Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model

Abstract Despite the high potential of healthy bone to regenerate, the reconstruction of large bone defects remains a challenge. Due to the lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load-be...

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Autores principales:	Bernd Wegener, Maik Behnke, Stefan Milz, Volkmar Jansson, Christian Redlich, Walter Hermanns, Christof Birkenmaier, Korbinian Pieper, Thomas Weißgärber, Peter Quadbeck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/97a636c8367a459399688b0fe5b0a172
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spelling	oai:doaj.org-article:97a636c8367a459399688b0fe5b0a1722021-12-02T17:30:40ZLocal and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model10.1038/s41598-021-91296-y2045-2322https://doaj.org/article/97a636c8367a459399688b0fe5b0a1722021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91296-yhttps://doaj.org/toc/2045-2322Abstract Despite the high potential of healthy bone to regenerate, the reconstruction of large bone defects remains a challenge. Due to the lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load-bearing capabilities. Degradable iron-based alloys therefore might be an attractive innovation. To test the suitability of a newly-designed iron-based alloy for such applications, an animal experiment was performed. Porous iron-based degradable implants with two different densities and a control group were tested. The implants were positioned in the proximal tibia of Merino sheep. Over a period of 6 and 12 months, blood and histological parameters were monitored for signs of inflammation and degradation. In the histological evaluation of the implants` environment we found degraded alloy particles, but no inflammatory reaction. Iron particles were also found within the popliteal lymph nodes on both sides. The serum blood levels of phosphorus, iron and ferritin in the long term groups were elevated. Other parameters did not show any changes. Iron-based degradable porous bone replacement implants showed a good biocompatibility in this experiment. For a clinical application, however, the rate of degradation would have to be significantly increased. Biocompatibility would then have to be re-evaluated.Bernd WegenerMaik BehnkeStefan MilzVolkmar JanssonChristian RedlichWalter HermannsChristof BirkenmaierKorbinian PieperThomas WeißgärberPeter QuadbeckNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bernd Wegener Maik Behnke Stefan Milz Volkmar Jansson Christian Redlich Walter Hermanns Christof Birkenmaier Korbinian Pieper Thomas Weißgärber Peter Quadbeck Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
description	Abstract Despite the high potential of healthy bone to regenerate, the reconstruction of large bone defects remains a challenge. Due to the lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load-bearing capabilities. Degradable iron-based alloys therefore might be an attractive innovation. To test the suitability of a newly-designed iron-based alloy for such applications, an animal experiment was performed. Porous iron-based degradable implants with two different densities and a control group were tested. The implants were positioned in the proximal tibia of Merino sheep. Over a period of 6 and 12 months, blood and histological parameters were monitored for signs of inflammation and degradation. In the histological evaluation of the implants` environment we found degraded alloy particles, but no inflammatory reaction. Iron particles were also found within the popliteal lymph nodes on both sides. The serum blood levels of phosphorus, iron and ferritin in the long term groups were elevated. Other parameters did not show any changes. Iron-based degradable porous bone replacement implants showed a good biocompatibility in this experiment. For a clinical application, however, the rate of degradation would have to be significantly increased. Biocompatibility would then have to be re-evaluated.
format	article
author	Bernd Wegener Maik Behnke Stefan Milz Volkmar Jansson Christian Redlich Walter Hermanns Christof Birkenmaier Korbinian Pieper Thomas Weißgärber Peter Quadbeck
author_facet	Bernd Wegener Maik Behnke Stefan Milz Volkmar Jansson Christian Redlich Walter Hermanns Christof Birkenmaier Korbinian Pieper Thomas Weißgärber Peter Quadbeck
author_sort	Bernd Wegener
title	Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
title_short	Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
title_full	Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
title_fullStr	Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
title_full_unstemmed	Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
title_sort	local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/97a636c8367a459399688b0fe5b0a172
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Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model

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