Maternal immune activation induces sustained changes in fetal microglia motility

Abstract Maternal infection or inflammation causes abnormalities in brain development associated with subsequent cognitive impairment and in an increased susceptibility to schizophrenia and autism spectrum disorders. Maternal immune activation (MIA) and increases in serum cytokine levels mediates th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kana Ozaki, Daisuke Kato, Ako Ikegami, Akari Hashimoto, Shouta Sugio, Zhongtian Guo, Midori Shibushita, Tsuyako Tatematsu, Koichiro Haruwaka, Andrew J. Moorhouse, Hideto Yamada, Hiroaki Wake
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/979f3c83c7a34bd2aeab127d90ed220a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:979f3c83c7a34bd2aeab127d90ed220a
record_format	dspace
spelling	oai:doaj.org-article:979f3c83c7a34bd2aeab127d90ed220a2021-12-02T12:33:45ZMaternal immune activation induces sustained changes in fetal microglia motility10.1038/s41598-020-78294-22045-2322https://doaj.org/article/979f3c83c7a34bd2aeab127d90ed220a2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78294-2https://doaj.org/toc/2045-2322Abstract Maternal infection or inflammation causes abnormalities in brain development associated with subsequent cognitive impairment and in an increased susceptibility to schizophrenia and autism spectrum disorders. Maternal immune activation (MIA) and increases in serum cytokine levels mediates this association via effects on the fetal brain, and microglia can respond to maternal immune status, but consensus on how microglia may respond is lacking and no-one has yet examined if microglial process motility is impaired. In this study we investigated how MIA induced at two different gestational ages affected microglial properties at different developmental stages. Immune activation in mid-pregnancy increased IL-6 expression in embryonic microglia, but failed to cause any marked changes in morphology either at E18 or postnatally. In contrast MIA, particularly when induced earlier (at E12), caused sustained alterations in the patterns of microglial process motility and behavioral deficits. Our research has identified an important microglial property that is altered by MIA and which may contribute to the underlying pathophysiological mechanisms linking maternal immune status to subsequent risks for cognitive disease.Kana OzakiDaisuke KatoAko IkegamiAkari HashimotoShouta SugioZhongtian GuoMidori ShibushitaTsuyako TatematsuKoichiro HaruwakaAndrew J. MoorhouseHideto YamadaHiroaki WakeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kana Ozaki Daisuke Kato Ako Ikegami Akari Hashimoto Shouta Sugio Zhongtian Guo Midori Shibushita Tsuyako Tatematsu Koichiro Haruwaka Andrew J. Moorhouse Hideto Yamada Hiroaki Wake Maternal immune activation induces sustained changes in fetal microglia motility
description	Abstract Maternal infection or inflammation causes abnormalities in brain development associated with subsequent cognitive impairment and in an increased susceptibility to schizophrenia and autism spectrum disorders. Maternal immune activation (MIA) and increases in serum cytokine levels mediates this association via effects on the fetal brain, and microglia can respond to maternal immune status, but consensus on how microglia may respond is lacking and no-one has yet examined if microglial process motility is impaired. In this study we investigated how MIA induced at two different gestational ages affected microglial properties at different developmental stages. Immune activation in mid-pregnancy increased IL-6 expression in embryonic microglia, but failed to cause any marked changes in morphology either at E18 or postnatally. In contrast MIA, particularly when induced earlier (at E12), caused sustained alterations in the patterns of microglial process motility and behavioral deficits. Our research has identified an important microglial property that is altered by MIA and which may contribute to the underlying pathophysiological mechanisms linking maternal immune status to subsequent risks for cognitive disease.
format	article
author	Kana Ozaki Daisuke Kato Ako Ikegami Akari Hashimoto Shouta Sugio Zhongtian Guo Midori Shibushita Tsuyako Tatematsu Koichiro Haruwaka Andrew J. Moorhouse Hideto Yamada Hiroaki Wake
author_facet	Kana Ozaki Daisuke Kato Ako Ikegami Akari Hashimoto Shouta Sugio Zhongtian Guo Midori Shibushita Tsuyako Tatematsu Koichiro Haruwaka Andrew J. Moorhouse Hideto Yamada Hiroaki Wake
author_sort	Kana Ozaki
title	Maternal immune activation induces sustained changes in fetal microglia motility
title_short	Maternal immune activation induces sustained changes in fetal microglia motility
title_full	Maternal immune activation induces sustained changes in fetal microglia motility
title_fullStr	Maternal immune activation induces sustained changes in fetal microglia motility
title_full_unstemmed	Maternal immune activation induces sustained changes in fetal microglia motility
title_sort	maternal immune activation induces sustained changes in fetal microglia motility
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/979f3c83c7a34bd2aeab127d90ed220a
work_keys_str_mv	AT kanaozaki maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility AT daisukekato maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility AT akoikegami maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility AT akarihashimoto maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility AT shoutasugio maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility AT zhongtianguo maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility AT midorishibushita maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility AT tsuyakotatematsu maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility AT koichiroharuwaka maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility AT andrewjmoorhouse maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility AT hidetoyamada maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility AT hiroakiwake maternalimmuneactivationinducessustainedchangesinfetalmicrogliamotility
_version_	1718393874431344640

Maternal immune activation induces sustained changes in fetal microglia motility

Ejemplares similares