Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells

Innate T cells such as iNKT, MAIT and γδ T cells all develop in the thymus, but their differentiation paths are still unclear. Here, the authors show, using single-cell RNA sequencing, that all three cell types develop via shared and branched differentiation paths that are corroborated by additional...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Minji Lee, Eunmin Lee, Seong Kyu Han, Yoon Ha Choi, Dong-il Kwon, Hyobeen Choi, Kwanghwan Lee, Eun Seo Park, Min-Seok Rha, Dong Jin Joo, Eui-Cheol Shin, Sanguk Kim, Jong Kyoung Kim, You Jeong Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97819ac4bd8d4a1ea6cbc6a606eaa7dd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:97819ac4bd8d4a1ea6cbc6a606eaa7dd
record_format	dspace
spelling	oai:doaj.org-article:97819ac4bd8d4a1ea6cbc6a606eaa7dd2021-12-02T19:09:31ZSingle-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells10.1038/s41467-020-18155-82041-1723https://doaj.org/article/97819ac4bd8d4a1ea6cbc6a606eaa7dd2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18155-8https://doaj.org/toc/2041-1723Innate T cells such as iNKT, MAIT and γδ T cells all develop in the thymus, but their differentiation paths are still unclear. Here, the authors show, using single-cell RNA sequencing, that all three cell types develop via shared and branched differentiation paths that are corroborated by additional results from gene-deficient mice and human liver T cells.Minji LeeEunmin LeeSeong Kyu HanYoon Ha ChoiDong-il KwonHyobeen ChoiKwanghwan LeeEun Seo ParkMin-Seok RhaDong Jin JooEui-Cheol ShinSanguk KimJong Kyoung KimYou Jeong LeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minji Lee Eunmin Lee Seong Kyu Han Yoon Ha Choi Dong-il Kwon Hyobeen Choi Kwanghwan Lee Eun Seo Park Min-Seok Rha Dong Jin Joo Eui-Cheol Shin Sanguk Kim Jong Kyoung Kim You Jeong Lee Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells
description	Innate T cells such as iNKT, MAIT and γδ T cells all develop in the thymus, but their differentiation paths are still unclear. Here, the authors show, using single-cell RNA sequencing, that all three cell types develop via shared and branched differentiation paths that are corroborated by additional results from gene-deficient mice and human liver T cells.
format	article
author	Minji Lee Eunmin Lee Seong Kyu Han Yoon Ha Choi Dong-il Kwon Hyobeen Choi Kwanghwan Lee Eun Seo Park Min-Seok Rha Dong Jin Joo Eui-Cheol Shin Sanguk Kim Jong Kyoung Kim You Jeong Lee
author_facet	Minji Lee Eunmin Lee Seong Kyu Han Yoon Ha Choi Dong-il Kwon Hyobeen Choi Kwanghwan Lee Eun Seo Park Min-Seok Rha Dong Jin Joo Eui-Cheol Shin Sanguk Kim Jong Kyoung Kim You Jeong Lee
author_sort	Minji Lee
title	Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells
title_short	Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells
title_full	Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells
title_fullStr	Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells
title_full_unstemmed	Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells
title_sort	single-cell rna sequencing identifies shared differentiation paths of mouse thymic innate t cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/97819ac4bd8d4a1ea6cbc6a606eaa7dd
work_keys_str_mv	AT minjilee singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT eunminlee singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT seongkyuhan singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT yoonhachoi singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT dongilkwon singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT hyobeenchoi singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT kwanghwanlee singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT eunseopark singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT minseokrha singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT dongjinjoo singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT euicheolshin singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT sangukkim singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT jongkyoungkim singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells AT youjeonglee singlecellrnasequencingidentifiesshareddifferentiationpathsofmousethymicinnatetcells
_version_	1718377103874850816

Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells

Ejemplares similares