Potential natural immunization against atherosclerosis in hibernating bears

Abstract Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are...

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Autores principales:	Shailesh Kumar Samal, Ole Fröbert, Jonas Kindberg, Peter Stenvinkel, Johan Frostegård
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/979b1be1e0cc42eba50336515cbe7837
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spelling	oai:doaj.org-article:979b1be1e0cc42eba50336515cbe78372021-12-02T17:30:34ZPotential natural immunization against atherosclerosis in hibernating bears10.1038/s41598-021-91679-12045-2322https://doaj.org/article/979b1be1e0cc42eba50336515cbe78372021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91679-1https://doaj.org/toc/2045-2322Abstract Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have anti-inflammatory and other potentially protective properties. PC but not MDA is exposed on different types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), significantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the difference was striking; 100 IQR (85.9–107.9) vs 782.3, IQR (422.8–1586.0; p < 0.001). In contrast, subclasses and isotypes of anti-MDA were significantly lower in winter except IgA anti-MDA, which was not detectable. Anti-PCs are significantly raised during hibernation in brown bears; especially IgA anti-PC was strikingly high. In contrast, anti-MDA titers was decreased during hibernation. Our observation may represent natural immunization with microorganisms during a vulnerable period and could have therapeutic implications for prevention of atherosclerosis.Shailesh Kumar SamalOle FröbertJonas KindbergPeter StenvinkelJohan FrostegårdNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shailesh Kumar Samal Ole Fröbert Jonas Kindberg Peter Stenvinkel Johan Frostegård Potential natural immunization against atherosclerosis in hibernating bears
description	Abstract Brown bears (Ursus arctos) hibernate for 5–6 months during winter, but despite kidney insufficiency, dyslipidemia and inactivity they do not seem to develop atherosclerosis or cardiovascular disease (CVD). IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are associated with less atherosclerosis, CVD and mortality in uremia in humans and have anti-inflammatory and other potentially protective properties. PC but not MDA is exposed on different types of microorganisms. We determine anti-PC and anti-MDA in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by enzyme linked immunosorbent assay (ELISA). When determined as arbitrary units (median set at 100 for summer samples), significantly raised levels were observed in winter for anti-PC subclasses and isotypes, and for IgA anti-PC the difference was striking; 100 IQR (85.9–107.9) vs 782.3, IQR (422.8–1586.0; p < 0.001). In contrast, subclasses and isotypes of anti-MDA were significantly lower in winter except IgA anti-MDA, which was not detectable. Anti-PCs are significantly raised during hibernation in brown bears; especially IgA anti-PC was strikingly high. In contrast, anti-MDA titers was decreased during hibernation. Our observation may represent natural immunization with microorganisms during a vulnerable period and could have therapeutic implications for prevention of atherosclerosis.
format	article
author	Shailesh Kumar Samal Ole Fröbert Jonas Kindberg Peter Stenvinkel Johan Frostegård
author_facet	Shailesh Kumar Samal Ole Fröbert Jonas Kindberg Peter Stenvinkel Johan Frostegård
author_sort	Shailesh Kumar Samal
title	Potential natural immunization against atherosclerosis in hibernating bears
title_short	Potential natural immunization against atherosclerosis in hibernating bears
title_full	Potential natural immunization against atherosclerosis in hibernating bears
title_fullStr	Potential natural immunization against atherosclerosis in hibernating bears
title_full_unstemmed	Potential natural immunization against atherosclerosis in hibernating bears
title_sort	potential natural immunization against atherosclerosis in hibernating bears
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/979b1be1e0cc42eba50336515cbe7837
work_keys_str_mv	AT shaileshkumarsamal potentialnaturalimmunizationagainstatherosclerosisinhibernatingbears AT olefrobert potentialnaturalimmunizationagainstatherosclerosisinhibernatingbears AT jonaskindberg potentialnaturalimmunizationagainstatherosclerosisinhibernatingbears AT peterstenvinkel potentialnaturalimmunizationagainstatherosclerosisinhibernatingbears AT johanfrostegard potentialnaturalimmunizationagainstatherosclerosisinhibernatingbears
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Potential natural immunization against atherosclerosis in hibernating bears

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