An Observational Study to Evaluate the Association between Intestinal Permeability, Leaky Gut Related Markers, and Metabolic Health in Healthy Adults

We explored whether metabolic health is linked to intestinal permeability, using a multi-sugar (MS) permeability test, and whether intestinal permeability is correlated with the leaky gut-related markers (LGM) zonulin, LBP, and sCD14. Metabolically healthy (<i>n</i> = 15) and unhealthy s...

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Autores principales:	Hiroyuki Hoshiko, Gertrude G. Zeinstra, Kaatje Lenaerts, Els Oosterink, Renata M. C. Ariens, Jurriaan J. Mes, Nicole J. W. de Wit
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	metabolic intestinal permeability multi-sugar leaky gut Medicine R
Acceso en línea:	https://doaj.org/article/97959887982047ebac406fc82fcf027e
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spelling	oai:doaj.org-article:97959887982047ebac406fc82fcf027e2021-11-25T17:46:38ZAn Observational Study to Evaluate the Association between Intestinal Permeability, Leaky Gut Related Markers, and Metabolic Health in Healthy Adults10.3390/healthcare91115832227-9032https://doaj.org/article/97959887982047ebac406fc82fcf027e2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9032/9/11/1583https://doaj.org/toc/2227-9032We explored whether metabolic health is linked to intestinal permeability, using a multi-sugar (MS) permeability test, and whether intestinal permeability is correlated with the leaky gut-related markers (LGM) zonulin, LBP, and sCD14. Metabolically healthy (<i>n</i> = 15) and unhealthy subjects (<i>n</i> = 15) were recruited based on waist circumference, fasting glucose, and high-density lipoprotein cholesterol levels. Participants underwent an MS permeability test that assessed site-specific permeabilities of the gastroduodenum and small and large intestines. The test was performed with/without an acetylsalicylic acid challenge to measure and correlate the gut permeability, LGM, and metabolic health. At baseline, metabolic health showed no correlation with gut permeability. Significant correlations were found between the metabolic health parameters and LGM. In the acetylsalicylic acid challenged MS permeability test, low-density lipoprotein cholesterol was correlated with the sucralose/erythritol ratio, reflecting the whole intestinal permeability. Correlations between most metabolic health parameters and LGM during the acetylsalicylic acid challenge were less pronounced than at baseline. In both MS permeability tests, no significant correlations were found between LGM (plasma and serum) and gut permeability. Thus, correlations between LGM and metabolic health might not be linked with paracellular gut permeability. Transcellular translocation and/or lipoprotein-related transportation is a more likely mechanism underlying the association between LGM and metabolic health.Hiroyuki HoshikoGertrude G. ZeinstraKaatje LenaertsEls OosterinkRenata M. C. AriensJurriaan J. MesNicole J. W. de WitMDPI AGarticlemetabolicintestinal permeabilitymulti-sugarleaky gutMedicineRENHealthcare, Vol 9, Iss 1583, p 1583 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolic intestinal permeability multi-sugar leaky gut Medicine R
spellingShingle	metabolic intestinal permeability multi-sugar leaky gut Medicine R Hiroyuki Hoshiko Gertrude G. Zeinstra Kaatje Lenaerts Els Oosterink Renata M. C. Ariens Jurriaan J. Mes Nicole J. W. de Wit An Observational Study to Evaluate the Association between Intestinal Permeability, Leaky Gut Related Markers, and Metabolic Health in Healthy Adults
description	We explored whether metabolic health is linked to intestinal permeability, using a multi-sugar (MS) permeability test, and whether intestinal permeability is correlated with the leaky gut-related markers (LGM) zonulin, LBP, and sCD14. Metabolically healthy (<i>n</i> = 15) and unhealthy subjects (<i>n</i> = 15) were recruited based on waist circumference, fasting glucose, and high-density lipoprotein cholesterol levels. Participants underwent an MS permeability test that assessed site-specific permeabilities of the gastroduodenum and small and large intestines. The test was performed with/without an acetylsalicylic acid challenge to measure and correlate the gut permeability, LGM, and metabolic health. At baseline, metabolic health showed no correlation with gut permeability. Significant correlations were found between the metabolic health parameters and LGM. In the acetylsalicylic acid challenged MS permeability test, low-density lipoprotein cholesterol was correlated with the sucralose/erythritol ratio, reflecting the whole intestinal permeability. Correlations between most metabolic health parameters and LGM during the acetylsalicylic acid challenge were less pronounced than at baseline. In both MS permeability tests, no significant correlations were found between LGM (plasma and serum) and gut permeability. Thus, correlations between LGM and metabolic health might not be linked with paracellular gut permeability. Transcellular translocation and/or lipoprotein-related transportation is a more likely mechanism underlying the association between LGM and metabolic health.
format	article
author	Hiroyuki Hoshiko Gertrude G. Zeinstra Kaatje Lenaerts Els Oosterink Renata M. C. Ariens Jurriaan J. Mes Nicole J. W. de Wit
author_facet	Hiroyuki Hoshiko Gertrude G. Zeinstra Kaatje Lenaerts Els Oosterink Renata M. C. Ariens Jurriaan J. Mes Nicole J. W. de Wit
author_sort	Hiroyuki Hoshiko
title	An Observational Study to Evaluate the Association between Intestinal Permeability, Leaky Gut Related Markers, and Metabolic Health in Healthy Adults
title_short	An Observational Study to Evaluate the Association between Intestinal Permeability, Leaky Gut Related Markers, and Metabolic Health in Healthy Adults
title_full	An Observational Study to Evaluate the Association between Intestinal Permeability, Leaky Gut Related Markers, and Metabolic Health in Healthy Adults
title_fullStr	An Observational Study to Evaluate the Association between Intestinal Permeability, Leaky Gut Related Markers, and Metabolic Health in Healthy Adults
title_full_unstemmed	An Observational Study to Evaluate the Association between Intestinal Permeability, Leaky Gut Related Markers, and Metabolic Health in Healthy Adults
title_sort	observational study to evaluate the association between intestinal permeability, leaky gut related markers, and metabolic health in healthy adults
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/97959887982047ebac406fc82fcf027e
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An Observational Study to Evaluate the Association between Intestinal Permeability, Leaky Gut Related Markers, and Metabolic Health in Healthy Adults

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