Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus

Abstract The purpose of this study was to evaluate corneal epithelium and stromal remodelling with anterior segment optical coherence tomography in patients who have undergone stromal lenticule addition keratoplasty (SLAK) for advanced keratoconus. This was a prospective non-comparative observationa...

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Autores principales:	Mario Nubile, Niccolò Salgari, Jodhbir S. Mehta, Roberta Calienno, Emanuele Erroi, Jessica Bondì, Manuela Lanzini, Yu-Chi Liu, Leonardo Mastropasqua
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/977c6042e57a4515b54fc931df742f54
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spelling	oai:doaj.org-article:977c6042e57a4515b54fc931df742f542021-12-02T13:23:58ZEpithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus10.1038/s41598-021-81626-52045-2322https://doaj.org/article/977c6042e57a4515b54fc931df742f542021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81626-5https://doaj.org/toc/2045-2322Abstract The purpose of this study was to evaluate corneal epithelium and stromal remodelling with anterior segment optical coherence tomography in patients who have undergone stromal lenticule addition keratoplasty (SLAK) for advanced keratoconus. This was a prospective non-comparative observational study. Fifteen eyes of 15 patients with advanced keratoconus underwent implantation with a cadaveric, donor negative meniscus-shaped intrastromal lenticule, produced with a femtosecond laser, into a stromal pocket dissected in the recipient cornea at a depth of 120 μm. Simulated keratometry, central corneal thickness (CTT), corneal thinnest point (CTP), central epithelial thickness (CET), central and peripheral lenticule thickness, anterior and posterior stromal thickness were measured. Regional central corneal epithelial thickness (CET) and variations in the inner annular area (IAT) and outer annular area (OAT) were also analysed. All parameters were measured preoperatively and 1, 3, and 6 months postoperatively. The average anterior Sim-k decreased from 59.63 ± 7.58 preoperatively to 57.19 ± 6.33 D 6 months postoperatively. CCT, CTP, CET, and OAT increased and IAT decreased significantly after 1 month. All parameters appeared unchanged at 6-months except that of OAT that further increased. Lenticule thickness was stable. In conclusion we observed that SLAK reshapes the cornea by central flattening with stromal thickening and epithelial thickness restoration.Mario NubileNiccolò SalgariJodhbir S. MehtaRoberta CaliennoEmanuele ErroiJessica BondìManuela LanziniYu-Chi LiuLeonardo MastropasquaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mario Nubile Niccolò Salgari Jodhbir S. Mehta Roberta Calienno Emanuele Erroi Jessica Bondì Manuela Lanzini Yu-Chi Liu Leonardo Mastropasqua Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus
description	Abstract The purpose of this study was to evaluate corneal epithelium and stromal remodelling with anterior segment optical coherence tomography in patients who have undergone stromal lenticule addition keratoplasty (SLAK) for advanced keratoconus. This was a prospective non-comparative observational study. Fifteen eyes of 15 patients with advanced keratoconus underwent implantation with a cadaveric, donor negative meniscus-shaped intrastromal lenticule, produced with a femtosecond laser, into a stromal pocket dissected in the recipient cornea at a depth of 120 μm. Simulated keratometry, central corneal thickness (CTT), corneal thinnest point (CTP), central epithelial thickness (CET), central and peripheral lenticule thickness, anterior and posterior stromal thickness were measured. Regional central corneal epithelial thickness (CET) and variations in the inner annular area (IAT) and outer annular area (OAT) were also analysed. All parameters were measured preoperatively and 1, 3, and 6 months postoperatively. The average anterior Sim-k decreased from 59.63 ± 7.58 preoperatively to 57.19 ± 6.33 D 6 months postoperatively. CCT, CTP, CET, and OAT increased and IAT decreased significantly after 1 month. All parameters appeared unchanged at 6-months except that of OAT that further increased. Lenticule thickness was stable. In conclusion we observed that SLAK reshapes the cornea by central flattening with stromal thickening and epithelial thickness restoration.
format	article
author	Mario Nubile Niccolò Salgari Jodhbir S. Mehta Roberta Calienno Emanuele Erroi Jessica Bondì Manuela Lanzini Yu-Chi Liu Leonardo Mastropasqua
author_facet	Mario Nubile Niccolò Salgari Jodhbir S. Mehta Roberta Calienno Emanuele Erroi Jessica Bondì Manuela Lanzini Yu-Chi Liu Leonardo Mastropasqua
author_sort	Mario Nubile
title	Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus
title_short	Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus
title_full	Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus
title_fullStr	Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus
title_full_unstemmed	Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus
title_sort	epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (slak) for keratoconus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/977c6042e57a4515b54fc931df742f54
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Epithelial and stromal remodelling following femtosecond laser–assisted stromal lenticule addition keratoplasty (SLAK) for keratoconus

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