Predictors of Seronegative Conversion After Centralized Management of Syphilis Patients in Shenzhen, China

Objective: The aim of this study was to explore the seronegative conversion status of syphilis patients after centralized management and to analyze potential determinants.Materials and Methods: A retrospective population-based cohort study was conducted, and data for individuals who had been diagnos...

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Autores principales:	Zhenzhou Luo, Yi Ding, Jun Yuan, Qiuhong Wu, Lishan Tian, Li Zhang, Bo Li, Jinsong Mou
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	syphilis seroconversion Shenzhen China multivariable analysis TRUST titer Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/976dfada2cfd428fa42431003f4c795d
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spelling	oai:doaj.org-article:976dfada2cfd428fa42431003f4c795d2021-11-30T23:56:33ZPredictors of Seronegative Conversion After Centralized Management of Syphilis Patients in Shenzhen, China2296-256510.3389/fpubh.2021.755037https://doaj.org/article/976dfada2cfd428fa42431003f4c795d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.755037/fullhttps://doaj.org/toc/2296-2565Objective: The aim of this study was to explore the seronegative conversion status of syphilis patients after centralized management and to analyze potential determinants.Materials and Methods: A retrospective population-based cohort study was conducted, and data for individuals who had been diagnosed with syphilis between 2011 and 2019 were retrieved from the Shenzhen Nanshan Center for Chronic Disease Control. Seroconversion statuses were summarized as percentages. Univariable and multiple Cox proportional hazard regression models were used to analyze the factors associated with seronegative conversion among syphilis patients.Results: During the study period, 1,545 patients with syphilis participated in the syphilis convergence case management program on a voluntary basis, of whom 290 were excluded due to missing follow-up data. A total of 27.6% (346/1255) of patients with syphilis showed seronegative conversion. Multivariable analysis revealed that the following significantly determined syphilis seroconversion from positive to negative: younger age (15–19 years vs. ≥30 years: HR = 2.18), male gender (HR = 1.45), lower baseline toluidine red unheated serum test (TRUST) titer of ≤ 1:8 (HR = 2.23), and different disease stages, including latent syphilis (HR = 1.98), primary syphilis (HR = 7.67), and secondary syphilis (HR = 4.83).Conclusions: Few patients with syphilis tested negative after treatment at the end of the study. Seronegative conversion in the patients was associated with age, sex, baseline TRUST titer, and syphilis stage.Zhenzhou LuoYi DingJun YuanQiuhong WuLishan TianLi ZhangBo LiJinsong MouFrontiers Media S.A.articlesyphilisseroconversionShenzhenChinamultivariable analysisTRUST titerPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	syphilis seroconversion Shenzhen China multivariable analysis TRUST titer Public aspects of medicine RA1-1270
spellingShingle	syphilis seroconversion Shenzhen China multivariable analysis TRUST titer Public aspects of medicine RA1-1270 Zhenzhou Luo Yi Ding Jun Yuan Qiuhong Wu Lishan Tian Li Zhang Bo Li Jinsong Mou Predictors of Seronegative Conversion After Centralized Management of Syphilis Patients in Shenzhen, China
description	Objective: The aim of this study was to explore the seronegative conversion status of syphilis patients after centralized management and to analyze potential determinants.Materials and Methods: A retrospective population-based cohort study was conducted, and data for individuals who had been diagnosed with syphilis between 2011 and 2019 were retrieved from the Shenzhen Nanshan Center for Chronic Disease Control. Seroconversion statuses were summarized as percentages. Univariable and multiple Cox proportional hazard regression models were used to analyze the factors associated with seronegative conversion among syphilis patients.Results: During the study period, 1,545 patients with syphilis participated in the syphilis convergence case management program on a voluntary basis, of whom 290 were excluded due to missing follow-up data. A total of 27.6% (346/1255) of patients with syphilis showed seronegative conversion. Multivariable analysis revealed that the following significantly determined syphilis seroconversion from positive to negative: younger age (15–19 years vs. ≥30 years: HR = 2.18), male gender (HR = 1.45), lower baseline toluidine red unheated serum test (TRUST) titer of ≤ 1:8 (HR = 2.23), and different disease stages, including latent syphilis (HR = 1.98), primary syphilis (HR = 7.67), and secondary syphilis (HR = 4.83).Conclusions: Few patients with syphilis tested negative after treatment at the end of the study. Seronegative conversion in the patients was associated with age, sex, baseline TRUST titer, and syphilis stage.
format	article
author	Zhenzhou Luo Yi Ding Jun Yuan Qiuhong Wu Lishan Tian Li Zhang Bo Li Jinsong Mou
author_facet	Zhenzhou Luo Yi Ding Jun Yuan Qiuhong Wu Lishan Tian Li Zhang Bo Li Jinsong Mou
author_sort	Zhenzhou Luo
title	Predictors of Seronegative Conversion After Centralized Management of Syphilis Patients in Shenzhen, China
title_short	Predictors of Seronegative Conversion After Centralized Management of Syphilis Patients in Shenzhen, China
title_full	Predictors of Seronegative Conversion After Centralized Management of Syphilis Patients in Shenzhen, China
title_fullStr	Predictors of Seronegative Conversion After Centralized Management of Syphilis Patients in Shenzhen, China
title_full_unstemmed	Predictors of Seronegative Conversion After Centralized Management of Syphilis Patients in Shenzhen, China
title_sort	predictors of seronegative conversion after centralized management of syphilis patients in shenzhen, china
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/976dfada2cfd428fa42431003f4c795d
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Predictors of Seronegative Conversion After Centralized Management of Syphilis Patients in Shenzhen, China

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