Modulation of human time processing by subthalamic deep brain stimulation.

Timing in the range of seconds referred to as interval timing is crucial for cognitive operations and conscious time processing. According to recent models of interval timing basal ganglia (BG) oscillatory loops are involved in time interval recognition. Parkinsońs disease (PD) is a typical disease...

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Autores principales:	Lars Wojtecki, Saskia Elben, Lars Timmermann, Christiane Reck, Mohammad Maarouf, Silke Jörgens, Markus Ploner, Martin Südmeyer, Stefan Jun Groiss, Volker Sturm, Michael Niedeggen, Alfons Schnitzler
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97a3355bc1224b39b4309318bf98a6b0
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spelling	oai:doaj.org-article:97a3355bc1224b39b4309318bf98a6b02021-11-04T06:08:49ZModulation of human time processing by subthalamic deep brain stimulation.1932-620310.1371/journal.pone.0024589https://doaj.org/article/97a3355bc1224b39b4309318bf98a6b02011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931767/?tool=EBIhttps://doaj.org/toc/1932-6203Timing in the range of seconds referred to as interval timing is crucial for cognitive operations and conscious time processing. According to recent models of interval timing basal ganglia (BG) oscillatory loops are involved in time interval recognition. Parkinsońs disease (PD) is a typical disease of the basal ganglia that shows distortions in interval timing. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a powerful treatment of PD which modulates motor and cognitive functions depending on stimulation frequency by affecting subcortical-cortical oscillatory loops. Thus, for the understanding of BG-involvement in interval timing it is of interest whether STN-DBS can modulate timing in a frequency dependent manner by interference with oscillatory time recognition processes. We examined production and reproduction of 5 and 15 second intervals and millisecond timing in a double blind, randomised, within-subject repeated-measures design of 12 PD-patients applying no, 10-Hz- and ≥ 130-Hz-STN-DBS compared to healthy controls. We found under(re-)production of the 15-second interval and a significant enhancement of this under(re-)production by 10-Hz-stimulation compared to no stimulation, ≥ 130-Hz-STN-DBS and controls. Milliseconds timing was not affected. We provide first evidence for a frequency-specific modulatory effect of STN-DBS on interval timing. Our results corroborate the involvement of BG in general and of the STN in particular in the cognitive representation of time intervals in the range of multiple seconds.Lars WojteckiSaskia ElbenLars TimmermannChristiane ReckMohammad MaaroufSilke JörgensMarkus PlonerMartin SüdmeyerStefan Jun GroissVolker SturmMichael NiedeggenAlfons SchnitzlerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24589 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lars Wojtecki Saskia Elben Lars Timmermann Christiane Reck Mohammad Maarouf Silke Jörgens Markus Ploner Martin Südmeyer Stefan Jun Groiss Volker Sturm Michael Niedeggen Alfons Schnitzler Modulation of human time processing by subthalamic deep brain stimulation.
description	Timing in the range of seconds referred to as interval timing is crucial for cognitive operations and conscious time processing. According to recent models of interval timing basal ganglia (BG) oscillatory loops are involved in time interval recognition. Parkinsońs disease (PD) is a typical disease of the basal ganglia that shows distortions in interval timing. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a powerful treatment of PD which modulates motor and cognitive functions depending on stimulation frequency by affecting subcortical-cortical oscillatory loops. Thus, for the understanding of BG-involvement in interval timing it is of interest whether STN-DBS can modulate timing in a frequency dependent manner by interference with oscillatory time recognition processes. We examined production and reproduction of 5 and 15 second intervals and millisecond timing in a double blind, randomised, within-subject repeated-measures design of 12 PD-patients applying no, 10-Hz- and ≥ 130-Hz-STN-DBS compared to healthy controls. We found under(re-)production of the 15-second interval and a significant enhancement of this under(re-)production by 10-Hz-stimulation compared to no stimulation, ≥ 130-Hz-STN-DBS and controls. Milliseconds timing was not affected. We provide first evidence for a frequency-specific modulatory effect of STN-DBS on interval timing. Our results corroborate the involvement of BG in general and of the STN in particular in the cognitive representation of time intervals in the range of multiple seconds.
format	article
author	Lars Wojtecki Saskia Elben Lars Timmermann Christiane Reck Mohammad Maarouf Silke Jörgens Markus Ploner Martin Südmeyer Stefan Jun Groiss Volker Sturm Michael Niedeggen Alfons Schnitzler
author_facet	Lars Wojtecki Saskia Elben Lars Timmermann Christiane Reck Mohammad Maarouf Silke Jörgens Markus Ploner Martin Südmeyer Stefan Jun Groiss Volker Sturm Michael Niedeggen Alfons Schnitzler
author_sort	Lars Wojtecki
title	Modulation of human time processing by subthalamic deep brain stimulation.
title_short	Modulation of human time processing by subthalamic deep brain stimulation.
title_full	Modulation of human time processing by subthalamic deep brain stimulation.
title_fullStr	Modulation of human time processing by subthalamic deep brain stimulation.
title_full_unstemmed	Modulation of human time processing by subthalamic deep brain stimulation.
title_sort	modulation of human time processing by subthalamic deep brain stimulation.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/97a3355bc1224b39b4309318bf98a6b0
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_version_	1718445164170575872

Modulation of human time processing by subthalamic deep brain stimulation.

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