DYNAMIC CHANGES OF CHEMOKINE CXCL-10 (IP-10) IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS

CXCL10 (IP-10) chemokine is one of additional humoral markers applied along with determination of antigen-induced IFNγ for diagnosis of latent tuberculosis infection in humans. Dynamics of the IP-10 changes and its prognostic value in planning treatment for various forms of tuberculosis is a scarcel...

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Autores principales:	M. M. Averbakh (Jr), L. V. Panova, M. F. Gubkina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	tuberculosis children adolescents chemokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/97a97eb453384a72a9083c8b454595d9
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spelling	oai:doaj.org-article:97a97eb453384a72a9083c8b454595d92021-11-18T08:03:45ZDYNAMIC CHANGES OF CHEMOKINE CXCL-10 (IP-10) IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2016-3-279-286https://doaj.org/article/97a97eb453384a72a9083c8b454595d92016-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1041https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XCXCL10 (IP-10) chemokine is one of additional humoral markers applied along with determination of antigen-induced IFNγ for diagnosis of latent tuberculosis infection in humans. Dynamics of the IP-10 changes and its prognostic value in planning treatment for various forms of tuberculosis is a scarcely studied problem, especially, in children and adolescents. Present study has revealed an increase in spontaneous and antigen-induced IP-10 production in children and adolescents with overt tuberculosis, when compared with latent course of tuberculosis, followed by its significant reduction in cases of successful chemotherapy of tuberculosis. Such dynamics was not evident in destructive forms of tuberculosis manifesting as torpid and progressive infection.M. M. Averbakh (Jr)L. V. PanovaM. F. GubkinaSPb RAACIarticletuberculosischildrenadolescentschemokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 3, Pp 279-286 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis children adolescents chemokines Immunologic diseases. Allergy RC581-607
spellingShingle	tuberculosis children adolescents chemokines Immunologic diseases. Allergy RC581-607 M. M. Averbakh (Jr) L. V. Panova M. F. Gubkina DYNAMIC CHANGES OF CHEMOKINE CXCL-10 (IP-10) IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
description	CXCL10 (IP-10) chemokine is one of additional humoral markers applied along with determination of antigen-induced IFNγ for diagnosis of latent tuberculosis infection in humans. Dynamics of the IP-10 changes and its prognostic value in planning treatment for various forms of tuberculosis is a scarcely studied problem, especially, in children and adolescents. Present study has revealed an increase in spontaneous and antigen-induced IP-10 production in children and adolescents with overt tuberculosis, when compared with latent course of tuberculosis, followed by its significant reduction in cases of successful chemotherapy of tuberculosis. Such dynamics was not evident in destructive forms of tuberculosis manifesting as torpid and progressive infection.
format	article
author	M. M. Averbakh (Jr) L. V. Panova M. F. Gubkina
author_facet	M. M. Averbakh (Jr) L. V. Panova M. F. Gubkina
author_sort	M. M. Averbakh (Jr)
title	DYNAMIC CHANGES OF CHEMOKINE CXCL-10 (IP-10) IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
title_short	DYNAMIC CHANGES OF CHEMOKINE CXCL-10 (IP-10) IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
title_full	DYNAMIC CHANGES OF CHEMOKINE CXCL-10 (IP-10) IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
title_fullStr	DYNAMIC CHANGES OF CHEMOKINE CXCL-10 (IP-10) IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
title_full_unstemmed	DYNAMIC CHANGES OF CHEMOKINE CXCL-10 (IP-10) IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
title_sort	dynamic changes of chemokine cxcl-10 (ip-10) in children and adolescents with different forms of pulmonary tuberculosis
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/97a97eb453384a72a9083c8b454595d9
work_keys_str_mv	AT mmaverbakhjr dynamicchangesofchemokinecxcl10ip10inchildrenandadolescentswithdifferentformsofpulmonarytuberculosis AT lvpanova dynamicchangesofchemokinecxcl10ip10inchildrenandadolescentswithdifferentformsofpulmonarytuberculosis AT mfgubkina dynamicchangesofchemokinecxcl10ip10inchildrenandadolescentswithdifferentformsofpulmonarytuberculosis
_version_	1718422435476275200

DYNAMIC CHANGES OF CHEMOKINE CXCL-10 (IP-10) IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS

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