Cortical Hyper-Connectivity in a Stroke Patient with Rotated Drawing

In the present case report, we investigated the cortical networks of a patient (DDA) affected by right parietal stroke who showed a constructional phenomenon, in which when coping and recalling from memory a complex figure, the model was reproduced rotated of 90° along the vertical axis. Previous st...

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Autores principales:	Valentina Sebastiani, Piero Chiacchiaretta, Luigi Pavone, Antonio Sparano, Giovanni Grillea, Sara Spadone, Paolo Capotosto, Giorgia Committeri, Antonello Baldassarre
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	stroke rotated drawing functional connectivity brain networks Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/97a95d7d1eb54160aaa8921c6d0beff4
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id	oai:doaj.org-article:97a95d7d1eb54160aaa8921c6d0beff4
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spelling	oai:doaj.org-article:97a95d7d1eb54160aaa8921c6d0beff42021-11-18T11:08:45ZCortical Hyper-Connectivity in a Stroke Patient with Rotated Drawing1662-680X10.1159/000518844https://doaj.org/article/97a95d7d1eb54160aaa8921c6d0beff42021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/518844https://doaj.org/toc/1662-680XIn the present case report, we investigated the cortical networks of a patient (DDA) affected by right parietal stroke who showed a constructional phenomenon, in which when coping and recalling from memory a complex figure, the model was reproduced rotated of 90° along the vertical axis. Previous studies suggested that rotation on copy is associated with visuospatial impairments and abnormalities in parietal cortex, whereas rotation on recall might be related to executive deficits and dysfunction of frontal regions. Here, we computed the DDA’s resting-state functional connectivity (FC) derived from cortical regions of the dorsal attention (DAN) and the frontal portion of the executive-control network (fECN), which are involved in the control of visuospatial attention and multiple executive functions, respectively. We observed that, as compared to a control group of right stroke patients without drawing rotation, DDA exhibited selective increased FC of the DAN and fECN, but not of task-irrelevant language network, within the undamaged hemisphere. These patterns might reflect a pathological communication in such networks leading to impaired attentional and executive operations required to reproduce the model in the correct orientation. Notably, such enhancement of FC was not detected in a patient with a comparable neuropsychological profile as DDA, yet without rotated drawing, suggesting that network-specific modulations in DDA might be ascribed to the constructional phenomenon of rotated drawing.Valentina SebastianiPiero ChiacchiarettaLuigi PavoneAntonio SparanoGiovanni GrilleaSara SpadonePaolo CapotostoGiorgia CommitteriAntonello BaldassarreKarger Publishersarticlestrokerotated drawingfunctional connectivitybrain networksNeurology. Diseases of the nervous systemRC346-429ENCase Reports in Neurology, Vol 13, Iss 3, Pp 677-686 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke rotated drawing functional connectivity brain networks Neurology. Diseases of the nervous system RC346-429
spellingShingle	stroke rotated drawing functional connectivity brain networks Neurology. Diseases of the nervous system RC346-429 Valentina Sebastiani Piero Chiacchiaretta Luigi Pavone Antonio Sparano Giovanni Grillea Sara Spadone Paolo Capotosto Giorgia Committeri Antonello Baldassarre Cortical Hyper-Connectivity in a Stroke Patient with Rotated Drawing
description	In the present case report, we investigated the cortical networks of a patient (DDA) affected by right parietal stroke who showed a constructional phenomenon, in which when coping and recalling from memory a complex figure, the model was reproduced rotated of 90° along the vertical axis. Previous studies suggested that rotation on copy is associated with visuospatial impairments and abnormalities in parietal cortex, whereas rotation on recall might be related to executive deficits and dysfunction of frontal regions. Here, we computed the DDA’s resting-state functional connectivity (FC) derived from cortical regions of the dorsal attention (DAN) and the frontal portion of the executive-control network (fECN), which are involved in the control of visuospatial attention and multiple executive functions, respectively. We observed that, as compared to a control group of right stroke patients without drawing rotation, DDA exhibited selective increased FC of the DAN and fECN, but not of task-irrelevant language network, within the undamaged hemisphere. These patterns might reflect a pathological communication in such networks leading to impaired attentional and executive operations required to reproduce the model in the correct orientation. Notably, such enhancement of FC was not detected in a patient with a comparable neuropsychological profile as DDA, yet without rotated drawing, suggesting that network-specific modulations in DDA might be ascribed to the constructional phenomenon of rotated drawing.
format	article
author	Valentina Sebastiani Piero Chiacchiaretta Luigi Pavone Antonio Sparano Giovanni Grillea Sara Spadone Paolo Capotosto Giorgia Committeri Antonello Baldassarre
author_facet	Valentina Sebastiani Piero Chiacchiaretta Luigi Pavone Antonio Sparano Giovanni Grillea Sara Spadone Paolo Capotosto Giorgia Committeri Antonello Baldassarre
author_sort	Valentina Sebastiani
title	Cortical Hyper-Connectivity in a Stroke Patient with Rotated Drawing
title_short	Cortical Hyper-Connectivity in a Stroke Patient with Rotated Drawing
title_full	Cortical Hyper-Connectivity in a Stroke Patient with Rotated Drawing
title_fullStr	Cortical Hyper-Connectivity in a Stroke Patient with Rotated Drawing
title_full_unstemmed	Cortical Hyper-Connectivity in a Stroke Patient with Rotated Drawing
title_sort	cortical hyper-connectivity in a stroke patient with rotated drawing
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/97a95d7d1eb54160aaa8921c6d0beff4
work_keys_str_mv	AT valentinasebastiani corticalhyperconnectivityinastrokepatientwithrotateddrawing AT pierochiacchiaretta corticalhyperconnectivityinastrokepatientwithrotateddrawing AT luigipavone corticalhyperconnectivityinastrokepatientwithrotateddrawing AT antoniosparano corticalhyperconnectivityinastrokepatientwithrotateddrawing AT giovannigrillea corticalhyperconnectivityinastrokepatientwithrotateddrawing AT saraspadone corticalhyperconnectivityinastrokepatientwithrotateddrawing AT paolocapotosto corticalhyperconnectivityinastrokepatientwithrotateddrawing AT giorgiacommitteri corticalhyperconnectivityinastrokepatientwithrotateddrawing AT antonellobaldassarre corticalhyperconnectivityinastrokepatientwithrotateddrawing
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Cortical Hyper-Connectivity in a Stroke Patient with Rotated Drawing

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