Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem

Historically, the following two methods were used to treat gestational diabetes mellitus: non-medical life-style interventions (diet and increased physical activity) and insulin treatment when other interventions were not effective. The possibility of alternative types of treatment such as oral anti...

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Autores principales:	Anna I. Sazonova, Roza M. Esayan, Oksana I. Kolegaeva, Zhanna R. Gardanova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2016
Materias:	metformin gestational diabetes mellitus pregnancy Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/978741f742c541f2bcb9368718ac0bf5
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spelling	oai:doaj.org-article:978741f742c541f2bcb9368718ac0bf52021-11-14T09:00:20ZEfficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem2072-03512072-037810.14341/DM2004126-29https://doaj.org/article/978741f742c541f2bcb9368718ac0bf52016-05-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7797https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Historically, the following two methods were used to treat gestational diabetes mellitus: non-medical life-style interventions (diet and increased physical activity) and insulin treatment when other interventions were not effective. The possibility of alternative types of treatment such as oral anti-diabetic drugs has been the source of debate in recent years. Metformin is an oral anti-diabetic drug that reduces insulin resistance, which is common during gestation and is considered one of the main pathways of glucose metabolism alteration during pregnancy. The main concern is that metformin can cross the placenta and is found unchanged in foetal blood. This is the reason why oral anti-diabetic drugs are contraindicated during pregnancy in many countries, including Russia (according to the 2012 Russian recommendations for gestational diabetes treatment). In recent years, many studies investigating the safety and efficacy of metformin for maternal and foetal health have been published. We will review recent randomized clinical trials and discuss new international clinical recommendations (FIGO, 2015) and new opportunities for gestational diabetes mellitus treatment.Anna I. SazonovaRoza M. EsayanOksana I. KolegaevaZhanna R. GardanovaEndocrinology Research Centrearticlemetformingestational diabetes mellituspregnancyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 19, Iss 2, Pp 164-170 (2016)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	metformin gestational diabetes mellitus pregnancy Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	metformin gestational diabetes mellitus pregnancy Nutritional diseases. Deficiency diseases RC620-627 Anna I. Sazonova Roza M. Esayan Oksana I. Kolegaeva Zhanna R. Gardanova Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem
description	Historically, the following two methods were used to treat gestational diabetes mellitus: non-medical life-style interventions (diet and increased physical activity) and insulin treatment when other interventions were not effective. The possibility of alternative types of treatment such as oral anti-diabetic drugs has been the source of debate in recent years. Metformin is an oral anti-diabetic drug that reduces insulin resistance, which is common during gestation and is considered one of the main pathways of glucose metabolism alteration during pregnancy. The main concern is that metformin can cross the placenta and is found unchanged in foetal blood. This is the reason why oral anti-diabetic drugs are contraindicated during pregnancy in many countries, including Russia (according to the 2012 Russian recommendations for gestational diabetes treatment). In recent years, many studies investigating the safety and efficacy of metformin for maternal and foetal health have been published. We will review recent randomized clinical trials and discuss new international clinical recommendations (FIGO, 2015) and new opportunities for gestational diabetes mellitus treatment.
format	article
author	Anna I. Sazonova Roza M. Esayan Oksana I. Kolegaeva Zhanna R. Gardanova
author_facet	Anna I. Sazonova Roza M. Esayan Oksana I. Kolegaeva Zhanna R. Gardanova
author_sort	Anna I. Sazonova
title	Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem
title_short	Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem
title_full	Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem
title_fullStr	Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem
title_full_unstemmed	Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem
title_sort	efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem
publisher	Endocrinology Research Centre
publishDate	2016
url	https://doaj.org/article/978741f742c541f2bcb9368718ac0bf5
work_keys_str_mv	AT annaisazonova efficacyandsafetyofmetforminforthetreatmentofgestationaldiabetesanewapproachtotheproblem AT rozamesayan efficacyandsafetyofmetforminforthetreatmentofgestationaldiabetesanewapproachtotheproblem AT oksanaikolegaeva efficacyandsafetyofmetforminforthetreatmentofgestationaldiabetesanewapproachtotheproblem AT zhannargardanova efficacyandsafetyofmetforminforthetreatmentofgestationaldiabetesanewapproachtotheproblem
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Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem

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