Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic

Breast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing the impact of such treatment on the vasculature despite its ce...

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Autores principales:	Marie Mclaughlin, Geraint Florida-James, Mark Ross
Formato:	article
Lenguaje:	EN
Publicado:	Bioscientifica 2021
Materias:	chemotherapy cardiovascular toxicity vasculo-oncology endothelium exercise cardio-oncology Diseases of the circulatory (Cardiovascular) system RC666-701 Physiology QP1-981
Acceso en línea:	https://doi.org/10.1530/VB-21-0013 https://doaj.org/article/97a1e5cf09584e95a643d32dea50f647
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spelling	oai:doaj.org-article:97a1e5cf09584e95a643d32dea50f6472021-11-16T06:44:50ZBreast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutichttps://doi.org/10.1530/VB-21-00132516-5658https://doaj.org/article/97a1e5cf09584e95a643d32dea50f6472021-11-01T00:00:00Zhttps://vb.bioscientifica.com/view/journals/vb/3/1/VB-21-0013.xmlhttps://doaj.org/toc/2516-5658Breast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing the impact of such treatment on the vasculature despite its central importance within the cardiovascular system and resultant detrimental effects of damage and dysfunction. This review highlights the impact of chemotherapy for breast cancer on the vascular endothelium. We consider the most likely mechanisms of endothelial toxicity to be through direct damage and dysfunction of the endothelium. There are sharp consequences of these detrimental effects as they can lead to cardiovascular disease. However, there is potential for exercise to alleviate some of the vascular toxicity of chemotherapy, and the evidence for this is provided. The potential role of exercise in protecting against vascular toxicity is explained, highlighting the recent in-human and animal model exercise interventions. Lastly, the mediating mechanisms of exercise protection of endothelial health is discussed, focusing on the importance of exercise for endothelial health, function, repair, inflammation and hyperlipidaemia, angiogenesis, and vascular remodelling. These are all important counteracting measures against chemotherapy-induced toxicity and are discussed in detail.Marie MclaughlinGeraint Florida-JamesMark RossBioscientificaarticlechemotherapycardiovascular toxicityvasculo-oncologyendotheliumexercisecardio-oncologyDiseases of the circulatory (Cardiovascular) systemRC666-701PhysiologyQP1-981ENVascular Biology, Vol 3, Iss 1, Pp R106-R120 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemotherapy cardiovascular toxicity vasculo-oncology endothelium exercise cardio-oncology Diseases of the circulatory (Cardiovascular) system RC666-701 Physiology QP1-981
spellingShingle	chemotherapy cardiovascular toxicity vasculo-oncology endothelium exercise cardio-oncology Diseases of the circulatory (Cardiovascular) system RC666-701 Physiology QP1-981 Marie Mclaughlin Geraint Florida-James Mark Ross Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic
description	Breast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing the impact of such treatment on the vasculature despite its central importance within the cardiovascular system and resultant detrimental effects of damage and dysfunction. This review highlights the impact of chemotherapy for breast cancer on the vascular endothelium. We consider the most likely mechanisms of endothelial toxicity to be through direct damage and dysfunction of the endothelium. There are sharp consequences of these detrimental effects as they can lead to cardiovascular disease. However, there is potential for exercise to alleviate some of the vascular toxicity of chemotherapy, and the evidence for this is provided. The potential role of exercise in protecting against vascular toxicity is explained, highlighting the recent in-human and animal model exercise interventions. Lastly, the mediating mechanisms of exercise protection of endothelial health is discussed, focusing on the importance of exercise for endothelial health, function, repair, inflammation and hyperlipidaemia, angiogenesis, and vascular remodelling. These are all important counteracting measures against chemotherapy-induced toxicity and are discussed in detail.
format	article
author	Marie Mclaughlin Geraint Florida-James Mark Ross
author_facet	Marie Mclaughlin Geraint Florida-James Mark Ross
author_sort	Marie Mclaughlin
title	Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic
title_short	Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic
title_full	Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic
title_fullStr	Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic
title_full_unstemmed	Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic
title_sort	breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic
publisher	Bioscientifica
publishDate	2021
url	https://doi.org/10.1530/VB-21-0013 https://doaj.org/article/97a1e5cf09584e95a643d32dea50f647
work_keys_str_mv	AT mariemclaughlin breastcancerchemotherapyvasculartoxicityareviewofmediatingmechanismsandexerciseasapotentialtherapeutic AT geraintfloridajames breastcancerchemotherapyvasculartoxicityareviewofmediatingmechanismsandexerciseasapotentialtherapeutic AT markross breastcancerchemotherapyvasculartoxicityareviewofmediatingmechanismsandexerciseasapotentialtherapeutic
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Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic

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