Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure

Aim. To determine the effect of combined therapy with nebivolol or carvedilol on the functional state of patients with diastolic chronic heart failure (CHF). Material and methods. The study involved 68 patients with CHF and preserved left ventricular ejection fraction, who were randomized into tw...

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Autores principales:	Vitalii G. Tregubov, Pavel V. Khil′kevich, Iosif Z. Shubitidze, Anna V. Tregubova
Formato:	article
Lenguaje:	EN RU
Publicado:	Concilium Medicum 2021
Materias:	chronic heart failure nebivolol carvedilol functional state regulatory-adaptive status Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/97784ce1d6f444d1b8d37ea9d1c511a2
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spelling	oai:doaj.org-article:97784ce1d6f444d1b8d37ea9d1c511a22021-12-01T22:07:01ZAssessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure2221-71852658-570710.26442/22217185.2020.4.200565https://doaj.org/article/97784ce1d6f444d1b8d37ea9d1c511a22021-02-01T00:00:00Zhttps://cardiosomatics.orscience.ru/2221-7185/article/viewFile/60807/43924https://doaj.org/toc/2221-7185https://doaj.org/toc/2658-5707Aim. To determine the effect of combined therapy with nebivolol or carvedilol on the functional state of patients with diastolic chronic heart failure (CHF). Material and methods. The study involved 68 patients with CHF and preserved left ventricular ejection fraction, who were randomized into two groups for treatment with bisoprolol or carvedilol. As part of the combination therapy was prescribed quinapril, and if indicated atorvastatin, acetylsalicylic acid in the intestinal soluble shell. Initially and after 24 weeks of therapy were carried out: quantitative assessment of regulatory-adaptive status (RAS), echocardioscopy, treadmill test, six-minute walking test, subjective assessment of quality of life, determination of level of N-terminal fragment of the brain natriuretic peptide precursor in blood plasma. Results. Both schemes of combined therapy comparably improved the morpho-functional parameters of the heart and quality of life. In comparison with carvedilol, nebivolol more pronouncedly increased RAS and tolerance to physical activity. Conclusion. In patients with diastolic CHF in combination therapy, the use of nebivolol, in comparison with carvedilol, may be preferable due to the positive effect on the functional state.Vitalii G. TregubovPavel V. Khil′kevichIosif Z. ShubitidzeAnna V. TregubovaConcilium Medicumarticlechronic heart failurenebivololcarvedilolfunctional stateregulatory-adaptive statusDiseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENRUКардиоСоматика, Vol 11, Iss 4, Pp 25-29 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	chronic heart failure nebivolol carvedilol functional state regulatory-adaptive status Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	chronic heart failure nebivolol carvedilol functional state regulatory-adaptive status Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Vitalii G. Tregubov Pavel V. Khil′kevich Iosif Z. Shubitidze Anna V. Tregubova Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure
description	Aim. To determine the effect of combined therapy with nebivolol or carvedilol on the functional state of patients with diastolic chronic heart failure (CHF). Material and methods. The study involved 68 patients with CHF and preserved left ventricular ejection fraction, who were randomized into two groups for treatment with bisoprolol or carvedilol. As part of the combination therapy was prescribed quinapril, and if indicated atorvastatin, acetylsalicylic acid in the intestinal soluble shell. Initially and after 24 weeks of therapy were carried out: quantitative assessment of regulatory-adaptive status (RAS), echocardioscopy, treadmill test, six-minute walking test, subjective assessment of quality of life, determination of level of N-terminal fragment of the brain natriuretic peptide precursor in blood plasma. Results. Both schemes of combined therapy comparably improved the morpho-functional parameters of the heart and quality of life. In comparison with carvedilol, nebivolol more pronouncedly increased RAS and tolerance to physical activity. Conclusion. In patients with diastolic CHF in combination therapy, the use of nebivolol, in comparison with carvedilol, may be preferable due to the positive effect on the functional state.
format	article
author	Vitalii G. Tregubov Pavel V. Khil′kevich Iosif Z. Shubitidze Anna V. Tregubova
author_facet	Vitalii G. Tregubov Pavel V. Khil′kevich Iosif Z. Shubitidze Anna V. Tregubova
author_sort	Vitalii G. Tregubov
title	Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure
title_short	Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure
title_full	Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure
title_fullStr	Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure
title_full_unstemmed	Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure
title_sort	assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure
publisher	Concilium Medicum
publishDate	2021
url	https://doaj.org/article/97784ce1d6f444d1b8d37ea9d1c511a2
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Assessment of the effect of nebivolol and сarvedilol on the functional state of patients with diastolic chronic heart failure

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