Capturing transient antibody conformations with DNA origami epitopes

Understanding antibody-antigen interactions is important to deepen the understanding of immunology. Here, the authors report on the application of DNA origami structures for the controlled presentation of antigens to study antibody binding behaviours at room temperature.

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Detalles Bibliográficos
Autores principales: Ping Zhang, Xiaoguo Liu, Pi Liu, Fei Wang, Hirotaka Ariyama, Toshio Ando, Jianping Lin, Lihua Wang, Jun Hu, Bin Li, Chunhai Fan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/9790c451ed904099bfb8bd0d6eb1ee6a
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Sumario:Understanding antibody-antigen interactions is important to deepen the understanding of immunology. Here, the authors report on the application of DNA origami structures for the controlled presentation of antigens to study antibody binding behaviours at room temperature.