In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate

Introduction Little is known about pathogenetic mechanisms of superficial venous thrombosis (SVT). We aimed to investigate the systemic inflammatory response in the acute phase of SVT, the time course of inflammatory markers and involvement of inflammation in resolution of thrombus in SVT. Material...

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Autores principales:	Pavel Poredoš, Ana Spirkoska, Mateja Kaja Ježovnik
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	inflammation inflammatory markers anticoagulants superficial venous thrombosis thrombophlebitis Medicine R
Acceso en línea:	https://doaj.org/article/97a2e3a239ce45f78a8b5974143b8c81
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spelling	oai:doaj.org-article:97a2e3a239ce45f78a8b5974143b8c812021-12-02T18:33:05ZIn patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate1734-19221896-915110.5114/aoms.2019.83292https://doaj.org/article/97a2e3a239ce45f78a8b5974143b8c812019-03-01T00:00:00Zhttps://www.archivesofmedicalscience.com/In-patients-with-superficial-vein-thrombosis-the-inflammatory-response-is-increased,69542,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Little is known about pathogenetic mechanisms of superficial venous thrombosis (SVT). We aimed to investigate the systemic inflammatory response in the acute phase of SVT, the time course of inflammatory markers and involvement of inflammation in resolution of thrombus in SVT. Material and methods The circulatory inflammatory parameters high-sensitivity C-reactive protein (hsCRP), tumor necrosis factor α (TNF-α), interleukins 6, 8 and 10 (IL-6, IL-8, IL-10), and markers of fibrinolytic activity tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and fibrinogen were determined in 68 patients with acute SVT of lower limbs, who were allocated to two groups, dalteparin 5000 IU once daily or 10 000 IU once daily. Recanalization of occluded veins was monitored by ultrasonography at regular intervals. Blood was drawn in the acute phase and after 12 weeks. Results In the acute phase a majority of the measured inflammatory markers were increased, while after 12 weeks most of them significantly dropped: hsCRP: 13.6 ±11.9 vs. 7.4 ±4.4, p < 0.001; IL-6: 3.8 ±3.1 vs. 2.6 ±1.9, p = 0.007. Significant changes in endogenic fibrinolytic parameters were also observed: t-PA activity decreased (0.81 ±0.35 vs. 0.68 ±0.34, p = 0.003), while PAI-1 levels increased (5.6 ±5.1 vs. 8.8 ±8.5, p < 0.001). Levels of inflammatory markers at inclusion and after 12 weeks were related to less effective thrombus resolution: CRP: r = 0.386, p = 0.001; IL-6: r = 0.384; TNF-α: r = 0.255, p = 0.037. Conclusions In the acute phase of SVT, most of the circulating inflammatory markers were increased and most of their levels decreased after 12 weeks. Levels of inflammatory markers were negatively correlated with the recanalization rate.Pavel PoredošAna SpirkoskaMateja Kaja JežovnikTermedia Publishing Housearticleinflammationinflammatory markersanticoagulantssuperficial venous thrombosisthrombophlebitisinflammatory markersMedicineRENArchives of Medical Science, Vol 15, Iss 2, Pp 393-401 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammation inflammatory markers anticoagulants superficial venous thrombosis thrombophlebitis inflammatory markers Medicine R
spellingShingle	inflammation inflammatory markers anticoagulants superficial venous thrombosis thrombophlebitis inflammatory markers Medicine R Pavel Poredoš Ana Spirkoska Mateja Kaja Ježovnik In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate
description	Introduction Little is known about pathogenetic mechanisms of superficial venous thrombosis (SVT). We aimed to investigate the systemic inflammatory response in the acute phase of SVT, the time course of inflammatory markers and involvement of inflammation in resolution of thrombus in SVT. Material and methods The circulatory inflammatory parameters high-sensitivity C-reactive protein (hsCRP), tumor necrosis factor α (TNF-α), interleukins 6, 8 and 10 (IL-6, IL-8, IL-10), and markers of fibrinolytic activity tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and fibrinogen were determined in 68 patients with acute SVT of lower limbs, who were allocated to two groups, dalteparin 5000 IU once daily or 10 000 IU once daily. Recanalization of occluded veins was monitored by ultrasonography at regular intervals. Blood was drawn in the acute phase and after 12 weeks. Results In the acute phase a majority of the measured inflammatory markers were increased, while after 12 weeks most of them significantly dropped: hsCRP: 13.6 ±11.9 vs. 7.4 ±4.4, p < 0.001; IL-6: 3.8 ±3.1 vs. 2.6 ±1.9, p = 0.007. Significant changes in endogenic fibrinolytic parameters were also observed: t-PA activity decreased (0.81 ±0.35 vs. 0.68 ±0.34, p = 0.003), while PAI-1 levels increased (5.6 ±5.1 vs. 8.8 ±8.5, p < 0.001). Levels of inflammatory markers at inclusion and after 12 weeks were related to less effective thrombus resolution: CRP: r = 0.386, p = 0.001; IL-6: r = 0.384; TNF-α: r = 0.255, p = 0.037. Conclusions In the acute phase of SVT, most of the circulating inflammatory markers were increased and most of their levels decreased after 12 weeks. Levels of inflammatory markers were negatively correlated with the recanalization rate.
format	article
author	Pavel Poredoš Ana Spirkoska Mateja Kaja Ježovnik
author_facet	Pavel Poredoš Ana Spirkoska Mateja Kaja Ježovnik
author_sort	Pavel Poredoš
title	In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate
title_short	In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate
title_full	In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate
title_fullStr	In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate
title_full_unstemmed	In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate
title_sort	in patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/97a2e3a239ce45f78a8b5974143b8c81
work_keys_str_mv	AT pavelporedos inpatientswithsuperficialveinthrombosistheinflammatoryresponseisincreasedandrelatedtotherecanalizationrate AT anaspirkoska inpatientswithsuperficialveinthrombosistheinflammatoryresponseisincreasedandrelatedtotherecanalizationrate AT matejakajajezovnik inpatientswithsuperficialveinthrombosistheinflammatoryresponseisincreasedandrelatedtotherecanalizationrate
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In patients with superficial vein thrombosis the inflammatory response is increased and related to the recanalization rate

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