Loss of TET2 and TET3 in regulatory T cells unleashes effector function

Loss of TET2 and TET3 in regulatory T cells unleashes effector function

Loss of TET proteins in immune cell populations is known to result in immunopathology. Here the authors show that deficiency of Tet2 and Tet3 proteins, specifically in the CD4+ FoxP3+ Treg lineage, results in a dominant pathology in which ex-Treg cells and bystander T cells gain aberrant effector fu...

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Autores principales: Xiaojing Yue, Chan-Wang J. Lio, Daniela Samaniego-Castruita, Xiang Li, Anjana Rao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/97966d4c69aa4caabfc8b722d4a2b325
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spelling oai:doaj.org-article:97966d4c69aa4caabfc8b722d4a2b3252021-12-02T14:35:44ZLoss of TET2 and TET3 in regulatory T cells unleashes effector function10.1038/s41467-019-09541-y2041-1723https://doaj.org/article/97966d4c69aa4caabfc8b722d4a2b3252019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09541-yhttps://doaj.org/toc/2041-1723Loss of TET proteins in immune cell populations is known to result in immunopathology. Here the authors show that deficiency of Tet2 and Tet3 proteins, specifically in the CD4+ FoxP3+ Treg lineage, results in a dominant pathology in which ex-Treg cells and bystander T cells gain aberrant effector function.Xiaojing YueChan-Wang J. LioDaniela Samaniego-CastruitaXiang LiAnjana RaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaojing Yue
Chan-Wang J. Lio
Daniela Samaniego-Castruita
Xiang Li
Anjana Rao
Loss of TET2 and TET3 in regulatory T cells unleashes effector function
description Loss of TET proteins in immune cell populations is known to result in immunopathology. Here the authors show that deficiency of Tet2 and Tet3 proteins, specifically in the CD4+ FoxP3+ Treg lineage, results in a dominant pathology in which ex-Treg cells and bystander T cells gain aberrant effector function.
format article
author Xiaojing Yue
Chan-Wang J. Lio
Daniela Samaniego-Castruita
Xiang Li
Anjana Rao
author_facet Xiaojing Yue
Chan-Wang J. Lio
Daniela Samaniego-Castruita
Xiang Li
Anjana Rao
author_sort Xiaojing Yue
title Loss of TET2 and TET3 in regulatory T cells unleashes effector function
title_short Loss of TET2 and TET3 in regulatory T cells unleashes effector function
title_full Loss of TET2 and TET3 in regulatory T cells unleashes effector function
title_fullStr Loss of TET2 and TET3 in regulatory T cells unleashes effector function
title_full_unstemmed Loss of TET2 and TET3 in regulatory T cells unleashes effector function
title_sort loss of tet2 and tet3 in regulatory t cells unleashes effector function
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/97966d4c69aa4caabfc8b722d4a2b325
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AT danielasamaniegocastruita lossoftet2andtet3inregulatorytcellsunleasheseffectorfunction
AT xiangli lossoftet2andtet3inregulatorytcellsunleasheseffectorfunction
AT anjanarao lossoftet2andtet3inregulatorytcellsunleasheseffectorfunction
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