Faster decay of neutralizing antibodies in never infected than previously infected healthcare workers three months after the second BNT162b2 mRNA COVID-19 vaccine dose

Objectives: This study aimed to describe the longitudinal evolution of neutralizing antibody titres (NtAb) in three different cohorts of healthcare workers (HCWs), including vaccinated HCWs with and without a previous SARS-CoV-2 infection and previously infected unvaccinated HCWs. COVID-19 was mild...

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Autores principales:	Ilaria Vicenti, Monica Basso, Francesca Gatti, Renzo Scaggiante, Adele Boccuto, Daniela Zago, Eliana Modolo, Filippo Dragoni, Saverio Giuseppe Parisi, Maurizio Zazzi
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Healthcare workers BNT162b2 mRNA COVID-19 vaccine Neutralizing antibodies COVID-19 Mild disease Asymptomatic Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/977f1397ef8f44b082acf510e02bdd60
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spelling	oai:doaj.org-article:977f1397ef8f44b082acf510e02bdd602021-11-30T04:14:00ZFaster decay of neutralizing antibodies in never infected than previously infected healthcare workers three months after the second BNT162b2 mRNA COVID-19 vaccine dose1201-971210.1016/j.ijid.2021.08.052https://doaj.org/article/977f1397ef8f44b082acf510e02bdd602021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221006834https://doaj.org/toc/1201-9712Objectives: This study aimed to describe the longitudinal evolution of neutralizing antibody titres (NtAb) in three different cohorts of healthcare workers (HCWs), including vaccinated HCWs with and without a previous SARS-CoV-2 infection and previously infected unvaccinated HCWs. COVID-19 was mild or asymptomatic in those experiencing infection. Methods: NtAb was tested before BNT162b2 mRNA COVID-19 vaccine (V0), 20±2 days after the first dose (V1_20), 20±3 days (V2_20) and 90±2 days (V2_90) after the second dose in vaccinated HCWs and after about 2 months (N_60), 10 months (N_300) and 13 months (N_390) from natural infection in unvaccinated HCWs. NtAb were measured by authentic virus neutralization with a SARS-CoV-2 B.1 isolate circulating in Italy at HCW enrolment. Results: Sixty-two HCWs were enrolled. NtAb were comparable in infected HCWs with no or mild disease at all the study points. NtAb of uninfected HCWs were significantly lower with respect to those of previously infected HCWs at V1_20, V2_20 and V2_90. The median NtAb fold decrease from V2_20 to V2_90 was higher in the uninfected HCWs with respect to those with mild infection (6.26 vs 2.58, p=0.03) and to asymptomatic HCWs (6.26 vs 3.67, p=0.022). The median Nabt at N_390 was significantly lower than at N_60 (p=0.007). Conclusions: In uninfected HCWs completing the two-dose vaccine schedule, a third mRNA vaccine dose is a reasonable option to counteract the substantial NtAb decline occurring at a significantly higher rate compared with previously infected, vaccinated HCWs. Although low, Nabt were still at a detectable level after 13 months in two-thirds of previously infected and unvaccinated HCWs.Ilaria VicentiMonica BassoFrancesca GattiRenzo ScaggianteAdele BoccutoDaniela ZagoEliana ModoloFilippo DragoniSaverio Giuseppe ParisiMaurizio ZazziElsevierarticleHealthcare workersBNT162b2 mRNA COVID-19 vaccineNeutralizing antibodiesCOVID-19Mild diseaseAsymptomaticInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 40-44 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Healthcare workers BNT162b2 mRNA COVID-19 vaccine Neutralizing antibodies COVID-19 Mild disease Asymptomatic Infectious and parasitic diseases RC109-216
spellingShingle	Healthcare workers BNT162b2 mRNA COVID-19 vaccine Neutralizing antibodies COVID-19 Mild disease Asymptomatic Infectious and parasitic diseases RC109-216 Ilaria Vicenti Monica Basso Francesca Gatti Renzo Scaggiante Adele Boccuto Daniela Zago Eliana Modolo Filippo Dragoni Saverio Giuseppe Parisi Maurizio Zazzi Faster decay of neutralizing antibodies in never infected than previously infected healthcare workers three months after the second BNT162b2 mRNA COVID-19 vaccine dose
description	Objectives: This study aimed to describe the longitudinal evolution of neutralizing antibody titres (NtAb) in three different cohorts of healthcare workers (HCWs), including vaccinated HCWs with and without a previous SARS-CoV-2 infection and previously infected unvaccinated HCWs. COVID-19 was mild or asymptomatic in those experiencing infection. Methods: NtAb was tested before BNT162b2 mRNA COVID-19 vaccine (V0), 20±2 days after the first dose (V1_20), 20±3 days (V2_20) and 90±2 days (V2_90) after the second dose in vaccinated HCWs and after about 2 months (N_60), 10 months (N_300) and 13 months (N_390) from natural infection in unvaccinated HCWs. NtAb were measured by authentic virus neutralization with a SARS-CoV-2 B.1 isolate circulating in Italy at HCW enrolment. Results: Sixty-two HCWs were enrolled. NtAb were comparable in infected HCWs with no or mild disease at all the study points. NtAb of uninfected HCWs were significantly lower with respect to those of previously infected HCWs at V1_20, V2_20 and V2_90. The median NtAb fold decrease from V2_20 to V2_90 was higher in the uninfected HCWs with respect to those with mild infection (6.26 vs 2.58, p=0.03) and to asymptomatic HCWs (6.26 vs 3.67, p=0.022). The median Nabt at N_390 was significantly lower than at N_60 (p=0.007). Conclusions: In uninfected HCWs completing the two-dose vaccine schedule, a third mRNA vaccine dose is a reasonable option to counteract the substantial NtAb decline occurring at a significantly higher rate compared with previously infected, vaccinated HCWs. Although low, Nabt were still at a detectable level after 13 months in two-thirds of previously infected and unvaccinated HCWs.
format	article
author	Ilaria Vicenti Monica Basso Francesca Gatti Renzo Scaggiante Adele Boccuto Daniela Zago Eliana Modolo Filippo Dragoni Saverio Giuseppe Parisi Maurizio Zazzi
author_facet	Ilaria Vicenti Monica Basso Francesca Gatti Renzo Scaggiante Adele Boccuto Daniela Zago Eliana Modolo Filippo Dragoni Saverio Giuseppe Parisi Maurizio Zazzi
author_sort	Ilaria Vicenti
title	Faster decay of neutralizing antibodies in never infected than previously infected healthcare workers three months after the second BNT162b2 mRNA COVID-19 vaccine dose
title_short	Faster decay of neutralizing antibodies in never infected than previously infected healthcare workers three months after the second BNT162b2 mRNA COVID-19 vaccine dose
title_full	Faster decay of neutralizing antibodies in never infected than previously infected healthcare workers three months after the second BNT162b2 mRNA COVID-19 vaccine dose
title_fullStr	Faster decay of neutralizing antibodies in never infected than previously infected healthcare workers three months after the second BNT162b2 mRNA COVID-19 vaccine dose
title_full_unstemmed	Faster decay of neutralizing antibodies in never infected than previously infected healthcare workers three months after the second BNT162b2 mRNA COVID-19 vaccine dose
title_sort	faster decay of neutralizing antibodies in never infected than previously infected healthcare workers three months after the second bnt162b2 mrna covid-19 vaccine dose
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/977f1397ef8f44b082acf510e02bdd60
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Faster decay of neutralizing antibodies in never infected than previously infected healthcare workers three months after the second BNT162b2 mRNA COVID-19 vaccine dose

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