PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation

Yen et al use tissue-specific PP2A knockout mice to show that PP2A in LepR positive mesenchymal stem cells positively regulates endochondral ossification. They find that PP2A dephosphorylates Runx2 and BRD4, thereby playing a major role in positively and negatively regulating osteogenesis and adipog...

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Main Authors:	Yu-Ting Yen, May Chien, Pei-Yi Wu, Shih-Chieh Hung
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/978e00f7f57c44eb88f999b670dfc8e4
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spelling	oai:doaj.org-article:978e00f7f57c44eb88f999b670dfc8e42021-12-02T15:56:49ZPP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation10.1038/s42003-021-02175-12399-3642https://doaj.org/article/978e00f7f57c44eb88f999b670dfc8e42021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02175-1https://doaj.org/toc/2399-3642Yen et al use tissue-specific PP2A knockout mice to show that PP2A in LepR positive mesenchymal stem cells positively regulates endochondral ossification. They find that PP2A dephosphorylates Runx2 and BRD4, thereby playing a major role in positively and negatively regulating osteogenesis and adipogenesis, respectively.Yu-Ting YenMay ChienPei-Yi WuShih-Chieh HungNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Yu-Ting Yen May Chien Pei-Yi Wu Shih-Chieh Hung PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation
description	Yen et al use tissue-specific PP2A knockout mice to show that PP2A in LepR positive mesenchymal stem cells positively regulates endochondral ossification. They find that PP2A dephosphorylates Runx2 and BRD4, thereby playing a major role in positively and negatively regulating osteogenesis and adipogenesis, respectively.
format	article
author	Yu-Ting Yen May Chien Pei-Yi Wu Shih-Chieh Hung
author_facet	Yu-Ting Yen May Chien Pei-Yi Wu Shih-Chieh Hung
author_sort	Yu-Ting Yen
title	PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation
title_short	PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation
title_full	PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation
title_fullStr	PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation
title_full_unstemmed	PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation
title_sort	pp2a in lepr+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through runx2 dephosphorylation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/978e00f7f57c44eb88f999b670dfc8e4
work_keys_str_mv	AT yutingyen pp2ainleprmesenchymalstemcellscontributestoembryonicandpostnatalendochondralossificationthroughrunx2dephosphorylation AT maychien pp2ainleprmesenchymalstemcellscontributestoembryonicandpostnatalendochondralossificationthroughrunx2dephosphorylation AT peiyiwu pp2ainleprmesenchymalstemcellscontributestoembryonicandpostnatalendochondralossificationthroughrunx2dephosphorylation AT shihchiehhung pp2ainleprmesenchymalstemcellscontributestoembryonicandpostnatalendochondralossificationthroughrunx2dephosphorylation
_version_	1718385407186436096

PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation

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