Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes

Abstract This study aimed to analyze the interaction of primaquine (PQ), chloroquine (CQ), and liposomes to support the design of optimal liposomal delivery for hepatic stage malaria infectious disease. The liposomes were composed of hydrogenated soybean phosphatidylcholine, cholesterol, and distear...

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Autores principales:	Andang Miatmoko, Ira Nurjannah, Nuril Fadilatul Nehru, Noorma Rosita, Esti Hendradi, Retno Sari, Juni Ekowati
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/977cef74f22c490a8ab57512a9335519
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spelling	oai:doaj.org-article:977cef74f22c490a8ab57512a93355192021-12-02T16:04:26ZInteractions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes10.1038/s41598-021-91866-02045-2322https://doaj.org/article/977cef74f22c490a8ab57512a93355192021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91866-0https://doaj.org/toc/2045-2322Abstract This study aimed to analyze the interaction of primaquine (PQ), chloroquine (CQ), and liposomes to support the design of optimal liposomal delivery for hepatic stage malaria infectious disease. The liposomes were composed of hydrogenated soybean phosphatidylcholine, cholesterol, and distearoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy[polyethyleneglycol]-2000), prepared by thin film method, then evaluated for physicochemical and spectrospic characteristics. The calcein release was further evaluated to determine the effect of drug co-loading on liposomal membrane integrity. The results showed that loading PQ and CQ into liposomes produced changes in the infrared spectra of the diester phosphate and carbonyl ester located in the polar part of the phospholipid, in addition to the alkyl group (CH2) in the nonpolar portion. Moreover, the thermogram revealed the loss of the endothermic peak of liposomes dually loaded with PQ and CQ at 186.6 °C, which is identical to that of the phospholipid. However, no crystallinity changes were detected through powder X-ray diffraction analysis. Moreover, PQ, with either single or dual loading, produced the higher calcein release profiles from the liposomes than that of CQ. The dual loading of PQ and CQ tends to interact with the polar head group of the phosphatidylcholine bilayer membrane resulted in an increase in water permeability of the liposomes.Andang MiatmokoIra NurjannahNuril Fadilatul NehruNoorma RositaEsti HendradiRetno SariJuni EkowatiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andang Miatmoko Ira Nurjannah Nuril Fadilatul Nehru Noorma Rosita Esti Hendradi Retno Sari Juni Ekowati Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes
description	Abstract This study aimed to analyze the interaction of primaquine (PQ), chloroquine (CQ), and liposomes to support the design of optimal liposomal delivery for hepatic stage malaria infectious disease. The liposomes were composed of hydrogenated soybean phosphatidylcholine, cholesterol, and distearoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy[polyethyleneglycol]-2000), prepared by thin film method, then evaluated for physicochemical and spectrospic characteristics. The calcein release was further evaluated to determine the effect of drug co-loading on liposomal membrane integrity. The results showed that loading PQ and CQ into liposomes produced changes in the infrared spectra of the diester phosphate and carbonyl ester located in the polar part of the phospholipid, in addition to the alkyl group (CH2) in the nonpolar portion. Moreover, the thermogram revealed the loss of the endothermic peak of liposomes dually loaded with PQ and CQ at 186.6 °C, which is identical to that of the phospholipid. However, no crystallinity changes were detected through powder X-ray diffraction analysis. Moreover, PQ, with either single or dual loading, produced the higher calcein release profiles from the liposomes than that of CQ. The dual loading of PQ and CQ tends to interact with the polar head group of the phosphatidylcholine bilayer membrane resulted in an increase in water permeability of the liposomes.
format	article
author	Andang Miatmoko Ira Nurjannah Nuril Fadilatul Nehru Noorma Rosita Esti Hendradi Retno Sari Juni Ekowati
author_facet	Andang Miatmoko Ira Nurjannah Nuril Fadilatul Nehru Noorma Rosita Esti Hendradi Retno Sari Juni Ekowati
author_sort	Andang Miatmoko
title	Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes
title_short	Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes
title_full	Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes
title_fullStr	Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes
title_full_unstemmed	Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes
title_sort	interactions of primaquine and chloroquine with pegylated phosphatidylcholine liposomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/977cef74f22c490a8ab57512a9335519
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Interactions of primaquine and chloroquine with PEGylated﻿ phosphatidylcholine liposomes

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Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes