An Evolutionarily Conserved Mechanism for Intrinsic and Transferable Polymyxin Resistance

ABSTRACT Polymyxins, a family of cationic antimicrobial cyclic peptides, act as a last line of defense against severe infections by Gram-negative pathogens with carbapenem resistance. In addition to the intrinsic resistance to polymyxin E (colistin) conferred by Neisseria eptA, the plasmid-borne mob...

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Autores principales: Yongchang Xu, Wenhui Wei, Sheng Lei, Jingxia Lin, Swaminath Srinivas, Youjun Feng
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
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Acceso en línea:https://doaj.org/article/977dbc397dc24d05840738adaebbe8c4
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