A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants

Here the authors report the isolation and structural and biological characterization of a humanized angiotensin-converting enzyme 2 (ACE2)-blocking antibody, which exterts potent inhibitory activity against SARS-CoV and circulating global SARS-CoV-2 lineages both in vitro and in hACE2 mouse model.

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Autores principales: Yanyun Du, Rui Shi, Ying Zhang, Xiaomin Duan, Li Li, Jing Zhang, Fengze Wang, Ruixue Zhang, Hao Shen, Yue Wang, Zheng Wu, Qianwen Peng, Ting Pan, Wanwei Sun, Weijin Huang, Yue Feng, Hui Feng, Junyu Xiao, Wenjie Tan, Youchun Wang, Chenhui Wang, Jinghua Yan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/97a9b5fb5db54f02ba7db4036da85f1f
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spelling oai:doaj.org-article:97a9b5fb5db54f02ba7db4036da85f1f2021-12-02T15:10:35ZA broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants10.1038/s41467-021-25331-x2041-1723https://doaj.org/article/97a9b5fb5db54f02ba7db4036da85f1f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25331-xhttps://doaj.org/toc/2041-1723Here the authors report the isolation and structural and biological characterization of a humanized angiotensin-converting enzyme 2 (ACE2)-blocking antibody, which exterts potent inhibitory activity against SARS-CoV and circulating global SARS-CoV-2 lineages both in vitro and in hACE2 mouse model.Yanyun DuRui ShiYing ZhangXiaomin DuanLi LiJing ZhangFengze WangRuixue ZhangHao ShenYue WangZheng WuQianwen PengTing PanWanwei SunWeijin HuangYue FengHui FengJunyu XiaoWenjie TanYouchun WangChenhui WangJinghua YanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yanyun Du
Rui Shi
Ying Zhang
Xiaomin Duan
Li Li
Jing Zhang
Fengze Wang
Ruixue Zhang
Hao Shen
Yue Wang
Zheng Wu
Qianwen Peng
Ting Pan
Wanwei Sun
Weijin Huang
Yue Feng
Hui Feng
Junyu Xiao
Wenjie Tan
Youchun Wang
Chenhui Wang
Jinghua Yan
A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants
description Here the authors report the isolation and structural and biological characterization of a humanized angiotensin-converting enzyme 2 (ACE2)-blocking antibody, which exterts potent inhibitory activity against SARS-CoV and circulating global SARS-CoV-2 lineages both in vitro and in hACE2 mouse model.
format article
author Yanyun Du
Rui Shi
Ying Zhang
Xiaomin Duan
Li Li
Jing Zhang
Fengze Wang
Ruixue Zhang
Hao Shen
Yue Wang
Zheng Wu
Qianwen Peng
Ting Pan
Wanwei Sun
Weijin Huang
Yue Feng
Hui Feng
Junyu Xiao
Wenjie Tan
Youchun Wang
Chenhui Wang
Jinghua Yan
author_facet Yanyun Du
Rui Shi
Ying Zhang
Xiaomin Duan
Li Li
Jing Zhang
Fengze Wang
Ruixue Zhang
Hao Shen
Yue Wang
Zheng Wu
Qianwen Peng
Ting Pan
Wanwei Sun
Weijin Huang
Yue Feng
Hui Feng
Junyu Xiao
Wenjie Tan
Youchun Wang
Chenhui Wang
Jinghua Yan
author_sort Yanyun Du
title A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants
title_short A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants
title_full A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants
title_fullStr A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants
title_full_unstemmed A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants
title_sort broadly neutralizing humanized ace2-targeting antibody against sars-cov-2 variants
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/97a9b5fb5db54f02ba7db4036da85f1f
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