Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post-translational levels which is relevant to colon can...

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Autores principales:	Boning Niu, Jie Liu, Ben Lv, Jiacheng Lin, Xin Li, Chunxiao Wu, Xiaohua Jiang, Zhiping Zeng, Xiao-kun Zhang, Hu Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/978880fb5aa84de2b50472280ae92ec3
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spelling	oai:doaj.org-article:978880fb5aa84de2b50472280ae92ec32021-12-02T17:15:23ZInterplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis10.1038/s41467-021-23048-52041-1723https://doaj.org/article/978880fb5aa84de2b50472280ae92ec32021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23048-5https://doaj.org/toc/2041-1723Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post-translational levels which is relevant to colon cancer stemness, metastasis and resistance to oxaliplatin.Boning NiuJie LiuBen LvJiacheng LinXin LiChunxiao WuXiaohua JiangZhiping ZengXiao-kun ZhangHu ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Boning Niu Jie Liu Ben Lv Jiacheng Lin Xin Li Chunxiao Wu Xiaohua Jiang Zhiping Zeng Xiao-kun Zhang Hu Zhou Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis
description	Inhibitor of Differentiation 1 (ID1) is an oncogene for colorectal cancer. Here, the authors show a complex interplay between nuclear receptor Nur77 and Transforming Growth Factor-β (TGFβ) to regulate ID1 expression at both transcriptional and post-translational levels which is relevant to colon cancer stemness, metastasis and resistance to oxaliplatin.
format	article
author	Boning Niu Jie Liu Ben Lv Jiacheng Lin Xin Li Chunxiao Wu Xiaohua Jiang Zhiping Zeng Xiao-kun Zhang Hu Zhou
author_facet	Boning Niu Jie Liu Ben Lv Jiacheng Lin Xin Li Chunxiao Wu Xiaohua Jiang Zhiping Zeng Xiao-kun Zhang Hu Zhou
author_sort	Boning Niu
title	Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis
title_short	Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis
title_full	Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis
title_fullStr	Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis
title_full_unstemmed	Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis
title_sort	interplay between transforming growth factor-β and nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/978880fb5aa84de2b50472280ae92ec3
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Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

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