Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury

Chronic inflammation is a feature of age-related regenerative decline in skeletal muscles, but how it directly affects resident muscle stem cell fate and function is unclear. Here, the authors show that Ccr2 signaling in muscle stem cell derived progenitors represses terminal myogenic differentiatio...

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Autores principales:	Roméo S. Blanc, Jacob G. Kallenbach, John F. Bachman, Amanda Mitchell, Nicole D. Paris, Joe V. Chakkalakal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97820830ea5346b191e5ed3b4140df98
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spelling	oai:doaj.org-article:97820830ea5346b191e5ed3b4140df982021-12-02T17:08:30ZInhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury10.1038/s41467-020-17620-82041-1723https://doaj.org/article/97820830ea5346b191e5ed3b4140df982020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17620-8https://doaj.org/toc/2041-1723Chronic inflammation is a feature of age-related regenerative decline in skeletal muscles, but how it directly affects resident muscle stem cell fate and function is unclear. Here, the authors show that Ccr2 signaling in muscle stem cell derived progenitors represses terminal myogenic differentiation, and that targeting Ccr2 on aged myogenic progenitors rejuvenates aged skeletal muscle healing and function.Roméo S. BlancJacob G. KallenbachJohn F. BachmanAmanda MitchellNicole D. ParisJoe V. ChakkalakalNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roméo S. Blanc Jacob G. Kallenbach John F. Bachman Amanda Mitchell Nicole D. Paris Joe V. Chakkalakal Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury
description	Chronic inflammation is a feature of age-related regenerative decline in skeletal muscles, but how it directly affects resident muscle stem cell fate and function is unclear. Here, the authors show that Ccr2 signaling in muscle stem cell derived progenitors represses terminal myogenic differentiation, and that targeting Ccr2 on aged myogenic progenitors rejuvenates aged skeletal muscle healing and function.
format	article
author	Roméo S. Blanc Jacob G. Kallenbach John F. Bachman Amanda Mitchell Nicole D. Paris Joe V. Chakkalakal
author_facet	Roméo S. Blanc Jacob G. Kallenbach John F. Bachman Amanda Mitchell Nicole D. Paris Joe V. Chakkalakal
author_sort	Roméo S. Blanc
title	Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury
title_short	Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury
title_full	Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury
title_fullStr	Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury
title_full_unstemmed	Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury
title_sort	inhibition of inflammatory ccr2 signaling promotes aged muscle regeneration and strength recovery after injury
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/97820830ea5346b191e5ed3b4140df98
work_keys_str_mv	AT romeosblanc inhibitionofinflammatoryccr2signalingpromotesagedmuscleregenerationandstrengthrecoveryafterinjury AT jacobgkallenbach inhibitionofinflammatoryccr2signalingpromotesagedmuscleregenerationandstrengthrecoveryafterinjury AT johnfbachman inhibitionofinflammatoryccr2signalingpromotesagedmuscleregenerationandstrengthrecoveryafterinjury AT amandamitchell inhibitionofinflammatoryccr2signalingpromotesagedmuscleregenerationandstrengthrecoveryafterinjury AT nicoledparis inhibitionofinflammatoryccr2signalingpromotesagedmuscleregenerationandstrengthrecoveryafterinjury AT joevchakkalakal inhibitionofinflammatoryccr2signalingpromotesagedmuscleregenerationandstrengthrecoveryafterinjury
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Inhibition of inflammatory CCR2 signaling promotes aged muscle regeneration and strength recovery after injury

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