lens cataract surgery age-related macular degeneration anti-vegf injection Ophthalmology RE1-994 |
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blue-light filter intraocular lens cataract surgery age-related macular degeneration anti-vegf injection Ophthalmology RE1-994 Hamel T Rheault J Simonyan D Bourgault S Rochette PJ The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study |
| description |
Thierry Hamel,1,2 Justine Rheault,1,2 David Simonyan,3 Serge Bourgault,1,2,* Patrick J Rochette1,2,4,* 1Département d’ophtalmologie et d’ORL-CCF, Faculté de médecine, Université Laval, Québec, QC, Canada; 2Centre Universitaire d’Ophtalmologie (CUO), Hôpital du Saint-Sacrement, CHU de Québec – Université Laval, Québec, QC, Canada; 3Clinical and Evaluative Research Platform, CHU de Québec-Université Laval Research Centre, Québec, QC, Canada; 4Centre de Recherche du CHU de Québec – Université Laval, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Québec, QC, Canada*These authors contributed equally to this workCorrespondence: Patrick J RochetteCentre de recherche du CHU de Québec – Université Laval, Axe Médecine Régénératrice, Hôpital du Saint-Sacrement, Bureau H2-10, 1050 Chemin Sainte-Foy, Québec, QC, G1S 4L8, CanadaTel +1 418 682-7568Email Patrick-J.Rochette@crchudequebec.ulaval.caPurpose: To determine whether the use of a blue light-filtering intraocular lens (IOL) prevents the onset of wet age-related macular degeneration (AMD). More precisely, we examined the proportion of blue light-filtering IOL in a wet AMD patients’ sample and compared it with a general North American pseudophakic population sample.Design: Retrospective case–control study.Methods: Case patients were diagnosed and treated for wet AMD and had prior IOL implantation at least 3 years before the diagnosis of wet AMD. Control patients were randomly selected among patients who had cataract surgery at our institution. They were exempt of AMD and paired for the year of surgery, sex and age at cataract surgery. A total of 196 patients were included in each study group.Results: Among patients with wet AMD, 62.8% had a blue light-filtering IOL compared with 63.3% among control patients (p = 0.92). Mean time between implantation and injection of anti-VEGF in AMD patients was 6.62 years (95% confidence interval (CI): 6.04– 7.19) in non-blue light-filtering IOL group and 5.76 years (95% CI: 5.41– 6.11) in blue light-filtering IOL group (p = 0.0120).Conclusion: No correlations could be established between the presence of a blue light filter in the IOL and the occurrence of wet AMD. AMD patients without blue light-filtering IOL were injected significantly later than patients with an IOL filtering blue light, which contradict the potential clinical benefit of the blue light filter.Keywords: blue-light filter, intraocular lens, cataract surgery, age-related macular degeneration, anti-VEGF injection |
| format |
article |
| author |
Hamel T Rheault J Simonyan D Bourgault S Rochette PJ |
| author_facet |
Hamel T Rheault J Simonyan D Bourgault S Rochette PJ |
| author_sort |
Hamel T |
| title |
The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study |
| title_short |
The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study |
| title_full |
The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study |
| title_fullStr |
The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study |
| title_full_unstemmed |
The Influence of Blue-Filtering Intraocular Lenses Implant on Exudative Age-Related Macular Degeneration: A Case–Control Study |
| title_sort |
influence of blue-filtering intraocular lenses implant on exudative age-related macular degeneration: a case–control study |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/976cfb77ee104f869fc9ba01d5c551b4 |
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