Suppression of Electrographic Seizures Is Associated with Amelioration of QTc Interval Prolongation in Patients with Traumatic Brain Injury

Introduction: Disorders in electroencephalography (EEG) are commonly noted in patients with traumatic brain injury (TBI) and may be associated with electrocardiographic disturbances. Electrographic seizures (ESz) are the most common features in these patients. This study aimed to explore the relatio...

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Autores principales:	Wojciech Dabrowski, Dorota Siwicka-Gieroba, Todd T. Schlegel, Chiara Robba, Sami Zaid, Magdalena Bielacz, Andrzej Jaroszyński, Rafael Badenes
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	seizure traumatic brain injury QTc interval spatial QTS-T angle brain–heart interaction Medicine R
Acceso en línea:	https://doaj.org/article/978d085851ea4bccb650973c4f8f7bc7
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spelling	oai:doaj.org-article:978d085851ea4bccb650973c4f8f7bc72021-11-25T18:02:13ZSuppression of Electrographic Seizures Is Associated with Amelioration of QTc Interval Prolongation in Patients with Traumatic Brain Injury10.3390/jcm102253742077-0383https://doaj.org/article/978d085851ea4bccb650973c4f8f7bc72021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5374https://doaj.org/toc/2077-0383Introduction: Disorders in electroencephalography (EEG) are commonly noted in patients with traumatic brain injury (TBI) and may be associated with electrocardiographic disturbances. Electrographic seizures (ESz) are the most common features in these patients. This study aimed to explore the relationship between ESz and possible changes in QTc interval and spatial QRS-T angle both during ESz and after ESz resolution. Methods: Adult patients with TBI were studied. Surface 12-lead ECGs were recorded using a Cardiax device during ESz events and 15 min after their effective suppression using barbiturate infusion. The ESz events were diagnosed using Masimo Root or bispectral index (BIS) devices. Results: Of the 348 patients considered for possible inclusion, ESz were noted in 72, with ECG being recorded in 21. Prolonged QTc was noted during ESz but significantly ameliorated after ESz suppression (540.19 ± 60.68 ms vs. 478.67 ± 38.52 ms, <i>p</i> < 0.001). The spatial QRS-T angle was comparable during ESz and after treatment. Regional cerebral oximetry increased following ESz suppression (from 58.4% ± 6.2 to 60.5% ± 4.2 (<i>p</i> < 0.01) and from 58.2% ± 7.2 to 60.8% ± 4.8 (<i>p</i> < 0.05) in the left and right hemispheres, respectively). Conclusion: QTc interval prolongation occurs during ESz events in TBI patients but both it and regional cerebral oximetry are improved after suppression of seizures.Wojciech DabrowskiDorota Siwicka-GierobaTodd T. SchlegelChiara RobbaSami ZaidMagdalena BielaczAndrzej JaroszyńskiRafael BadenesMDPI AGarticleseizuretraumatic brain injuryQTc intervalspatial QTS-T anglebrain–heart interactionMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5374, p 5374 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	seizure traumatic brain injury QTc interval spatial QTS-T angle brain–heart interaction Medicine R
spellingShingle	seizure traumatic brain injury QTc interval spatial QTS-T angle brain–heart interaction Medicine R Wojciech Dabrowski Dorota Siwicka-Gieroba Todd T. Schlegel Chiara Robba Sami Zaid Magdalena Bielacz Andrzej Jaroszyński Rafael Badenes Suppression of Electrographic Seizures Is Associated with Amelioration of QTc Interval Prolongation in Patients with Traumatic Brain Injury
description	Introduction: Disorders in electroencephalography (EEG) are commonly noted in patients with traumatic brain injury (TBI) and may be associated with electrocardiographic disturbances. Electrographic seizures (ESz) are the most common features in these patients. This study aimed to explore the relationship between ESz and possible changes in QTc interval and spatial QRS-T angle both during ESz and after ESz resolution. Methods: Adult patients with TBI were studied. Surface 12-lead ECGs were recorded using a Cardiax device during ESz events and 15 min after their effective suppression using barbiturate infusion. The ESz events were diagnosed using Masimo Root or bispectral index (BIS) devices. Results: Of the 348 patients considered for possible inclusion, ESz were noted in 72, with ECG being recorded in 21. Prolonged QTc was noted during ESz but significantly ameliorated after ESz suppression (540.19 ± 60.68 ms vs. 478.67 ± 38.52 ms, <i>p</i> < 0.001). The spatial QRS-T angle was comparable during ESz and after treatment. Regional cerebral oximetry increased following ESz suppression (from 58.4% ± 6.2 to 60.5% ± 4.2 (<i>p</i> < 0.01) and from 58.2% ± 7.2 to 60.8% ± 4.8 (<i>p</i> < 0.05) in the left and right hemispheres, respectively). Conclusion: QTc interval prolongation occurs during ESz events in TBI patients but both it and regional cerebral oximetry are improved after suppression of seizures.
format	article
author	Wojciech Dabrowski Dorota Siwicka-Gieroba Todd T. Schlegel Chiara Robba Sami Zaid Magdalena Bielacz Andrzej Jaroszyński Rafael Badenes
author_facet	Wojciech Dabrowski Dorota Siwicka-Gieroba Todd T. Schlegel Chiara Robba Sami Zaid Magdalena Bielacz Andrzej Jaroszyński Rafael Badenes
author_sort	Wojciech Dabrowski
title	Suppression of Electrographic Seizures Is Associated with Amelioration of QTc Interval Prolongation in Patients with Traumatic Brain Injury
title_short	Suppression of Electrographic Seizures Is Associated with Amelioration of QTc Interval Prolongation in Patients with Traumatic Brain Injury
title_full	Suppression of Electrographic Seizures Is Associated with Amelioration of QTc Interval Prolongation in Patients with Traumatic Brain Injury
title_fullStr	Suppression of Electrographic Seizures Is Associated with Amelioration of QTc Interval Prolongation in Patients with Traumatic Brain Injury
title_full_unstemmed	Suppression of Electrographic Seizures Is Associated with Amelioration of QTc Interval Prolongation in Patients with Traumatic Brain Injury
title_sort	suppression of electrographic seizures is associated with amelioration of qtc interval prolongation in patients with traumatic brain injury
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/978d085851ea4bccb650973c4f8f7bc7
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Suppression of Electrographic Seizures Is Associated with Amelioration of QTc Interval Prolongation in Patients with Traumatic Brain Injury

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