No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis

Abstract Cognitive impairment is an important predictor of disability in schizophrenia. Dopamine neurotransmission in cortical brain regions has been suggested to be of importance for higher-order cognitive processes. The aim of this study was to examine the relationship between extrastriatal dopami...

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Autores principales:	Maria Lee, Helena Fatouros-Bergman, Pontus Plavén-Sigray, Pauliina Ikonen Victorsson, Carl M. Sellgren, Sophie Erhardt, Lena Flyckt, Lars Farde, Simon Cervenka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/97839361cd674a3f8ef26c888c06933c
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spelling	oai:doaj.org-article:97839361cd674a3f8ef26c888c06933c2021-12-02T15:14:36ZNo association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis10.1038/s41537-021-00176-x2334-265Xhttps://doaj.org/article/97839361cd674a3f8ef26c888c06933c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00176-xhttps://doaj.org/toc/2334-265XAbstract Cognitive impairment is an important predictor of disability in schizophrenia. Dopamine neurotransmission in cortical brain regions has been suggested to be of importance for higher-order cognitive processes. The aim of this study was to examine the relationship between extrastriatal dopamine D2-R availability and cognitive function, using positron emission tomography and the high-affinity D2-R radioligand [11C]FLB 457, in an antipsychotic-naive sample of 18 first-episode psychosis patients and 16 control subjects. We observed no significant associations between D2-R binding in the dorsolateral prefrontal cortex or hippocampus (β = 0.013–0.074, partial r = −0.037–0.273, p = 0.131–0.841). Instead, using Bayesian statistics, we found moderate support for the null hypothesis of no relationship (BFH0:H1 = 3.3–8.2). Theoretically, our findings may suggest a lack of detrimental effects of D2-R antagonist drugs on cognition in schizophrenia patients, in line with clinical observations.Maria LeeHelena Fatouros-BergmanPontus Plavén-SigrayPauliina Ikonen VictorssonCarl M. SellgrenSophie ErhardtLena FlycktLars FardeSimon CervenkaNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Maria Lee Helena Fatouros-Bergman Pontus Plavén-Sigray Pauliina Ikonen Victorsson Carl M. Sellgren Sophie Erhardt Lena Flyckt Lars Farde Simon Cervenka No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis
description	Abstract Cognitive impairment is an important predictor of disability in schizophrenia. Dopamine neurotransmission in cortical brain regions has been suggested to be of importance for higher-order cognitive processes. The aim of this study was to examine the relationship between extrastriatal dopamine D2-R availability and cognitive function, using positron emission tomography and the high-affinity D2-R radioligand [11C]FLB 457, in an antipsychotic-naive sample of 18 first-episode psychosis patients and 16 control subjects. We observed no significant associations between D2-R binding in the dorsolateral prefrontal cortex or hippocampus (β = 0.013–0.074, partial r = −0.037–0.273, p = 0.131–0.841). Instead, using Bayesian statistics, we found moderate support for the null hypothesis of no relationship (BFH0:H1 = 3.3–8.2). Theoretically, our findings may suggest a lack of detrimental effects of D2-R antagonist drugs on cognition in schizophrenia patients, in line with clinical observations.
format	article
author	Maria Lee Helena Fatouros-Bergman Pontus Plavén-Sigray Pauliina Ikonen Victorsson Carl M. Sellgren Sophie Erhardt Lena Flyckt Lars Farde Simon Cervenka
author_facet	Maria Lee Helena Fatouros-Bergman Pontus Plavén-Sigray Pauliina Ikonen Victorsson Carl M. Sellgren Sophie Erhardt Lena Flyckt Lars Farde Simon Cervenka
author_sort	Maria Lee
title	No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis
title_short	No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis
title_full	No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis
title_fullStr	No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis
title_full_unstemmed	No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis
title_sort	no association between cortical dopamine d2 receptor availability and cognition in antipsychotic-naive first-episode psychosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97839361cd674a3f8ef26c888c06933c
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No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis

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