Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe2O4/Zn-Fe Mixed Metal Oxides Nanocomposite

Ahmed AG El-Shahawy, 1 SA Abdel Moaty, 2 AH Zaki, 1 Nada A Mohamed, 2 Yasser GadelHak, 1 RK Mahmoud, 2 AA Farghali 1 1Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, Egypt; 2Chemistry Department, Facult...

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Autores principales:	El-Shahawy AAG, Abdel Moaty SA, Zaki AH, Mohamed NA, GadelHak Y, Mahmoud RK, Farghali AA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cytotoxicity inorganic nanomaterials prostate cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/977f46385be5442dac1668ea91bd3069
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spelling	oai:doaj.org-article:977f46385be5442dac1668ea91bd30692021-12-02T00:43:45ZProstate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe2O4/Zn-Fe Mixed Metal Oxides Nanocomposite1178-2013https://doaj.org/article/977f46385be5442dac1668ea91bd30692020-01-01T00:00:00Zhttps://www.dovepress.com/prostate-cancer-cellular-uptake-of-ternary-titanate-nanotubescufe2o4zn-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ahmed AG El-Shahawy, 1 SA Abdel Moaty, 2 AH Zaki, 1 Nada A Mohamed, 2 Yasser GadelHak, 1 RK Mahmoud, 2 AA Farghali 1 1Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, Egypt; 2Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, EgyptCorrespondence: Ahmed AG El-Shahawy Tel +201226798209Email Ahmedelshahawy382@yahoo.comBackground: Certainly, there is a demand for stronger recognition of how nanoparticles can move through the cell membrane. Prostate cancer is one of the forcing sources of cancer-relevant deaths among men.Aim of the Work: The current research studied the power of prostate cancer cells to uptake a ternary nanocomposite TNT/CuFe 2O 4/Zn-Fe mixed metal oxides (MMO).Methodology: The nanocomposite was synthesized by a chemical method and characterized by a High-resolution transmission electron microscope, Field emission scanning electron microscope, X-ray diffraction, Fourier transmission infra-red, X-ray photoelectron spectroscopy, dynamic light scattering. Besides, it was implemented as an inorganic anticancer agent versus Prostate cancer PC-3 cells.Results: The results revealed cellular uptake validity, cell viability reduction, ultra-structures alterations, morphological changes and membrane damage of PC-3 cells.Conclusion: The prepared ternary nanocomposite was highly uptake by PC-3 cells and possessed cytotoxicity that was dose and time-dependent. To conclude, the study offered the potential of the investigated ternary nanocomposite as a promising prostate anticancer agent.Keywords: cytotoxicity, inorganic nanomaterials, prostate cancerEl-Shahawy AAGAbdel Moaty SAZaki AHMohamed NAGadelHak YMahmoud RKFarghali AADove Medical Pressarticlecytotoxicityinorganic nanomaterialsprostate cancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 619-631 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytotoxicity inorganic nanomaterials prostate cancer Medicine (General) R5-920
spellingShingle	cytotoxicity inorganic nanomaterials prostate cancer Medicine (General) R5-920 El-Shahawy AAG Abdel Moaty SA Zaki AH Mohamed NA GadelHak Y Mahmoud RK Farghali AA Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe2O4/Zn-Fe Mixed Metal Oxides Nanocomposite
description	Ahmed AG El-Shahawy, 1 SA Abdel Moaty, 2 AH Zaki, 1 Nada A Mohamed, 2 Yasser GadelHak, 1 RK Mahmoud, 2 AA Farghali 1 1Materials Science and Nanotechnology Department, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef, Egypt; 2Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, EgyptCorrespondence: Ahmed AG El-Shahawy Tel +201226798209Email Ahmedelshahawy382@yahoo.comBackground: Certainly, there is a demand for stronger recognition of how nanoparticles can move through the cell membrane. Prostate cancer is one of the forcing sources of cancer-relevant deaths among men.Aim of the Work: The current research studied the power of prostate cancer cells to uptake a ternary nanocomposite TNT/CuFe 2O 4/Zn-Fe mixed metal oxides (MMO).Methodology: The nanocomposite was synthesized by a chemical method and characterized by a High-resolution transmission electron microscope, Field emission scanning electron microscope, X-ray diffraction, Fourier transmission infra-red, X-ray photoelectron spectroscopy, dynamic light scattering. Besides, it was implemented as an inorganic anticancer agent versus Prostate cancer PC-3 cells.Results: The results revealed cellular uptake validity, cell viability reduction, ultra-structures alterations, morphological changes and membrane damage of PC-3 cells.Conclusion: The prepared ternary nanocomposite was highly uptake by PC-3 cells and possessed cytotoxicity that was dose and time-dependent. To conclude, the study offered the potential of the investigated ternary nanocomposite as a promising prostate anticancer agent.Keywords: cytotoxicity, inorganic nanomaterials, prostate cancer
format	article
author	El-Shahawy AAG Abdel Moaty SA Zaki AH Mohamed NA GadelHak Y Mahmoud RK Farghali AA
author_facet	El-Shahawy AAG Abdel Moaty SA Zaki AH Mohamed NA GadelHak Y Mahmoud RK Farghali AA
author_sort	El-Shahawy AAG
title	Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe2O4/Zn-Fe Mixed Metal Oxides Nanocomposite
title_short	Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe2O4/Zn-Fe Mixed Metal Oxides Nanocomposite
title_full	Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe2O4/Zn-Fe Mixed Metal Oxides Nanocomposite
title_fullStr	Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe2O4/Zn-Fe Mixed Metal Oxides Nanocomposite
title_full_unstemmed	Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe2O4/Zn-Fe Mixed Metal Oxides Nanocomposite
title_sort	prostate cancer cellular uptake of ternary titanate nanotubes/cufe2o4/zn-fe mixed metal oxides nanocomposite
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/977f46385be5442dac1668ea91bd3069
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Prostate Cancer Cellular Uptake of Ternary Titanate Nanotubes/CuFe2O4/Zn-Fe Mixed Metal Oxides Nanocomposite

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