Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

The L protein of segmented, negative strand RNA viruses contains the RNA-dependent RNA polymerase essential for virus amplification. Here, the authors report cryoEM structures of the Lassa virus L protein in active, RNA-bound states, and provide mechanistic insights.

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Autores principales: Tomas Kouba, Dominik Vogel, Sigurdur R. Thorkelsson, Emmanuelle R. J. Quemin, Harry M. Williams, Morlin Milewski, Carola Busch, Stephan Günther, Kay Grünewald, Maria Rosenthal, Stephen Cusack
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/97a04e7215a44a4ebaec52c71bff412e
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