Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study

Abstract To examine the use of anterior segment-optical coherence tomography angiography (AS-OCTA) in the assessment of limbal ischemia in an animal model chemical ocular injury. We conducted a prospective study using an established chemical ocular injury model in 6 rabbits (12 eyes), dividing the c...

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Autores principales:	Kai Yuan Tey, Jinyuan Gan, Valencia Foo, Bingyao Tan, Meng Yuan Ke, Leopold Schmetterer, Jodhbir S. Mehta, Marcus Ang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/977eabf154cd4eacab32359c1ef28aa3
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spelling	oai:doaj.org-article:977eabf154cd4eacab32359c1ef28aa32021-12-02T17:08:44ZRole of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study10.1038/s41598-021-96086-02045-2322https://doaj.org/article/977eabf154cd4eacab32359c1ef28aa32021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96086-0https://doaj.org/toc/2045-2322Abstract To examine the use of anterior segment-optical coherence tomography angiography (AS-OCTA) in the assessment of limbal ischemia in an animal model chemical ocular injury. We conducted a prospective study using an established chemical ocular injury model in 6 rabbits (12 eyes), dividing the cornea limbus into 4 quadrants. Chemical injury grade was induced based on extent of limbal injury (0 to 360 degrees) and all eyes underwent serial slit-lamp with AS-OCTA imaging up to one month. Main outcome measure was changes in AS-OCTA vessel density (VD) comparing injured and control cornea limbal quadrants within 24 h and at one month. AS-OCTA was able to detect differences in limbal VD reduction comparing injured (3.3 ± 2.4%) and control quadrants (7.6 ± 2.3%; p < 0.001) within 24 h of ocular chemical injury. We also observed that AS-OCTA VD reduction was highly correlated with the number of quadrants injured (r = − 0.89; p < 0.001; 95% CI − 5.65 to − 1.87). Corneal vascularization was detected by AS-OCTA in injured compared to control quadrants (10.1 ± 4.3% vs 7.0 ± 1.2%; p = 0.025) at 1 month. Our animal pilot study suggests that AS-OCTA was able to detect limbal vessel disruption from various severities of acute chemical insult, and in the future, could potentially serve as an adjunct in providing objective grading of acute ocular chemical injury once validated in a clinical trial.Kai Yuan TeyJinyuan GanValencia FooBingyao TanMeng Yuan KeLeopold SchmettererJodhbir S. MehtaMarcus AngNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kai Yuan Tey Jinyuan Gan Valencia Foo Bingyao Tan Meng Yuan Ke Leopold Schmetterer Jodhbir S. Mehta Marcus Ang Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study
description	Abstract To examine the use of anterior segment-optical coherence tomography angiography (AS-OCTA) in the assessment of limbal ischemia in an animal model chemical ocular injury. We conducted a prospective study using an established chemical ocular injury model in 6 rabbits (12 eyes), dividing the cornea limbus into 4 quadrants. Chemical injury grade was induced based on extent of limbal injury (0 to 360 degrees) and all eyes underwent serial slit-lamp with AS-OCTA imaging up to one month. Main outcome measure was changes in AS-OCTA vessel density (VD) comparing injured and control cornea limbal quadrants within 24 h and at one month. AS-OCTA was able to detect differences in limbal VD reduction comparing injured (3.3 ± 2.4%) and control quadrants (7.6 ± 2.3%; p < 0.001) within 24 h of ocular chemical injury. We also observed that AS-OCTA VD reduction was highly correlated with the number of quadrants injured (r = − 0.89; p < 0.001; 95% CI − 5.65 to − 1.87). Corneal vascularization was detected by AS-OCTA in injured compared to control quadrants (10.1 ± 4.3% vs 7.0 ± 1.2%; p = 0.025) at 1 month. Our animal pilot study suggests that AS-OCTA was able to detect limbal vessel disruption from various severities of acute chemical insult, and in the future, could potentially serve as an adjunct in providing objective grading of acute ocular chemical injury once validated in a clinical trial.
format	article
author	Kai Yuan Tey Jinyuan Gan Valencia Foo Bingyao Tan Meng Yuan Ke Leopold Schmetterer Jodhbir S. Mehta Marcus Ang
author_facet	Kai Yuan Tey Jinyuan Gan Valencia Foo Bingyao Tan Meng Yuan Ke Leopold Schmetterer Jodhbir S. Mehta Marcus Ang
author_sort	Kai Yuan Tey
title	Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study
title_short	Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study
title_full	Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study
title_fullStr	Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study
title_full_unstemmed	Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study
title_sort	role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/977eabf154cd4eacab32359c1ef28aa3
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Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study

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