The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition
Adenocarcinoma and squamous cell carcinoma are distinct subtypes of non-small cell lung cancer. Here, the authors show that increased glycolytic flux, via increased glucose transporter Glut1 expression, is a core metabolic feature of squamous cell carcinoma that renders it sensitive to glycolysis in...
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Nature Portfolio
2017
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oai:doaj.org-article:978e7e9cf1334033ac7b7717d15952492021-12-02T15:38:36ZThe distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition10.1038/ncomms155032041-1723https://doaj.org/article/978e7e9cf1334033ac7b7717d15952492017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15503https://doaj.org/toc/2041-1723Adenocarcinoma and squamous cell carcinoma are distinct subtypes of non-small cell lung cancer. Here, the authors show that increased glycolytic flux, via increased glucose transporter Glut1 expression, is a core metabolic feature of squamous cell carcinoma that renders it sensitive to glycolysis inhibition.Justin GoodwinMichael L. NeugentShin Yup LeeJoshua H. ChoeHyunsung ChoiDana M. R. JenkinsRobin J. RuthenborgMaddox W. RobinsonJi Yun JeongMasaki WakeHajime AbeNorihiko TakedaHiroko EndoMasahiro InoueZhenyu XuanHyuntae YooMin ChenJung-Mo AhnJohn D. MinnaKristi L. HelkePankaj K. SinghDavid B. ShackelfordJung-whan KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
| spellingShingle |
Science Q Justin Goodwin Michael L. Neugent Shin Yup Lee Joshua H. Choe Hyunsung Choi Dana M. R. Jenkins Robin J. Ruthenborg Maddox W. Robinson Ji Yun Jeong Masaki Wake Hajime Abe Norihiko Takeda Hiroko Endo Masahiro Inoue Zhenyu Xuan Hyuntae Yoo Min Chen Jung-Mo Ahn John D. Minna Kristi L. Helke Pankaj K. Singh David B. Shackelford Jung-whan Kim The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition |
| description |
Adenocarcinoma and squamous cell carcinoma are distinct subtypes of non-small cell lung cancer. Here, the authors show that increased glycolytic flux, via increased glucose transporter Glut1 expression, is a core metabolic feature of squamous cell carcinoma that renders it sensitive to glycolysis inhibition. |
| format |
article |
| author |
Justin Goodwin Michael L. Neugent Shin Yup Lee Joshua H. Choe Hyunsung Choi Dana M. R. Jenkins Robin J. Ruthenborg Maddox W. Robinson Ji Yun Jeong Masaki Wake Hajime Abe Norihiko Takeda Hiroko Endo Masahiro Inoue Zhenyu Xuan Hyuntae Yoo Min Chen Jung-Mo Ahn John D. Minna Kristi L. Helke Pankaj K. Singh David B. Shackelford Jung-whan Kim |
| author_facet |
Justin Goodwin Michael L. Neugent Shin Yup Lee Joshua H. Choe Hyunsung Choi Dana M. R. Jenkins Robin J. Ruthenborg Maddox W. Robinson Ji Yun Jeong Masaki Wake Hajime Abe Norihiko Takeda Hiroko Endo Masahiro Inoue Zhenyu Xuan Hyuntae Yoo Min Chen Jung-Mo Ahn John D. Minna Kristi L. Helke Pankaj K. Singh David B. Shackelford Jung-whan Kim |
| author_sort |
Justin Goodwin |
| title |
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition |
| title_short |
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition |
| title_full |
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition |
| title_fullStr |
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition |
| title_full_unstemmed |
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition |
| title_sort |
distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/978e7e9cf1334033ac7b7717d1595249 |
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