LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis

Dynamic assembly and disassembly of primary cilia is critical for tissue development and homeostasis. Here the authors identify lysophosphatidic acid (LPA) as a physiological extracellular factor that initiates cilia disassembly through both YAP/TAZ mediated transcription and calcium/calmodulin medi...

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Autores principales:	Huai-Bin Hu, Zeng-Qing Song, Guang-Ping Song, Sen Li, Hai-Qing Tu, Min Wu, Yu-Cheng Zhang, Jin-Feng Yuan, Ting-Ting Li, Pei-Yao Li, Yu-Ling Xu, Xiao-Lin Shen, Qiu-Ying Han, Ai-Ling Li, Tao Zhou, Jerold Chun, Xue-Min Zhang, Hui-Yan Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97910613ea80435caa0acc64ffdc0c23
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spelling	oai:doaj.org-article:97910613ea80435caa0acc64ffdc0c232021-12-02T14:16:13ZLPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis10.1038/s41467-021-20986-y2041-1723https://doaj.org/article/97910613ea80435caa0acc64ffdc0c232021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20986-yhttps://doaj.org/toc/2041-1723Dynamic assembly and disassembly of primary cilia is critical for tissue development and homeostasis. Here the authors identify lysophosphatidic acid (LPA) as a physiological extracellular factor that initiates cilia disassembly through both YAP/TAZ mediated transcription and calcium/calmodulin mediated activation of Aurora A.Huai-Bin HuZeng-Qing SongGuang-Ping SongSen LiHai-Qing TuMin WuYu-Cheng ZhangJin-Feng YuanTing-Ting LiPei-Yao LiYu-Ling XuXiao-Lin ShenQiu-Ying HanAi-Ling LiTao ZhouJerold ChunXue-Min ZhangHui-Yan LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huai-Bin Hu Zeng-Qing Song Guang-Ping Song Sen Li Hai-Qing Tu Min Wu Yu-Cheng Zhang Jin-Feng Yuan Ting-Ting Li Pei-Yao Li Yu-Ling Xu Xiao-Lin Shen Qiu-Ying Han Ai-Ling Li Tao Zhou Jerold Chun Xue-Min Zhang Hui-Yan Li LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
description	Dynamic assembly and disassembly of primary cilia is critical for tissue development and homeostasis. Here the authors identify lysophosphatidic acid (LPA) as a physiological extracellular factor that initiates cilia disassembly through both YAP/TAZ mediated transcription and calcium/calmodulin mediated activation of Aurora A.
format	article
author	Huai-Bin Hu Zeng-Qing Song Guang-Ping Song Sen Li Hai-Qing Tu Min Wu Yu-Cheng Zhang Jin-Feng Yuan Ting-Ting Li Pei-Yao Li Yu-Ling Xu Xiao-Lin Shen Qiu-Ying Han Ai-Ling Li Tao Zhou Jerold Chun Xue-Min Zhang Hui-Yan Li
author_facet	Huai-Bin Hu Zeng-Qing Song Guang-Ping Song Sen Li Hai-Qing Tu Min Wu Yu-Cheng Zhang Jin-Feng Yuan Ting-Ting Li Pei-Yao Li Yu-Ling Xu Xiao-Lin Shen Qiu-Ying Han Ai-Ling Li Tao Zhou Jerold Chun Xue-Min Zhang Hui-Yan Li
author_sort	Huai-Bin Hu
title	LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
title_short	LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
title_full	LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
title_fullStr	LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
title_full_unstemmed	LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
title_sort	lpa signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97910613ea80435caa0acc64ffdc0c23
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LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis

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