Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity.

<h4>Background</h4>Acinetobacter baumannii is an emerging bacterial pathogen that causes a broad array of infections, particularly in hospitalized patients. Many studies have focused on the epidemiology and antibiotic resistance of A. baumannii, but little is currently known with respect...

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Autores principales:	Luísa C S Antunes, Francesco Imperi, Alessandra Carattoli, Paolo Visca
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9778a8a73ea94911920171d5e5defa0e
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spelling	oai:doaj.org-article:9778a8a73ea94911920171d5e5defa0e2021-11-18T06:48:55ZDeciphering the multifactorial nature of Acinetobacter baumannii pathogenicity.1932-620310.1371/journal.pone.0022674https://doaj.org/article/9778a8a73ea94911920171d5e5defa0e2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21829642/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Acinetobacter baumannii is an emerging bacterial pathogen that causes a broad array of infections, particularly in hospitalized patients. Many studies have focused on the epidemiology and antibiotic resistance of A. baumannii, but little is currently known with respect to its virulence potential.<h4>Methodology/principal findings</h4>The aim of this work was to analyze a number of virulence-related traits of four A. baumannii strains of different origin and clinical impact for which complete genome sequences were available, in order to tentatively identify novel determinants of A. baumannii pathogenicity. Clinical strains showed comparable virulence in the Galleria mellonella model of infection, irrespective of their status as outbreak or sporadic strains, whereas a non-human isolate was avirulent. A combined approach of genomic and phenotypic analyses led to the identification of several virulence factors, including exoproducts with hemolytic, phospholipase, protease and iron-chelating activities, as well as a number of multifactorial phenotypes, such as biofilm formation, surface motility and stress resistance, which were differentially expressed and could play a role in A. baumannii pathogenicity.<h4>Conclusion/significance</h4>This work provides evidence of the multifactorial nature of A. baumannii virulence. While A. baumannii clinical isolates could represent a selected population of strains adapted to infect the human host, subpopulations of highly genotypically and phenotypically diverse A. baumannii strains may exist outside the hospital environment, whose relevance and distribution deserve further investigation.Luísa C S AntunesFrancesco ImperiAlessandra CarattoliPaolo ViscaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e22674 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luísa C S Antunes Francesco Imperi Alessandra Carattoli Paolo Visca Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity.
description	<h4>Background</h4>Acinetobacter baumannii is an emerging bacterial pathogen that causes a broad array of infections, particularly in hospitalized patients. Many studies have focused on the epidemiology and antibiotic resistance of A. baumannii, but little is currently known with respect to its virulence potential.<h4>Methodology/principal findings</h4>The aim of this work was to analyze a number of virulence-related traits of four A. baumannii strains of different origin and clinical impact for which complete genome sequences were available, in order to tentatively identify novel determinants of A. baumannii pathogenicity. Clinical strains showed comparable virulence in the Galleria mellonella model of infection, irrespective of their status as outbreak or sporadic strains, whereas a non-human isolate was avirulent. A combined approach of genomic and phenotypic analyses led to the identification of several virulence factors, including exoproducts with hemolytic, phospholipase, protease and iron-chelating activities, as well as a number of multifactorial phenotypes, such as biofilm formation, surface motility and stress resistance, which were differentially expressed and could play a role in A. baumannii pathogenicity.<h4>Conclusion/significance</h4>This work provides evidence of the multifactorial nature of A. baumannii virulence. While A. baumannii clinical isolates could represent a selected population of strains adapted to infect the human host, subpopulations of highly genotypically and phenotypically diverse A. baumannii strains may exist outside the hospital environment, whose relevance and distribution deserve further investigation.
format	article
author	Luísa C S Antunes Francesco Imperi Alessandra Carattoli Paolo Visca
author_facet	Luísa C S Antunes Francesco Imperi Alessandra Carattoli Paolo Visca
author_sort	Luísa C S Antunes
title	Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity.
title_short	Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity.
title_full	Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity.
title_fullStr	Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity.
title_full_unstemmed	Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity.
title_sort	deciphering the multifactorial nature of acinetobacter baumannii pathogenicity.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/9778a8a73ea94911920171d5e5defa0e
work_keys_str_mv	AT luisacsantunes decipheringthemultifactorialnatureofacinetobacterbaumanniipathogenicity AT francescoimperi decipheringthemultifactorialnatureofacinetobacterbaumanniipathogenicity AT alessandracarattoli decipheringthemultifactorialnatureofacinetobacterbaumanniipathogenicity AT paolovisca decipheringthemultifactorialnatureofacinetobacterbaumanniipathogenicity
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Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity.

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