Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health

Abstract Schizophrenia (SCZ) is a psychiatric disorder characterized by a wide range of positive, negative and cognitive symptoms, along with an increased risk of metabolic syndrome and cardiovascular disease that contribute to a 15–20-year reduced life expectancy. Autonomic dysfunction, in the form...

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Autores principales:	Nicolette Stogios, Alexander Gdanski, Philip Gerretsen, Araba F. Chintoh, Ariel Graff-Guerrero, Tarek K. Rajji, Gary Remington, Margaret K. Hahn, Sri Mahavir Agarwal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/97938c5b0ea542a3a8d6bd15b45983a3
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spelling	oai:doaj.org-article:97938c5b0ea542a3a8d6bd15b45983a32021-12-02T17:39:27ZAutonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health10.1038/s41537-021-00151-62334-265Xhttps://doaj.org/article/97938c5b0ea542a3a8d6bd15b45983a32021-04-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00151-6https://doaj.org/toc/2334-265XAbstract Schizophrenia (SCZ) is a psychiatric disorder characterized by a wide range of positive, negative and cognitive symptoms, along with an increased risk of metabolic syndrome and cardiovascular disease that contribute to a 15–20-year reduced life expectancy. Autonomic dysfunction, in the form of increased sympathetic activity and decreased parasympathetic activity, is postulated to be implicated in SCZ and its treatment. The aim of this narrative review is to view SCZ through an autonomic lens and synthesize the evidence relating autonomic dysfunction to different domains of SCZ. Using various methods of assessing autonomic activity, autonomic dysfunction was found to be associated with multiple aspects of SCZ pathophysiology, including symptom severity, cognitive impairment, and the development of cardiometabolic comorbidities, such as metabolic syndrome and high BMI. The strongest association of low heart rate variability was noted among patients on antipsychotic treatment with high-affinity muscarinic antagonism (i.e., clozapine, olanzapine and quetiapine). The review will also suggest ways in which studying autonomic dysfunction can help reduce morbidity and mortality associated with SCZ and its treatment.Nicolette StogiosAlexander GdanskiPhilip GerretsenAraba F. ChintohAriel Graff-GuerreroTarek K. RajjiGary RemingtonMargaret K. HahnSri Mahavir AgarwalNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Nicolette Stogios Alexander Gdanski Philip Gerretsen Araba F. Chintoh Ariel Graff-Guerrero Tarek K. Rajji Gary Remington Margaret K. Hahn Sri Mahavir Agarwal Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
description	Abstract Schizophrenia (SCZ) is a psychiatric disorder characterized by a wide range of positive, negative and cognitive symptoms, along with an increased risk of metabolic syndrome and cardiovascular disease that contribute to a 15–20-year reduced life expectancy. Autonomic dysfunction, in the form of increased sympathetic activity and decreased parasympathetic activity, is postulated to be implicated in SCZ and its treatment. The aim of this narrative review is to view SCZ through an autonomic lens and synthesize the evidence relating autonomic dysfunction to different domains of SCZ. Using various methods of assessing autonomic activity, autonomic dysfunction was found to be associated with multiple aspects of SCZ pathophysiology, including symptom severity, cognitive impairment, and the development of cardiometabolic comorbidities, such as metabolic syndrome and high BMI. The strongest association of low heart rate variability was noted among patients on antipsychotic treatment with high-affinity muscarinic antagonism (i.e., clozapine, olanzapine and quetiapine). The review will also suggest ways in which studying autonomic dysfunction can help reduce morbidity and mortality associated with SCZ and its treatment.
format	article
author	Nicolette Stogios Alexander Gdanski Philip Gerretsen Araba F. Chintoh Ariel Graff-Guerrero Tarek K. Rajji Gary Remington Margaret K. Hahn Sri Mahavir Agarwal
author_facet	Nicolette Stogios Alexander Gdanski Philip Gerretsen Araba F. Chintoh Ariel Graff-Guerrero Tarek K. Rajji Gary Remington Margaret K. Hahn Sri Mahavir Agarwal
author_sort	Nicolette Stogios
title	Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
title_short	Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
title_full	Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
title_fullStr	Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
title_full_unstemmed	Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
title_sort	autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97938c5b0ea542a3a8d6bd15b45983a3
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Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health

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