Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

The L protein of segmented, negative strand RNA viruses contains the RNA-dependent RNA polymerase essential for virus amplification. Here, the authors report cryoEM structures of the Lassa virus L protein in active, RNA-bound states, and provide mechanistic insights.

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Autores principales:	Tomas Kouba, Dominik Vogel, Sigurdur R. Thorkelsson, Emmanuelle R. J. Quemin, Harry M. Williams, Morlin Milewski, Carola Busch, Stephan Günther, Kay Grünewald, Maria Rosenthal, Stephen Cusack
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/97a04e7215a44a4ebaec52c71bff412e
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spelling	oai:doaj.org-article:97a04e7215a44a4ebaec52c71bff412e2021-12-05T12:22:47ZConformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity10.1038/s41467-021-27305-52041-1723https://doaj.org/article/97a04e7215a44a4ebaec52c71bff412e2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27305-5https://doaj.org/toc/2041-1723The L protein of segmented, negative strand RNA viruses contains the RNA-dependent RNA polymerase essential for virus amplification. Here, the authors report cryoEM structures of the Lassa virus L protein in active, RNA-bound states, and provide mechanistic insights.Tomas KoubaDominik VogelSigurdur R. ThorkelssonEmmanuelle R. J. QueminHarry M. WilliamsMorlin MilewskiCarola BuschStephan GüntherKay GrünewaldMaria RosenthalStephen CusackNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomas Kouba Dominik Vogel Sigurdur R. Thorkelsson Emmanuelle R. J. Quemin Harry M. Williams Morlin Milewski Carola Busch Stephan Günther Kay Grünewald Maria Rosenthal Stephen Cusack Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity
description	The L protein of segmented, negative strand RNA viruses contains the RNA-dependent RNA polymerase essential for virus amplification. Here, the authors report cryoEM structures of the Lassa virus L protein in active, RNA-bound states, and provide mechanistic insights.
format	article
author	Tomas Kouba Dominik Vogel Sigurdur R. Thorkelsson Emmanuelle R. J. Quemin Harry M. Williams Morlin Milewski Carola Busch Stephan Günther Kay Grünewald Maria Rosenthal Stephen Cusack
author_facet	Tomas Kouba Dominik Vogel Sigurdur R. Thorkelsson Emmanuelle R. J. Quemin Harry M. Williams Morlin Milewski Carola Busch Stephan Günther Kay Grünewald Maria Rosenthal Stephen Cusack
author_sort	Tomas Kouba
title	Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity
title_short	Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity
title_full	Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity
title_fullStr	Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity
title_full_unstemmed	Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity
title_sort	conformational changes in lassa virus l protein associated with promoter binding and rna synthesis activity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97a04e7215a44a4ebaec52c71bff412e
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Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

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