Novel ecto-tagged integrins reveal their trafficking in live cells

Integrins are cell-surface adhesion receptors that are modulated by endo-exocytic trafficking, but existing tools to study this process can interfere with function. Here the authors develop β1 integrins carrying traceable tags in the extracellular domain; a pH-sensitive pHlourin tag or a HaloTag to...

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Autores principales:	Clotilde Huet-Calderwood, Felix Rivera-Molina, Daniel V. Iwamoto, Emil B. Kromann, Derek Toomre, David A. Calderwood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97783d23504d4b7c8a85d54e3bfbedbf
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spelling	oai:doaj.org-article:97783d23504d4b7c8a85d54e3bfbedbf2021-12-02T15:38:46ZNovel ecto-tagged integrins reveal their trafficking in live cells10.1038/s41467-017-00646-w2041-1723https://doaj.org/article/97783d23504d4b7c8a85d54e3bfbedbf2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00646-whttps://doaj.org/toc/2041-1723Integrins are cell-surface adhesion receptors that are modulated by endo-exocytic trafficking, but existing tools to study this process can interfere with function. Here the authors develop β1 integrins carrying traceable tags in the extracellular domain; a pH-sensitive pHlourin tag or a HaloTag to facilitate dye attachment.Clotilde Huet-CalderwoodFelix Rivera-MolinaDaniel V. IwamotoEmil B. KromannDerek ToomreDavid A. CalderwoodNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clotilde Huet-Calderwood Felix Rivera-Molina Daniel V. Iwamoto Emil B. Kromann Derek Toomre David A. Calderwood Novel ecto-tagged integrins reveal their trafficking in live cells
description	Integrins are cell-surface adhesion receptors that are modulated by endo-exocytic trafficking, but existing tools to study this process can interfere with function. Here the authors develop β1 integrins carrying traceable tags in the extracellular domain; a pH-sensitive pHlourin tag or a HaloTag to facilitate dye attachment.
format	article
author	Clotilde Huet-Calderwood Felix Rivera-Molina Daniel V. Iwamoto Emil B. Kromann Derek Toomre David A. Calderwood
author_facet	Clotilde Huet-Calderwood Felix Rivera-Molina Daniel V. Iwamoto Emil B. Kromann Derek Toomre David A. Calderwood
author_sort	Clotilde Huet-Calderwood
title	Novel ecto-tagged integrins reveal their trafficking in live cells
title_short	Novel ecto-tagged integrins reveal their trafficking in live cells
title_full	Novel ecto-tagged integrins reveal their trafficking in live cells
title_fullStr	Novel ecto-tagged integrins reveal their trafficking in live cells
title_full_unstemmed	Novel ecto-tagged integrins reveal their trafficking in live cells
title_sort	novel ecto-tagged integrins reveal their trafficking in live cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/97783d23504d4b7c8a85d54e3bfbedbf
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Novel ecto-tagged integrins reveal their trafficking in live cells

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